Results 11 to 20 of about 10,129 (256)

Attenuation of cytotoxic natural product DNA intercalating agents by caffeine. [PDF]

Sci Pharm, 2011
Many anti-tumor drugs function by intercalating into DNA. The xanthine alkaloid caffeine can also intercalate into DNA as well as form π-π molecular complexes with other planar alkaloids and anti-tumor drugs. The presence of caffeine could interfere with the intercalating anti-tumor drug by forming π-π molecular complexes with the drug, thereby ...
Hill GM, Moriarity DM, Setzer WN.
europepmc   +4 more sources

Radiosensitization by the novel DNA intercalating agent vosaroxin [PDF]

Radiation Oncology, 2012
Vosaroxin is a first in class naphthyridine analog structurally related to quinolone antibacterials, that intercalates DNA and inhibits topoisomerase II. Vosaroxin is not a P-glycoprotein receptor substrate and its activity is independent of p53, thus evading common drug resistance mechanisms.
Gordon Ira K, Graves Christian, Kil Whoon J, Kramp Tamalee, Tofilon Philip, Camphausen Kevin   +5 more
openaire   +3 more sources

A rare PALB2 germline variant causing G2/M cell cycle arrest is associated with isolated myelosarcoma in infancy

Molecular Genetics & Genomic Medicine, 2021
Background Isolated myelosarcoma of infancy is a rare presentation of acute myelogenous leukaemia (AML). Because of its rarity and early onset in infancy underlying genetic predisposition is potentially relevant in disease initiation. Methods and Results
Angelina Beer, Ricardo Beck, Anne Schedel, Malte vonBonin, Jörn Meinel, Ulrike Anne Friedrich, Maria Menzel, Meinolf Suttorp, Sebastian Brenner, Guido Fitze, Björn Lange, Ralf Knöfler, Julia Hauer, Franziska Auer   +13 more
doaj   +1 more source

Crystal Structures of DNA Intercalating Agents Dipyrido[3,2-f:2′,3′-h]quinoxaline (dpq), (Benzo[i]dipyrido[3,2-a:2′,3′c]phenazine (dppn), and [Ir(ppy)₂(dppn)][PF₆] (Where Hppy = 2-Phenylpyridine)

Inorganics, 2023
Pyrazino-phenanthroline ligands are commonly used with transition metals as DNA intercalation agents. Herein, we report the characterization of two commonly utilized pyrazino-phenanthroline ligands, dipyrido[3,2-f:2′,3′-h]quinoxaline (dpq) and (benzo[i ...
Marisa James, Madelyn R. Shevlin, Thomas B. Green, Megan M. Smart, Colin D. McMillen, Jared A. Pienkos   +5 more
doaj   +1 more source

Platinum Intercalators of DNA as Anticancer Agents [PDF]

European Journal of Inorganic Chemistry, 2017
The drawbacks of the platinum chemotherapy agents cisplatin, carboplatin and oxaliplatin have inspired the development of compounds with different mechanisms of action. Polyaromatic platinum complexes (PPCs) are a promising anticancer alternative; these bind reversibly with DNA through the insertion of a planar aromatic moiety between nucleobases in a ...
Benjamin J. Pages, K. Benjamin Garbutcheon‐Singh, Janice R. Aldrich‐Wright   +2 more
openaire   +2 more sources

Green and simple production of graphite intercalation compound used sodium bicarbonate as intercalation agent

BMC Chemistry, 2022
AbstractIn view of the technical difficulties in the preparation of graphite intercalation compound (GIC) such as complex processes, the need to use strong acid reagents, and the product containing corrosive elements. A novel, efficient and simple method used sodium bicarbonate as intercalation agent was developed, which combined with mechanical force ...
Xin Wang, Guogang Wang, Long Zhang
openaire   +3 more sources

Câncer e agentes antineoplásicos ciclo-celular específicos e ciclo-celular não específicos que interagem com o DNA: uma introdução Cancer and cell cicle-specific and cell cicle nonspecific anticancer DNA-interactive agents: an introduction

Química Nova, 2005
The chemotherapy agents against cancer may be classified as "cell cycle-specific" or "cell cycle-nonspecific". Nevertheless, several of them have their biological activity related to any kind of action on DNA such as: antimetabolic agents (DNA synthesis ...
Vera Lúcia de Almeida, Andrei Leitão, Luisa del Carmen Barrett Reina, Carlos Alberto Montanari, Claudio Luis Donnici, Míriam Teresa Paz Lopes   +5 more
doaj   +1 more source

Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents. [PDF]

PLoS ONE, 2010
Manipulation of the activity of the p53 tumor suppressor pathway has demonstrated potential benefit in preclinical mouse tumor models and has entered human clinical trials.
Karita Peltonen, Laureen Colis, Hester Liu, Sari Jäämaa, Henna M Moore, Juulia Enbäck, Pirjo Laakkonen, Anne Vaahtokari, Richard J Jones, Taija M af Hällström, Marikki Laiho   +10 more
doaj   +1 more source

Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-ones

Molecules, 2009
Representative benzimidazopyrimidinones were previously reported to be intercalating antitumor agents. In this work, we used 2-substituted 4,10-dihydrobenzo [4,5]imidazo[1,2-α]pyriminin-4-ones for their diversification by regioselective alkylation. Under
Sergey M. Desenko, Vladimir I. Musatov, Svetlana M. Sirko, Nikolay Yu. Gorobets   +3 more
doaj   +1 more source

Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription

eLife, 2018
Recent studies have challenged the prevailing dogma that transcription is repressed during mitosis. Transcription was also proposed to sustain a robust spindle assembly checkpoint (SAC) response.
Marco Novais-Cruz, Maria Alba Abad, Wilfred FJ van IJcken, Niels Galjart, A Arockia Jeyaprakash, Helder Maiato, Cristina Ferrás   +6 more
doaj   +1 more source