Results 91 to 100 of about 665,109 (406)

DHT deficiency perturbs the integrity of the rat seminiferous epithelium by disrupting tight and adherens junctions

Folia Histochemica et Cytobiologica, 2011
In rats with a DHT deficiency induced by finasteride, morphological changes in the seminiferous epithelium were observed. The structural alterations were manifested by the premature germ cells sloughing into the lumen of seminiferous tubules.
Barbara Wiszniewska, Lidia Wenda-Różewicka, Mariola Marchlewicz, Agnieszka Kolasa   +3 more
doaj   +1 more source

Intercellular Adhesive Structures Between Stellate Cells – An Analysis in Cultured Human Hepatic Stellate Cells [PDF]

, 2004
To investigate whether or not hepatic stellate cells can form intercellular junctions with each other, we cultured human stellate cells (LI90) on different kinds of substrata. Intercellular junctions were detected between these cultured stellate cells by
Higashi, Nobuyo, Imai, Katsuyuki, Kojima, Naosuke, Miura, Mitsutaka, Sato, Mitsuru, Sato, Takeya, Senoo, Haruki, Suzuki, Shinsuke, Wang, Da-Ren   +8 more
core   +2 more sources

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Metallothionein 2 activation by pravastatin reinforces epithelial integrity and ameliorates radiation-induced enteropathy

EBioMedicine, 2021
: Background: Radiotherapy or accidental exposure to ionizing radiation causes severe damage of healthy intestinal tissues. Intestinal barrier function is highly sensitive to ionizing radiation, and loss of epithelial integrity results in mucosal ...
Seo Young Kwak, Won Il Jang, Seungwoo Park, Sang Sik Cho, Seung Bum Lee, Min-Jung Kim, Sunhoo Park, Sehwan Shim, Hyosun Jang   +8 more
doaj  

The Peptidoglycan-Binding Protein SjcF1 Influences Septal Junction Function and Channel Formation in the Filamentous Cyanobacterium Anabaena

mBio, 2015
Filamentous, heterocyst-forming cyanobacteria exchange nutrients and regulators between cells for diazotrophic growth. Two alternative modes of exchange have been discussed involving transport either through the periplasm or through septal junctions ...
Mareike Rudolf, Nalan Tetik, Félix Ramos-León, Nadine Flinner, Giang Ngo, Mara Stevanovic, Mireia Burnat, Rafael Pernil, Enrique Flores, Enrico Schleiff   +9 more
doaj   +1 more source

Layered defense: how mucus and tight junctions seal the intestinal barrier

Journal of molecular medicine, 2017
The colonic mucosa provides a vital defensive barrier separating the body from the microbial populations residing in the intestinal lumen. Indeed, growing evidence shows that loss of this barrier may cause disease or exacerbate disease progression.
Christopher T. Capaldo, Domonica N. Powell, D. Kalman   +2 more
semanticscholar   +1 more source

Collective cell migration: Implications for wound healing and cancer invasion. [PDF]

, 2013
During embryonic morphogenesis, wound repair and cancer invasion, cells often migrate collectively via tight cell-cell junctions, a process named collective migration.
He, Yong, Jiang, Jianxin, Li, Li, Zhao, Min   +3 more
core   +2 more sources

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family [PDF]

, 2009
Background: Tight junctions are an intercellular adhesion complex of epithelial and endothelial cells, and form a paracellular barrier that restricts the diffusion of solutes on the basis of size and charge.
Balda, M.S., Matter, K., Rodrigues, N.T.L., Steed, E.   +3 more
core   +3 more sources

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source