Results 171 to 180 of about 1,206,341 (327)

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

Proceedings of the National Academy of Sciences of the United States of America, 1993
R. Seder, R. Gazzinelli, A. Sher, W. Paul   +3 more
semanticscholar   +1 more source

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

Advanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu   +9 more
wiley   +1 more source

Comment on "Relevance of cerebral microbleeds with leaky blood brain barrier in traumatic brain injury and protective role of interferon-gamma: A cohort study". [PDF]

Cereb Circ Cogn Behav
Manikya S, Vadhithala V, Kumar R, Nainwal P.   +3 more
europepmc   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Long-acting pegylated Interferon Gamma (pegIFNG) sensitizes AML cells to killing by donor T cells.

Vaishali Basu, Gregory Mannino, Laura Mpofu, Heidi Struthers, Sharon J. Carlson, George N. Cox, David H. Spencer, Michael P. Rettig, Matt Christopher   +8 more
openalex   +1 more source

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source

Vasculitic fasciitis characterizes a distinct subset of vasculitic myopathy with interferon-gamma signature. [PDF]

Acta Neuropathol
Ruffer N, Pinal-Fernandez I, Preusse C, Mammen AL, Holzer MT, Kleefeld F, Goebel HH, Casal-Dominguez M, Pak K, Kötter I, Siefert J, Furth C, Feldhaus F, Görl N, Fieber F, Alten R, Huber TB, Casteleyn V, Roos A, Krusche M, Schneider U, Milisenda JC, Stenzel W.   +22 more
europepmc   +1 more source

Prevalence of Tuberculosis Infection by Interferon-Gamma Release Assay and Risk Factors Associated with Latent Tuberculosis Infection among Household Contacts of Pulmonary Tuberculosis Patients in Roi Et Province, Thailand

Sakaren Lawong
openalex   +2 more sources

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source

Identification of a robust metabolic signature associated with hospital-acquired pneumonia and response to interferon-gamma treatment in critically ill patients. [PDF]

Crit Care
Petrier M, Sinha D, Martin FP, Poulain C, Flattres Duchaussoy D, Ziogas A, Novakovic B, Hurtado-Navarro L, Ferreira AV, Martens JHA, Koulenti D, Fernández-Barat L, Torres A, Montassier E, Netea MG, Poschmann J, Roquilly A.   +16 more
europepmc   +1 more source