Results 131 to 140 of about 19,346 (166)
FEBS Open BioProtein ubiquitination extensively modulates protein functions and controls various biological processes, such as protein degradation, signal transduction, transcription, and DNA repair. Ubiquitination is a reversible post‐translational modification, and
Kazuma Yoshioka +8 more
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Interactome of stargazin: relevance in neuropsychiatric disorders
, 2016 RODRIGUES. Marina Manuela Ventura - Interactome of stargazin: relevance in neuropsychiatric disorders. Coimbra : [s.n.], 2016.
Rodrigues, Marina Manuela Ventura
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Structural coverage of the human interactome
Complex biological processes in cells are embedded in the interactome, representing the complete set of protein–protein interactions. Mapping and analyzing the protein structures are essential to fully comprehending these processes’ molecular details ...
Tuncbag, Nurcan +4 more
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A TRPV2 interactome-based signature for prognosis in glioblastoma patients
Proteomics aids to the discovery and expansion of protein-protein interaction networks, which are key to understand molecular mechanisms in physiology and physiopathology, but also to infer protein function in a guilt-by-association fashion.
Peralvarez-Marin, Alex +3 more
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Acta Physiologica, 2006
AbstractThe many different functional phenotypes described in mammalian cells can only be explained by an intense interaction of the underlying proteins, substantiated by the fact that the number of independently expressed proteins in living cells seems not to exceed 25 K, a number way too small to explain the >250 K different phenotypes on a one ...
J. Fürst +14 more
openaire +3 more sources
AbstractThe many different functional phenotypes described in mammalian cells can only be explained by an intense interaction of the underlying proteins, substantiated by the fact that the number of independently expressed proteins in living cells seems not to exceed 25 K, a number way too small to explain the >250 K different phenotypes on a one ...
J. Fürst +14 more
openaire +3 more sources
Studies of the cardiolipin interactome
Progress in Lipid Research, 2022Cardiolipin (CL) is a unique phospholipid that is fundamental to the structure and function of the highly curved cristae membranes of mitochondria. Given its distinctive cone-shaped molecular architecture, CL induces negative membrane curvature in a bilayer setting.
Colin A, Fox, Robert O, Ryan
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Apoptosis, 2013
DAP-kinase (DAPK) is a Ca(2+)/calmodulin regulated Ser/Thr kinase that activates a diverse range of cellular activities. It is subject to multiple layers of regulation involving both intramolecular signaling, and interactions with additional proteins, including other kinases and phosphatases.
Shani, Bialik, Adi, Kimchi
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DAP-kinase (DAPK) is a Ca(2+)/calmodulin regulated Ser/Thr kinase that activates a diverse range of cellular activities. It is subject to multiple layers of regulation involving both intramolecular signaling, and interactions with additional proteins, including other kinases and phosphatases.
Shani, Bialik, Adi, Kimchi
openaire +2 more sources
Biochemical Journal, 2012
The cohesin complex holds the sister chromatids together from S-phase until the metaphase-to-anaphase transition, and ensures both their proper cohesion and timely separation. In addition to its canonical function in chromosomal segregation, cohesin has been suggested by several lines of investigation in recent years to play additional roles in ...
Anil K, Panigrahi +3 more
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The cohesin complex holds the sister chromatids together from S-phase until the metaphase-to-anaphase transition, and ensures both their proper cohesion and timely separation. In addition to its canonical function in chromosomal segregation, cohesin has been suggested by several lines of investigation in recent years to play additional roles in ...
Anil K, Panigrahi +3 more
openaire +2 more sources
The LC3 interactome at a glance
Journal of Cell Science, 2014Continuous synthesis of all cellular components requires their constant turnover in order for a cell to achieve homeostasis. To this end, eukaryotic cells are endowed with two degradation pathways – the ubiquitin-proteasome system and the lysosomal pathway.
P. Wild, D. G. McEwan, I. Dikic
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Annual Review of Plant Biology, 2013
Protein-protein interactions are a critical element of biological systems, and the analysis of interaction partners can provide valuable hints about unknown functions of a protein. In recent years, several large-scale protein interaction studies have begun to unravel the complex networks through which plant proteins exert their functions.
Braun, Pascal +4 more
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Protein-protein interactions are a critical element of biological systems, and the analysis of interaction partners can provide valuable hints about unknown functions of a protein. In recent years, several large-scale protein interaction studies have begun to unravel the complex networks through which plant proteins exert their functions.
Braun, Pascal +4 more
openaire +4 more sources