Results 11 to 20 of about 4,462,360 (287)

Organization of collecting duct intercalated cells [PDF]

Kidney International, 1990
Our understanding of the mechanisms by which the collecting duct transports HCO3 continues to evolve rapidly. The models put forth in Figure 1, though esthetically pleasing by virtue of their simplicity, will undoubtedly require modification as the above areas and others continue to be explored.
Schuster, Victor L.
openaire   +3 more sources

Intercalated Cells: More than pH Regulation

Diseases, 2014
The renal collecting duct is the nephron segment where the final urine content of acid equivalents and inorganic ions are determined. The role of two different cell types present in this nephron segment has been determined many years ago: principal cells
Ensaf Y. Almomani, Sumanpreet Kaur, R. Todd Alexander, Emmanuelle Cordat   +3 more
doaj   +2 more sources

Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex. [PDF]

Proc Natl Acad Sci U S A, 2021
Barone S, Zahedi K, Brooks M, Henske EP, Yang Y, Zhang E, Bissler JJ, Yu JJ, Soleimani M.   +8 more
europepmc   +2 more sources

L-WNK1 is required for BK channel activation in intercalated cells.

Am J Physiol Renal Physiol, 2021
Ray EC, Carrisoza-Gaytan R, Al-Bataineh M, Marciszyn AL, Nkashama LJ, Chen J, Winfrey A, Griffiths S, Lam TR, Flores D, Wu P, Wang W, Huang CL, Subramanya AR, Kleyman TR, Satlin LM.   +15 more
europepmc   +2 more sources

Bicarbonate is the primary inducer of KCC3a expression in renal cortical B-type intercalated cells.

Am J Physiol Cell Physiol, 2023
Ferdaus MZ, Terker AS, Koumangoye R, Wall SM, Delpire E.   +4 more
europepmc   +2 more sources

A Comparative Kidney Transcriptome Analysis of Bicarbonate-Loaded insrr-Null Mice

Current Issues in Molecular Biology, 2023
The maintenance of plasma pH is critical for life in all organisms. The kidney plays a critical role in acid–base regulation in vertebrates by controlling the plasma concentration of bicarbonate. The receptor tyrosine kinase IRR (insulin receptor-related
E. A. Gantsova, O. V. Serova, D. Eladari, D. M. Bobrovskiy, A. G. Petrenko, A. V. Elchaninov, I. E. Deyev   +6 more
doaj   +1 more source

KCC3a, a Strong Candidate Pathway for K+ Loss in Alkalemia

Frontiers in Cell and Developmental Biology, 2022
Loss-of-function mutations in the human potassium chloride cotransporter-3 (KCC3) cause a hereditary motor sensory neuropathy associated with agenesis of the corpus callosum. While recapitulating the neuropathy, KCC3-knockout mice also exhibit high blood
Mohammed Zubaerul Ferdaus, Andrew Scott Terker, Rainelli Koumangoye, Eric Delpire   +3 more
doaj   +1 more source

Light and heavy ferritin chain expression in the liver and kidneys of Wistar rats: aging, sex differences, and impact of gonadectomy

Arhiv za Higijenu Rada i Toksikologiju, 2022
Ferritin is the main intracellular storage of iron. Animal studies show that female liver and kidney express more ferritin and accumulate more iron than male. However, no study so far has investigated sex and age differences in light (FtL) and heavy (FtH)
Vulinović Mirela Pavić, Turčić Petra, Micek Vedran, Ljubojević Marija   +3 more
doaj   +1 more source

Not all kidney cysts are created equal: a distinct renal cystogenic mechanism in tuberous sclerosis complex (TSC)

Frontiers in Physiology, 2023
Tuberous Sclerosis Complex (TSC) is an autosomal dominant genetic disease caused by mutations in either TSC1 or TSC2 genes. Approximately, two million individuals suffer from this disorder worldwide.
Manoocher Soleimani, Manoocher Soleimani
doaj   +1 more source

Tortuous Cardiac Intercalated Discs Modulate Ephaptic Coupling [PDF]

, 2022
Cardiac ephaptic coupling, a mechanism mediated by negative electric potentials occurring in the narrow intercellular clefts of intercalated discs, can influence action potential propagation by modulating the sodium current. Intercalated discs are highly
Kucera, Jan P., Ena Ivanovic, Jan P. Kucera, Ivanovic, Ena, Kucera, Jan P   +4 more
core   +2 more sources