Results 81 to 90 of about 48,349 (272)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
The biosimilars journey: current status and ongoing challenges
Drugs in Context, 2018 Biosimilar products are already approved and marketed in several countries. The Food and Drug Administration has approved ten different biosimilars, and the European Medicines Agency has approved 40.
Igor Age Kos +3 more
doaj +1 more source
First-Order Decomposition Trees [PDF]
, 2013 Lifting attempts to speed up probabilistic inference by exploiting symmetries in the model. Exact lifted inference methods, like their propositional counterparts, work by recursively decomposing the model and the problem. In the propositional case, there
Blockeel, Hendrik +2 more
core
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Interchange systems. Interchanges. Used terminology
Dorogi i mostiSummary Introduction. In the introduction to the paper, the common questions concerning the assurance of the terminological congruence of national standards’ provisions, when being harmonized, with provisions of regional or international standards were outlined and also important sources of appropriate regional information in the sector of the ...
openaire +1 more source
Efficient structural symmetry breaking for constraint satisfaction problems [PDF]
, 2007 Symmetry breaking for constraint satisfaction problems (CSPs) has attracted considerable attention in recent years. Various general schemes have been proposed to eliminate symmetries.
Flener, Pierre +4 more
core +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Experimental Evaluation of Branching Schemes for the CSP
, 2010 The search strategy of a CP solver is determined by the variable and value ordering heuristics it employs and by the branching scheme it follows. Although the effects of variable and value ordering heuristics on search effort have been widely studied ...
Balafoutis, Thanasis +2 more
core
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
EXPRESS METHOD FOR DETERMINATION OF ENALAPRIL AND ENALAPRILAT IN HUMAN SERUM BY HPLC-MS/MS
Разработка и регистрация лекарственных средств, 2019 The express method for simultaneous determination of enalapril and enalaprilat in human serum using HPLC-MS/MS is proposed. A simple sample preparation procedure, short analysis time, and a wide analytical range for both analytes (5.00 to 250.00 ng/mL ...
T. A. Rodina +5 more
doaj