Results 111 to 120 of about 63,382 (353)
International Journal of Plant BiologyAquaporins are transmembrane proteins that mediate the transport of water, as well as various ions and molecules. In plants, they play a critical role in numerous processes, including stress adaptation, nutrition, cellular communication, and ...
Alvaro Lopez-Zaplana
doaj +1 more source
Advanced Science, EarlyView.This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang +12 more
wiley +1 more source
Network Medicine in the Age of Biomedical Big Data
Frontiers in Genetics, 2019 Network medicine is an emerging area of research dealing with molecular and genetic interactions, network biomarkers of disease, and therapeutic target discovery. Large-scale biomedical data generation offers a unique opportunity to assess the effect and
Abhijeet R. Sonawane +8 more
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Frontiers in Cell and Developmental Biology, 2020 Mutations in PARK2 gene are the most frequent cause of familial forms of Parkinson’s disease (PD). This gene encodes Parkin, an E3 ubiquitin ligase involved in several cellular mechanisms, including mitophagy.
Mara Zilocchi +12 more
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Interactome and transcriptome data.
, 2021 Data sheet 1: Tax interactome data from this work and previous studies. Data sheet 2: HBZ interactome data from this work and previous studies. Data sheet 3: Results of the Y2H screen for Tax and mutant constructs. Data sheet 4: Results of the Y2H screen
Benoit Charloteaux (87758) +24 more
core +1 more source
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
The Mammalian Septin Interactome [PDF]
Frontiers in Cell and Developmental Biology, 2017 Septins are GTP-binding and membrane-interacting proteins with a highly conserved domain structure involved in various cellular processes, including cytoskeleton organization, cytokinesis, and membrane dynamics. To date, 13 different septin genes have been identified in mammals (SEPT1 to SEPT12 and SEPT14), which can be classified into four distinct ...
Neubauer, Katharina, Zieger, Barbara
openaire +3 more sources
MiGiNull/Ece1p-interactome: v1.0
<p>Network and Functional Analysis of Ece1p-Human Interactome for Novel Target Identification</p ...
MiGiNull
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Advanced Science, EarlyView.ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei +11 more
wiley +1 more source
Proteomes, 2018 Drug addiction is a complex disorder driven by dysregulation in molecular signaling across several different brain regions. Limited therapeutic options currently exist for treating drug addiction and related psychiatric disorders in clinical populations,
Luis A. Natividad +3 more
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