Results 41 to 50 of about 48,481 (274)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

A phase 4, open-label study to evaluate the safety and immunogenicity of DTaP5-HBV-IPV-Hib in children previously vaccinated with DTaP2-HBV-IPV-Hib or DTaP5-HBV-IPV-Hib (V419-016)

open access: yesHuman Vaccines & Immunotherapeutics
DTaP5-HBV-IPV-Hib (Vaxelis®) is a hexavalent combination vaccine (HV) indicated in infants and toddlers for the prevention of diphtheria, tetanus, pertussis, hepatitis B, poliomyelitis, and invasive disease due to Haemophilus influenzae type b. Switching
Andrea Guerra   +9 more
doaj   +1 more source

Synonymous Structures in English Syntax

open access: yesArmenian Folia Anglistika, 2018
Synonymy is one of the most important sources of the wealth of language and is closely related to the problems of stylistics, speech culture, language changes and language improvements.
Jemma Militonyan
doaj   +1 more source

Bell's inequality test with time-delayed two-particle correlations [PDF]

open access: yes, 2008
Adopting the frame of mesoscopic physics, we describe a Bell type experiment involving time-delayed two-particle correlation measurements. The indistinguishability of quantum particles results in a specific interference between different trajectories. We
A. V. Lebedev   +3 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

open access: yesFEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo   +4 more
wiley   +1 more source

Observing Shape in Spacetime [PDF]

open access: yes, 2014
The notion of "reference frame" is a central theoretical construct for interpreting the physical implications of spacetime diffeomorphism invariance in General Relativity.
Gryb, Sean
core   +4 more sources

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

The biosimilars journey: current status and ongoing challenges

open access: yesDrugs in Context, 2018
Biosimilar products are already approved and marketed in several countries. The Food and Drug Administration has approved ten different biosimilars, and the European Medicines Agency has approved 40.
Igor Age Kos   +3 more
doaj   +1 more source

Historical Gloss and the Separation of Powers [PDF]

open access: yes, 2012
Arguments based on historical practice are a mainstay of debates about the constitutional separation of powers. Surprisingly, however, there has been little sustained academic attention to the proper role of historical practice in this context. The scant
Bradley, Curtis A., Morrison, Trevor W.
core   +4 more sources

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