Results 11 to 20 of about 1,371,077 (290)

Activation of cGAS-dependent antiviral responses by DNA intercalating agents. [PDF]

Nucleic Acids Res, 2017
Acridine dyes, including proflavine and acriflavine, were commonly used as antiseptics before the advent of penicillins in the mid-1940s. While their mode of action on pathogens was originally attributed to their DNA intercalating activity, work in the ...
Pépin G, Nejad C, Thomas BJ, Ferrand J, McArthur K, Bardin PG, Williams BR, Williams BR, Gantier MP.   +8 more
europepmc   +2 more sources

Attenuation of cytotoxic natural product DNA intercalating agents by caffeine. [PDF]

Sci Pharm, 2011
Many anti-tumor drugs function by intercalating into DNA. The xanthine alkaloid caffeine can also intercalate into DNA as well as form π-π molecular complexes with other planar alkaloids and anti-tumor drugs. The presence of caffeine could interfere with
Hill GM, Moriarity DM, Setzer WN.
europepmc   +2 more sources

Intercalating-Organic-Cation-Induced Stability Bowing in Quasi-2D Metal-Halide Perovskites

, 2021
Quasi-2D metal-halide perovskites with Ruddlesden–Popper structures have shown promising stability due to the protective effects of the intercalating organic cations. However, a systematic study of the effect of intercalating organic cations on stability
Stefan Langner, Manuel Daum, Jens A. Hauch (11786281), Jiyun Zhang (11786275), Manuel Daum (11786278), Ning Li (45258), Larry Lüer, Jiyun Zhang, Wei Meng (505670), Wei Meng, Andres Osvet (1511569), Baolin Zhao, Jens A. Hauch, Jianchang Wu (6990641), Christian Kupfer, Chao Liu, Baolin Zhao (11066943), Marcus Halik (1564279), Tobias Stubhan, Christoph J. Brabec, Yicheng Zhao, Christoph J. Brabec (1521265), Marcus Halik, Larry Lüer (1299345), Stefan Langner (2637790), Tobias Stubhan (1356684), Jianchang Wu, Yicheng Zhao (1341948), Ning Li, Christian Kupfer (10906576), Chao Liu (43092), Andres Osvet   +31 more
core   +2 more sources

Crystal Structures of DNA Intercalating Agents Dipyrido[3,2-f:2′,3′-h]quinoxaline (dpq), (Benzo[i]dipyrido[3,2-a:2′,3′c]phenazine (dppn), and [Ir(ppy)₂(dppn)][PF₆] (Where Hppy = 2-Phenylpyridine)

Inorganics, 2023
Pyrazino-phenanthroline ligands are commonly used with transition metals as DNA intercalation agents. Herein, we report the characterization of two commonly utilized pyrazino-phenanthroline ligands, dipyrido[3,2-f:2′,3′-h]quinoxaline (dpq) and (benzo[i ...
Marisa James, Madelyn R. Shevlin, Thomas B. Green, Megan M. Smart, Colin D. McMillen, Jared A. Pienkos   +5 more
doaj   +1 more source

A rare PALB2 germline variant causing G2/M cell cycle arrest is associated with isolated myelosarcoma in infancy

Molecular Genetics & Genomic Medicine, 2021
Background Isolated myelosarcoma of infancy is a rare presentation of acute myelogenous leukaemia (AML). Because of its rarity and early onset in infancy underlying genetic predisposition is potentially relevant in disease initiation. Methods and Results
Angelina Beer, Ricardo Beck, Anne Schedel, Malte vonBonin, Jörn Meinel, Ulrike Anne Friedrich, Maria Menzel, Meinolf Suttorp, Sebastian Brenner, Guido Fitze, Björn Lange, Ralf Knöfler, Julia Hauer, Franziska Auer   +13 more
doaj   +1 more source

Molecular modelling assisted design of napthalimide-dihydropyrimidinone conjugates as potential cytotoxic agents

Journal of Saudi Chemical Society, 2021
A molecular modelling assisted design of napthalimide-dihydropyrimidinone conjugates as potential cytotoxic agents based on a lead molecule (elinafide) is described.
M. Shaheer Malik, Syed Farooq Adil, Zaki S. Seddigi, Moataz Morad, Rabab S. Jassas, Ismail I. Thagafi, Hatem M. Altass, Qazi Mohammad Sajid Jamal, Syed Riyaz, Reem I. Alsantali, Abdulrahman A. Al-Warthan, Mohammad Azam Ansari, Saleh A. Ahmed   +12 more
doaj   +1 more source

DNA/RNA intercalating agents as antivirotics: possible mechanisms of action [PDF]

, 2021
DNA/RNA intercalating agents are compounds with capability to insert themself between nucleic acids base pairs. This phenomenon is accompanied by structural or functional disruption of said nucleic acid.
Kropáček, Václav
core  

Câncer e agentes antineoplásicos ciclo-celular específicos e ciclo-celular não específicos que interagem com o DNA: uma introdução Cancer and cell cicle-specific and cell cicle nonspecific anticancer DNA-interactive agents: an introduction

Química Nova, 2005
The chemotherapy agents against cancer may be classified as "cell cycle-specific" or "cell cycle-nonspecific". Nevertheless, several of them have their biological activity related to any kind of action on DNA such as: antimetabolic agents (DNA synthesis ...
Vera Lúcia de Almeida, Andrei Leitão, Luisa del Carmen Barrett Reina, Carlos Alberto Montanari, Claudio Luis Donnici, Míriam Teresa Paz Lopes   +5 more
doaj   +1 more source

Identification of novel p53 pathway activating small-molecule compounds reveals unexpected similarities with known therapeutic agents. [PDF]

PLoS ONE, 2010
Manipulation of the activity of the p53 tumor suppressor pathway has demonstrated potential benefit in preclinical mouse tumor models and has entered human clinical trials.
Karita Peltonen, Laureen Colis, Hester Liu, Sari Jäämaa, Henna M Moore, Juulia Enbäck, Pirjo Laakkonen, Anne Vaahtokari, Richard J Jones, Taija M af Hällström, Marikki Laiho   +10 more
doaj   +1 more source

Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-ones

Molecules, 2009
Representative benzimidazopyrimidinones were previously reported to be intercalating antitumor agents. In this work, we used 2-substituted 4,10-dihydrobenzo [4,5]imidazo[1,2-α]pyriminin-4-ones for their diversification by regioselective alkylation. Under
Sergey M. Desenko, Vladimir I. Musatov, Svetlana M. Sirko, Nikolay Yu. Gorobets   +3 more
doaj   +1 more source