Sulfatide with ceramide composed of phytosphingosine (t18:0) and 2-hydroxy FAs in renal intercalated cells [PDF]
Journal of Lipid Research, 2022 Diverse molecular species of sulfatide with differences in FA lengths, unsaturation degrees, and hydroxylation statuses are expressed in the kidneys. However, the physiological functions of specific sulfatide species in the kidneys are unclear.
Keiko Nakashima +15 more
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Renal Intercalated Cells: Alien Cells Inside Us? [PDF]
BiologyMammalian renal intercalated cells are known for their role in acid secretion and maintaining acid–base balance. Herein, we discuss the theoretical reasons behind their development based on published data, focusing on the unique characteristics of renal ...
Miguel Luis Graciano
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Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli [PDF]
Nature Communications, 2021 Kidney intercalated cells are involved in acid-base homeostasis in the kidneys. Here, the authors use single cell transcriptomics and find that interalated cells exhibit a transcriptional response conducive to defense and can engulf and acidify ...
Vijay Saxena +10 more
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Deletion of ErbB4 Disrupts Synaptic Transmission and Long-Term Potentiation of Thalamic Input to Amygdalar Medial Paracapsular Intercalated Cells [PDF]
Frontiers in Synaptic Neuroscience, 2021 Identification of candidate risk genes and alteration in the expression of proteins involved in regulating inhibitory neuron function in various psychiatric disorders, support the notion that GABAergic neuron dysfunction plays an important role in ...
Douglas Asede +4 more
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Renal intercalated cells and blood pressure regulation [PDF]
Kidney Research and Clinical Practice, 2017 Type B and non-A, non-B intercalated cells are found within the connecting tubule and the cortical collecting duct. Of these cell types, type B intercalated cells are known to mediate Cl⁻ absorption and HCO₃⁻ secretion largely through pendrin-dependent ...
Susan M. Wall
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Renal type a intercalated cells contain albumin in organelles with aldosterone-regulated abundance. [PDF]
PLoS ONE, 2015 Albumin has been identified in preparations of renal distal tubules and collecting ducts by mass spectrometry. This study aimed to establish whether albumin was a contaminant in those studies or actually present in the tubular cells, and if so, identify ...
Thomas Buus Jensen +4 more
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Renal intercalated cells sense and mediate inflammation via the P2Y14 receptor. [PDF]
PLoS ONE, 2015 Uncontrolled inflammation is one of the leading causes of kidney failure. Pro-inflammatory responses can occur in the absence of infection, a process called sterile inflammation.
Anie Azroyan +9 more
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The Renal Physiology of Pendrin-Positive Intercalated Cells
Physiological Reviews, 2020 Susan Wall +2 more
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KCC3a, a Strong Candidate Pathway for K+ Loss in Alkalemia
Frontiers in Cell and Developmental Biology, 2022 Loss-of-function mutations in the human potassium chloride cotransporter-3 (KCC3) cause a hereditary motor sensory neuropathy associated with agenesis of the corpus callosum. While recapitulating the neuropathy, KCC3-knockout mice also exhibit high blood
Mohammed Zubaerul Ferdaus +3 more
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Frontiers in Physiology, 2023 Tuberous Sclerosis Complex (TSC) is an autosomal dominant genetic disease caused by mutations in either TSC1 or TSC2 genes. Approximately, two million individuals suffer from this disorder worldwide.
Manoocher Soleimani, Manoocher Soleimani
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