IFN-γ and TNF-α synergize to inhibit CTGF expression in human lung endothelial cells. [PDF]
, 2012 Connective tissue growth factor (CTGF/CCN2) is an angiogenetic and profibrotic factor, acting downstream of TGF-β, involved in both airway- and vascular remodeling.
Fehrholz, Markus +6 more
core +20 more sources
Interferon-gamma inhibits influenza A virus cellular attachment by reducing sialic acid cluster size
iScience, 2022 Summary: The mucosal antiviral role of type I and III interferon in influenza virus infection is well established. However, much less is known about the antiviral mechanism of type II interferon (interferon-gamma).
Carol Ho-Yan Fong +7 more
doaj +1 more source
Molecular characterization of the 3'-UTRsequence of the interferon-gamma gene and its expression profile in the ocular conjunctiva of amazon buffaloes [PDF]
Iraqi Journal of Veterinary Sciences, 2023 Interferon-gamma is an important innate immunomodulatory inflammatory cytokine, whose molecular characterization can demonstrate how this gene may or may not be conserved in populations throughout the evolutionary process.
Laura J. Paredes +8 more
doaj +1 more source
Novel approach to activity evaluation for release-active forms of anti-interferon-gamma antibodies based on enzyme-linked immunoassay. [PDF]
PLoS ONE, 2014 Selection of a suitable assay to measure the activity of drug agents based on release-active forms of anti-interferon-gamma antibodies (RA forms of Abs) is an important step forward in the investigation of such agents.
Elena S Gavrilova +5 more
doaj +1 more source
The Therapeutic potential of interferon-gamma in tuberculosis
ADMET and DMPK, 2022 Tuberculosis is one of the critical health problems worldwide. The search for ways to improve the results of tuberculosis treatment and overcome drug resistance lies in understanding the pathogenesis of the development of the infectious process.
Svetlana A. Berns +2 more
doaj +1 more source
Interferon-γ acutely augments inhibition of neocortical layer 5 pyramidal neurons [PDF]
, 2020 BACKGROUND: Interferon-γ (IFN-γ, a type II IFN) is present in the central nervous system (CNS) under various conditions. Evidence is emerging that, in addition to its immunological role, IFN-γ modulates neuronal morphology, function, and development in ...
Bräuer, Anja U. +7 more
core +1 more source
UMYU Journal of Microbiology Research, 2020 Typhoid fever remains a significant public health challenge in developing countries, including Nigeria. The Widal test, widely used for diagnosing typhoid fever due to its simplicity and quick turnaround time, has raised concerns regarding its ...
Mujahid, N. S. +6 more
doaj +1 more source
Open‐Label Pilot Study of Interferon Gamma–1b in Patients With Non‐Infantile Osteopetrosis
JBMR Plus, 2022 The only treatment currently available for patients with severe infantile osteopetrosis is hematopoietic cell transplantation (HCT). HCT‐related toxicity and mortality risks typically preclude its use in non‐infantile patients, and other therapies are ...
Andrew Nguyen +8 more
doaj +1 more source
Interferon-γ Inhibits Ebola Virus Infection.
PLoS Pathogens, 2015 Ebola virus outbreaks, such as the 2014 Makona epidemic in West Africa, are episodic and deadly. Filovirus antivirals are currently not clinically available.
Bethany A Rhein +11 more
doaj +1 more source
Study of T1 Tobacco Transplastomic Plants Containing Human Gamma Interferon Gene (hIFNg) [PDF]
مجله بیوتکنولوژی کشاورزی, 2014 In the recent decades the progress in plant biotechnology, especially in the field of molecular farming, has made it possible to produce a wide range of recombinant protein using plants as a novel production system and bioreactor.
Mozhgan Soleimani Zadeh +3 more
doaj +1 more source