Results 21 to 30 of about 1,371,077 (290)

Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription

eLife, 2018
Recent studies have challenged the prevailing dogma that transcription is repressed during mitosis. Transcription was also proposed to sustain a robust spindle assembly checkpoint (SAC) response.
Marco Novais-Cruz, Maria Alba Abad, Wilfred FJ van IJcken, Niels Galjart, A Arockia Jeyaprakash, Helder Maiato, Cristina Ferrás   +6 more
doaj   +1 more source

Green and simple production of graphite intercalation compound used sodium bicarbonate as intercalation agent

BMC Chemistry, 2022
AbstractIn view of the technical difficulties in the preparation of graphite intercalation compound (GIC) such as complex processes, the need to use strong acid reagents, and the product containing corrosive elements. A novel, efficient and simple method used sodium bicarbonate as intercalation agent was developed, which combined with mechanical force ...
Xin Wang, Guogang Wang, Long Zhang
openaire   +3 more sources

Electrochemical Biosensors for Detection of MicroRNA as a Cancer Biomarker: Pros and Cons

Biosensors, 2020
Cancer is the second most fatal disease in the world and an early diagnosis is important for a successful treatment. Thus, it is necessary to develop fast, sensitive, simple, and inexpensive analytical tools for cancer biomarker detection.
Maliana El Aamri, Ghita Yammouri, Hasna Mohammadi, Aziz Amine, Hafsa Korri-Youssoufi   +4 more
doaj   +1 more source

Platinum Intercalators of DNA as Anticancer Agents [PDF]

European Journal of Inorganic Chemistry, 2017
The drawbacks of the platinum chemotherapy agents cisplatin, carboplatin and oxaliplatin have inspired the development of compounds with different mechanisms of action. Polyaromatic platinum complexes (PPCs) are a promising anticancer alternative; these bind reversibly with DNA through the insertion of a planar aromatic moiety between nucleobases in a ...
Benjamin J. Pages, K. Benjamin Garbutcheon‐Singh, Janice R. Aldrich‐Wright   +2 more
openaire   +2 more sources

AN INSIGHT INTO MEDICINAL PROPERTIES OF QUINOXALINE SCAFFOLD, WITH A FOCUS ON THEIR ANTICANCER POTENTIAL AS INTERCALATING AGENTS [PDF]

Al-Azhar Journal of Pharmaceutical Sciences
The antitumor properties of synthetic heterocyclic compounds are among the most important properties that can be made use in medicinal chemistry. More specifically, their significant cytotoxic effects against many types of human tumor cells, as well as ...
Mohammed Dahab, Mohammed Abdel Hamid, Ibrahim Eissaa, Mohammed Mohammed   +3 more
doaj   +1 more source

Anthracyclines

WikiJournal of Medicine, 2018
Anthracyclines are a clinically important class of antineoplastic agents used to treat a wide variety of solid and blood cancers. The first described anthracycline, daunorubicin, was first isolated from a strain of Streptomyces peucetius in the early ...
Alison Cheong, Sean McGrath, Suzanne Cutts   +2 more
doaj   +1 more source

From a Co-Mo precursor to 1H and 1T Co-promoted MoS2: exploring the effects of gas pressure

Frontiers in Physics, 2023
The work presented in this paper makes use of the high-pressure in situ imaging capabilities of the ReactorSTM to demonstrate that single layer 1T Co-promoted MoS2 can be directly synthesized without the use of any intercalating agents by applying highly
M. K. Prabhu, I. M. N. Groot
doaj   +1 more source

Transition Metal Intercalators as Anticancer Agents—Recent Advances [PDF]

International Journal of Molecular Sciences, 2016
The diverse anticancer utility of cisplatin has stimulated significant interest in the development of additional platinum-based therapies, resulting in several analogues receiving clinical approval worldwide. However, due to structural and mechanistic similarities, the effectiveness of platinum-based therapies is countered by severe side-effects ...
Deo, Krishant M. (S32272), Pages, Benjamin J. (S31465), Ang, Dale (R17630), Gordon, Christopher P. (R17840), Aldrich-Wright, Janice R. (R7187)   +4 more
openaire   +3 more sources

Effects of artichoke (Cynara scolymus) leaf and bloom head extracts on chemically induced DNA lesions in Drosophila melanogaster

Genetics and Molecular Biology, 2014
The genotoxicity of bloom head (BHE) and leaf (LE) extracts from artichoke (Cynara scolymus L.), and their ability to modulate the mutagenicity and recombinogenicity of two alkylating agents (ethyl methanesulfonate - EMS and mitomycin C - MMC) and the ...
Laura Vicedo Jacociunas, Rafael Rodrigues Dihl, Mauricio Lehmann, Alexandre de Barros Falcão Ferraz, Marc François Richter, Juliana da Silva, Heloísa Helena Rodrigues de Andrade   +6 more
doaj   +1 more source

Topoisomerases inhibition and DNA binding mode of daunomycin–oligoarginine conjugate

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Cancer is a major health issue adsorbing the attention of a biomedical research. To fight this disease, new drugs are developed, specifically tailored to target biological pathways or peculiar components of the tumour cells.
Valeria Visone, Ildikó Szabó, Giuseppe Perugino, Ferenc Hudecz, Zoltán Bánóczi, Anna Valenti   +5 more
doaj   +1 more source