Results 141 to 150 of about 53,983 (298)

RBM25 Drives Hepatocellular Carcinoma Progression by Stabilizing YAP Through Regulating Oncogenic Splicing‐switch of MYPT1

Advanced Science, EarlyView.
This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang, Lili Zhi, Tian Huang, Lingya Feng, Chaoqun Chen, Huanhuan Wei, Xiaolong Liu, Lei Chen, Jinrui Zhang, Ge Zhang, Baofeng Zhao, Rong Liu, Dan Chen, Yangfan Qi, Yang Wang   +14 more
wiley   +1 more source

Integrative Bioinformatic Approach for microRNA Interactome Networks in Human Papillomavirus-16 Infection

Eurasian Journal of Medicine
Objective: High-risk human papillomavirus (HPV), particularly HPV-16, is a major driver of carcinogenesis. Despite advances in understanding HPV-mediated oncogenesis, the role of microRNA (miRNA) interactome networks in HPV-16-driven tumorigenesis ...
Berkcan Doğan
doaj   +1 more source

Interactome INSIDER: a multi-scale structural interactome browser for genomic studies

, 2017
Protein interactions underlie nearly all known cellular function, making knowledge of their binding conformations paramount to understanding the physical workings of the cell.
Robert Fragoza, Jin Liang, Haiyuan Yu, Juan Felipe Beltrán, Aaron Rumack, Michael J. Meyer, Siqi Liang, Xiaomu Wei   +7 more
core   +1 more source

The layered interactome.

, 2014
An initial interactome was assembled using Cytoscape by merging the FunCoup (functional coupling between proteins) database with proteins encoded by the differentially expressed genes between the recurrent and monophasic T cell lines.
Yu Zhao (104852), Yucui Dong (614004), Jinfeng Yang (286633), Jianhua Sun (187443), Huan Ren (501923), Dejing Shi (614003), Huanyu Ju (614005), Xiuzhi Jia (614002), Jingbo Li (124294), Xia Li (14984)   +9 more
core   +1 more source

Exploring the potential relevance of microRNAs targeting the ARVC-related gene interaction network to cancer: an in silico testing hypothesis

Journal of Biological Research - Thessaloniki
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a genetic disorder of the myocardium. Mutations in the PKP2, DSP, DSG2, DSC2, JUP, TMEM43, PLN and DES genes which encode proteins of the cardiac desmosome have been linked to the disease yet, the
Athanasios Balaskas, Argyris Dallis, Sotirios G Zarogiannis, Chrissi Hatzoglou, Konstantinos I Gourgoulianis, Erasmia Rouka   +5 more
doaj   +1 more source

Interactome network analysis (protein-protein).

, 2015
Interactome analysis of candidate proteins with current standard HCC biomarker AFP was retrieved by tools: GeneMANIA (A & B), STRING (C & D). Interacting partners of AFP (TP53, FOXA1, FOXA3, GPC3, IGFBP1, NR3C1, F2, AHSG, ACTL6A and JUN) along with DKK1 ...
Anam Naz (800890), Hussnain Ahmed Janjua (800893), Ayesha Obaid (800891), Jamil Ahmad (327791), Amjad Ali (51075), Faryal Mehwish Awan (800889), Sadia Anjum (800892)   +6 more
core   +1 more source

Corrigendum: Adenoviromics: Mining the Human Adenovirus Species D Genome

Frontiers in Microbiology, 2018
Ashrafali M. Ismail, Ji Sun Lee, Jeong Yoon Lee, Jeong Yoon Lee, Gurdeep Singh, David W. Dyer, Donald Seto, James Chodosh, Jaya Rajaiya   +8 more
doaj   +1 more source

Proteomic Perspectives on KRAS-Driven Cancers and Emerging Therapeutic Approaches

Current Oncology
KRAS mutations are implicated in approximately 23% of all human malignancies, with particularly high prevalence in pancreatic ductal adenocarcinoma (PDAC) (~92%), colorectal cancer (CRC) (~49%), and non-small cell lung cancer (NSCLC) (~35%).
Ramesh Karki, Ru Chen, Sheng Pan
doaj   +1 more source

Interactome of Obesity: Obesidome

, 2017
Obesity is a chronic disease of increasing prevalence reaching epidemic proportions. Genetic defects as well as epigenetic effects contribute to the obesity phenotype. Investigating gene (e.g.
George Chrousos, Styliani A. Geronikolou, Cokkinos, Dennis, PAVLOPOULOU, ATHANASIA, Athanasia Pavlopoulou, Chrousos, George, Dennis Cokkinos, Geronikolou, Styliani A.   +7 more
core   +1 more source

interactomics

Citation: 'interactomics' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.09872 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source