Results 161 to 170 of about 278,920 (292)

Vasculitic fasciitis characterizes a distinct subset of vasculitic myopathy with interferon-gamma signature. [PDF]

Acta Neuropathol
Ruffer N, Pinal-Fernandez I, Preusse C, Mammen AL, Holzer MT, Kleefeld F, Goebel HH, Casal-Dominguez M, Pak K, Kötter I, Siefert J, Furth C, Feldhaus F, Görl N, Fieber F, Alten R, Huber TB, Casteleyn V, Roos A, Krusche M, Schneider U, Milisenda JC, Stenzel W.   +22 more
europepmc   +1 more source

NAT10‐Mediated ac4C Modification of circANKRD12 Reprograms the Tumor Microenvironment

Advanced Science, EarlyView.
NAT10‐dependent acetylation of circANKRD12 drives translation of the circANKRD12_354aa protein, which binds HDAC2 to stabilize c‐Myc via deubiquitination, promoting multiple myeloma (MM) cell proliferation. Concurrently, the circANKRD12‐HDAC2 axis suppresses H3ac‐mediated transcription of IFN‐γ, TNF‐α, and GZMB in NK cells, leading to NK cell ...
Jiale Zhang, Hui Shi, Chen Wang, Zihao Liu, Lianxin Zhou, Xinyu Lv, Mengjie Guo, Ye Yang, Chunyan Gu   +8 more
wiley   +1 more source

Identification of a robust metabolic signature associated with hospital-acquired pneumonia and response to interferon-gamma treatment in critically ill patients. [PDF]

Crit Care
Petrier M, Sinha D, Martin FP, Poulain C, Flattres Duchaussoy D, Ziogas A, Novakovic B, Hurtado-Navarro L, Ferreira AV, Martens JHA, Koulenti D, Fernández-Barat L, Torres A, Montassier E, Netea MG, Poschmann J, Roquilly A.   +16 more
europepmc   +1 more source

The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation

American Journal of Hematology, EarlyView.
ABSTRACT Allogeneic hematopoietic cell transplantation (allo‐HCT) is an effective treatment for patients with high‐risk hematologic malignancies. Over the last decade, gut microbiota composition during allo‐HCT has been associated with patients' outcomes.
Wenjing Hao, Nicolas Stocker, Béatrice Gaugler, Mohamad Mohty, Florent Malard   +4 more
wiley   +1 more source

Optimization of Recombinant Human Interferon-Gamma Expression and Purification in <i>E. coli</i>, and Developing an Immunization Protocol for the Production of Optimal Humoral Response. [PDF]

Biologics
Uwituze V, Mugasa CM, Namayanja M, Nalumenya DP, Ndayisenga J, Ssekatawa K, Kato CD.   +6 more
europepmc   +1 more source

Variability between countries in cytokine responses to BCG vaccination: what impact might this have on protection?

, 2012
Dockrell, Hazel M, Lalor, Maeve K, Smith, Steven G   +2 more
core   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Integrating interferon gamma receptor pathways, antigenicity, and immune contexture as predictors of immunotherapeutic strategies for mucosal melanomas. [PDF]

J Immunother Cancer
Monti M, Picinoli S, Bozzola A, Ferrari M, Bugatti M, Pezzali I, Carlomagno M, Carta G, Orlandi M, Lora G, Benerini Gatta L, Missale F, Ferrari G, Baldazzi V, Rezzola S, Tabellini G, Parolini S, Manfredi M, De Giorgis V, Marengo E, Turri-Zanoni M, Nicolai P, Consoli F, Lombardi D, Martini P, Li J, Griffith O, Griffith M, Rossato M, Vermi W.   +29 more
europepmc   +1 more source

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

A Deep‐Red‐Absorbing Osmium(II) Complex as a Photosensitizer for Photodynamic Therapy Inducing Immunogenic Cell Death

Angewandte Chemie, EarlyView.
A deep‐red‐excited osmium(II) photosensitizer (Os2) induces immunogenic cell death (ICD) under 740 nm irradiation and triggers robust anti‐tumor immune responses both in vitro and in vivo. ABSTRACT Immunogenic cell death (ICD), which converts tumor cells into their own vaccine, plays a pivotal role in the development of novel anticancer therapies. Here,
Yiyi Zhang, Pierre Mesdom, Eduardo Izquierdo‐García, João P. M. António, Ruonan Gao, Bruno Saubaméa, Johanne Seguin, Morgane Moinard, Philippe Arnoux, Céline Frochot, Kevin Cariou, Bich‐Thuy Doan, Gilles Gasser   +12 more
wiley   +2 more sources