Results 1 to 10 of about 10,374 (163)

Synthesis of Acridine-based DNA Bis-intercalating Agents [PDF]

Molecules, 2001
Methods for the synthesis of N1, N8-bis(9-acridinyl)-N4-(4-hydroxybenzyl)-spermidine and N1, N7-(hydroxybenzyl)-bis-(3-aminopropyl)amine were investigated.
P. Mack, David P. Kelly, Gerard P. Moloney   +2 more
doaj   +2 more sources

Tumour initiated purinergic signalling promotes cardiomyocyte RBFOX1 degradation and cardiotoxicity from DNA damaging anticancer agents [PDF]

Nature Communications
It is well established tumour cells secrete signalling factors affecting distant normal tissues. What remains unresolved is whether these factors initiate a signalling cascade rendering terminally differentiated cardiomyocytes susceptible to apoptosis, a
Saymon Tejay, Maria Areli Lorenzana-Carrillo, Guocheng Huang, Seyed Amirhossein Tabatabaei Dakhili, Yuan -Yuan Zhao, Farah Eaton, Michelle Mendiola Pla, Dawn E. Bowles, Adam Kinnaird, D. Ian Paterson, Edith Pituskin, John R. Ussher, Evangelos D. Michelakis, Gopinath Sutendra   +13 more
doaj   +2 more sources

Benzofuran-Annulated Naphthalimides Trigger Replication Stress, DNA Damage, and p53-Dependent Cell Cycle Arrest [PDF]

Pharmaceutics
Background/Objectives: DNA-targeting small molecules that induce replication stress represent a promising strategy in anticancer drug development.
Zlatina Vlahova, Lazar Lazarov, Maria Petrova, Shazie Yusein-Myashkova, Jordana Todorova, Maria Schröder, Monika Mutovska, Stanimir Stoyanov, Yulian Zagranyarski, Iva Ugrinova   +9 more
doaj   +2 more sources

Evaluation of Docking Machine Learning and Molecular Dynamics Methodologies for DNA-Ligand Systems

Pharmaceuticals, 2022
DNA is a molecular target for the treatment of several diseases, including cancer, but there are few docking methodologies exploring the interactions between nucleic acids with DNA intercalating agents.
Tiago Alves de Oliveira, Lucas Rolim Medaglia, Eduardo Habib Bechelane Maia, Letícia Cristina Assis, Paulo Batista de Carvalho, Alisson Marques da Silva, Alex Gutterres Taranto   +6 more
doaj   +1 more source

Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo studies

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
This research presents the design and synthesis of a novel series of phthalazine derivatives as Topo II inhibitors, DNA intercalators, and cytotoxic agents.
Mohamed M. Khalifa, Ahmed A. Al-Karmalawy, Eslam B. Elkaeed, Mohamed S. Nafie, Mohamed A. Tantawy, Ibrahim H. Eissa, Hazem A. Mahdy   +6 more
doaj   +1 more source

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV

Pharmaceuticals, 2023
Increases in antibiotic usage and antimicrobial resistance occurrence have caused a dramatic reduction in the effectiveness of many frontline antimicrobial treatments.
Scott Grossman, Colin W. G. Fishwick, Martin J. McPhillie   +2 more
doaj   +1 more source

Agarose gel electrophoresis to assess PCR product yield: comparison with spectrophotometry, fluorometry and qPCR

BioTechniques, 2022
Agarose gel electrophoresis is a relatively easy to use method, commonly applied to evaluate PCR reaction success. Intercalating agents or dyes are used to visualize the amplified fragments. However, it is uncertain to what extent the brightness of bands
Patrick Wittmeier, Susanne Hummel
doaj   +1 more source

Payload diversification: a key step in the development of antibody–drug conjugates

Journal of Hematology & Oncology, 2023
Antibody–drug conjugates (ADCs) is a fast moving class of targeted biotherapeutics that currently combines the selectivity of monoclonal antibodies with the potency of a payload consisting of cytotoxic agents. For many years microtubule targeting and DNA-
Louise Conilh, Lenka Sadilkova, Warren Viricel, Charles Dumontet   +3 more
doaj   +1 more source

Radiosensitization by the novel DNA intercalating agent vosaroxin [PDF]

Radiation Oncology, 2012
Vosaroxin is a first in class naphthyridine analog structurally related to quinolone antibacterials, that intercalates DNA and inhibits topoisomerase II. Vosaroxin is not a P-glycoprotein receptor substrate and its activity is independent of p53, thus evading common drug resistance mechanisms.
Gordon Ira K, Graves Christian, Kil Whoon J, Kramp Tamalee, Tofilon Philip, Camphausen Kevin   +5 more
openaire   +3 more sources

2,4-Dichlorophenoxyacetic Thiosemicarbazides as a New Class of Compounds against Stomach Cancer Potentially Intercalating with DNA

Biomolecules, 2020
Thiosemicarbazide is a useful structural moiety that has the biological potential. Optimization of this structure can result in groundbreaking discovery of a new class of therapeutic agents.
Monika Pitucha, Agnieszka Korga-Plewko, Pawel Kozyra, Magdalena Iwan, Agnieszka A. Kaczor   +4 more
doaj   +1 more source