Results 31 to 40 of about 48,349 (272)

Ennobling Interchanges

Primerjalna književnost, 2019
This paper draws on the poetic concept of the oneness of the self and the world, as elaborated through Coleridge’s reading of German romantic philosophers by the poet William Wordsworth. In his poem “Prelude” he rejects simple materialism and simple spiritualism, just as Schelling rejected the extreme views that the spiritual self creates the world or ...
openaire   +3 more sources

Experimental Evaluation of Interchangeability in Soft CSPs [PDF]

, 2006
In [8], Freuder defined interchangeability for classical Constraint Satisfaction Problems (CSPs). Recently [2], we extended the definition of interchangeability to Soft CSPs and we introduced two notions of relaxation based on degradation # and on ...
Boi Faltings, Nicoleta Neagu, Stefano Bistarelli   +2 more
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

A phase 4, open-label study to evaluate the safety and immunogenicity of DTaP5-HBV-IPV-Hib in children previously vaccinated with DTaP2-HBV-IPV-Hib or DTaP5-HBV-IPV-Hib (V419-016)

Human Vaccines & Immunotherapeutics
DTaP5-HBV-IPV-Hib (Vaxelis®) is a hexavalent combination vaccine (HV) indicated in infants and toddlers for the prevention of diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis, and invasive disease due to Haemophilus influenzae type b. Switching
Andrea Guerra, Claudio Costantino, Federico Martinon-Torres, Soeren Westerholt, Courtney Lambeth, Ziqiang Chen, Jessie Lumley, Tomas Marcek, David Johnson, Marissa Wilck   +9 more
doaj   +1 more source

EAGLE ISS - A modular twin-channel integral-field near-IR spectrograph

, 2010
The ISS (Integral-field Spectrograph System) has been designed as part of the EAGLE Phase A Instrument Study for the E-ELT. It consists of two input channels of 1.65x1.65 arcsec field-of-view, each reconfigured spatially by an image-slicing integral ...
Evans, C. J., Hastings, P. R., Stobie, B., Vives, S., Vola, P., Wells, M.   +5 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Knowledge and perception of biosimilars in ambulatory care: a survey among Belgian community pharmacists and physicians

Journal of Pharmaceutical Policy and Practice, 2021
Background With the approval of biosimilars for subcutaneously administered products, such as adalimumab, etanercept and insulin, biosimilars become increasingly available in ambulatory care.
Liese Barbier, Yannick Vandenplas, Steven Simoens, Paul Declerck, Arnold G. Vulto, Isabelle Huys   +5 more
doaj   +1 more source