Results 41 to 50 of about 306,084 (179)

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source

Eradicating chronic Hepatitis C Viraemia : lessons learnt during the last decade [PDF]

, 2005
Over the last decade a better understanding of the mechanism for immune disposal of hepatocytes infected with the Hepatitis C virus enabled the design of antiviral regimens with increasing efficacy.
Pullicino, Edgar
core  

Subcutaneous Sarcoidosis during Pegylated Interferon Alfa and Ribavirin Treatment for Chronic Hepatitis C

Dermatology Research and Practice, 2010
Interferon is used to treat hepatitis C virus infection and its cutaneous side effects are well known. Recently, interferon-induced sarcoidosis has been reported.
R. Rodríguez-Lojo, M. Almagro, J. M. Barja, F. Piñeyro, L. Pérez-Varela, J. Del Pozo, M. T. Yebra-Pimentel, E. Fonseca   +7 more
doaj   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Responses to peginterferon alfa-2a vs alfa-2b plus ribavirin in a Mexican population with chronic hepatitis C

Journal of Infection in Developing Countries, 2015
Introduction: The WHO estimates that 180 million people are chronically infected with hepatitis C virus (HCV) throughout the world. Despite the emergence of new therapies, the combination of pegylated interferon and ribavirin remains the accepted ...
Jorge Luis Sandoval-Ramirez, José Antonio Mata-Marín, Gloria Huerta García, Jesús Enrique Gaytán-Martínez   +3 more
doaj   +1 more source

Clinical progress note: Mumps

Journal of Hospital Medicine, EarlyView.
Abstract Mumps was a common childhood viral illness before the implementation of the measles, mumps, and rubella (MMR) vaccination in 1967. There was a significant decrease in mumps cases in the postvaccine era; however, there has been an increase in outbreaks in the United States over the past two decades.
Sarah Ludvigsen, Mati Segev
wiley   +1 more source

Response prediction in chronic hepatitis C by assessment of IP-10 and IL28B-related single nucleotide polymorphisms [PDF]

, 2011
Background: High baseline levels of IP-10 predict a slower first phase decline in HCV RNA and a poor outcome following interferon/ribavirin therapy in patients with chronic hepatitis C.
Askarieh Galia, Neumann, A.U. (Avidan), Söderholm, Jonas,, Magnus Lindh, Avidan U Neumann, Stephanie Bibert, Soderholm, J, Askarieh, Galia,, Romero, A. (Ana), Group, DITTO-HCV Study, Jean-Michel Pawlotsky, Lindh, M., Negro, F, Söderholm, J., Lindh, M, Missale, Gabriele, Lagging, Martin,, Askarieh, G., Haagmans, Bart L, Romero, Ana, Hellstrand, K. (Kristoffer), Bochud Pierre-Yves, Lagging, Martin, Romero, A, null null, Söderholm Jonas, Haagmans, Bart L., Neumann, AU (Avidan), Gabriele Missale, Ferrari, C., Negro, F., Pawlotsky, J.M., Lindh Magnus, Negro Francesco, Avidan U. Neumann, Pierre-Yves Bochud, Lindh, Magnus, Johan Westin, Zeuzem Stefan, Lindh, M. (Magnus), Missale Gabriele, Bochud, Pierre Yves, Bibert, S., Bochud, P.Y., Galia Askarieh, Lagging Martin, Ferrari Carlo, Bibert, Stephanie, Hellstrand, Kristoffer, Zeuzem, S., Neumann, Avidan U., Haagmans, B.L., DITTO-HCV Study Group, Neumann, A.U., Lindh, Magnus,, Francesco Negro, Westin, J., Söderholm, J. (Jonas), Zeuzem, S. (Stefan), Söderholm, Jonas, Ferrari, Carlo, Martin Lagging, Neumann Avidan U., Zeuzem, Stefan, Neumann, Avidan U, Zeuzem, S, Hellstrand Kristoffer, Westin, Johan, Bart L Haagmans, Romero, A., Lagging, M. (Martin), Hellstrand, K., Haagmans, Bart, Bibert Stephanie, Hellstrand, K, Bart L. Haagmans, Missale, G. (Gabriele), Pawlotsky, Jean Michel, Pawlotsky, Jean-Michel, Ferrari, C. (Carlo), Carlo Ferrari, Bochud, P-Y. (Pierre-Yves), Haagmans Bart L., Askarieh, G, Lagging, M., Missale, G., Stefan Zeuzem, Kristoffer Hellstrand, Ferrari, C, Westin, J. (Johan), Askarieh, Galia, Bibert, S, Lagging, M, Westin, Johan,, Hellstrand, Kristoffer,, Westin, J, Haagmans, B.L. (Bart), Romero Ana, Jonas Söderholm, Pawlotsky Jean-Michel, Westin Johan, Askarieh, G. (Galia), Negro, Francesco, Bochud, PY, Bochud, Pierre-Yves, Pawlotsky, JM, Pawlotsky, J-M. (Jean-Michel), Missale, G, Romero, Ana,, Ana Romero   +109 more
core   +1 more source

Pityriasis Rosea Associated with Pegylated Interferon Alfa and Ribavirin Treatment in a Patient with Chronic Hepatitis C

Balkan Medical Journal, 2013
Background: Pityriasis rosea is an acute inflamatory skin disease that the etiology is unknown but some viral agents like human herpes virus-6 and 7 and drugs are suspected. Case report: A-58-year-old man with chronic hepatitis C was being followed up
Rahmet Güner, Şiran Keske, İmran Hasanoğlu, Mehmet Taşyaran   +3 more
doaj   +1 more source

Key Interventions in Friedreich's Ataxia and Their Impact on Patient Outcomes: A Systematic Review

Movement Disorders, EarlyView.
Abstract Friedreich's ataxia (FA) is a rare neurodegenerative disease with multisystemic symptoms that requires multidisciplinary care. This systematic review summarizes available pharmacological and nonpharmacological interventions, their outcomes, and alignment with patient‐centered care domains, as well as their impact on these domains.
Dorota Sarwinska, Maresa Buchholz, Audrey Iskandar, Marcus Grobe‐Einsler, Thomas Klockgether, Jennifer Faber, Bernhard Michalowsky   +6 more
wiley   +1 more source

Um Olhar sobre a efetividade e custos do tratamento da hepatite C sob a perspectiva do Sistema Único de Saúde [PDF]

, 2011
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2011Introdução: A prevalência da hepatite C no Brasil é estimada em torno de 1%.
Blatt, Carine Raquel
core