Results 191 to 200 of about 276,366 (297)

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Diagnostic accuracy of interferon-gamma release assay and mucosal-associated invariant T cells in spinal tuberculosis. [PDF]

Sci Rep
Mekariya K, Ayutthaya PSN, Naowanirut A, Wongsa A, Tassaneetrithep B, Tantibhedhyangkul W, Ngamskulrungroj P, Muangsomboon S, Cheiwvit P, Wilartratsami S, Luksanapruksa P, Danchaivijitr N, Boonchai K, Rattanatanasarn A, Ruangchainikom M.   +14 more
europepmc   +1 more source

Reinforcing Calcium Overload via Inflammation‐Mediated Targeting to Amplify Pyroptosis and Antitumor Immunity

Advanced Science, EarlyView.
A neutrophil‐membrane‐camouflaged nanoplatform (RC@NMVs) exploits tumor inflammation to target and accumulate in tumors. Intracellular Ca2+ overload is triggered via lysosomal CaP dissolution and Ru red‐mediated Ca2+ channel blockade, synergistically inducing gasdermin‐mediated pyroptosis.
Yingying Liu, Yang Liu, Qin Fan, Jinqiao Zhang, Kexin Wen, Boyu Yuan, Xianzhou Cai, Ziliang Dong, Lianhui Wang   +8 more
wiley   +1 more source

Quinovic Acid Enhances the Cytotoxicity of KHYG-1 Cells by Modulating the Ras/MAPK Signalling Pathway and Interferon-Gamma Expression. [PDF]

J Cell Mol Med
Hsieh MJ, Lin JT, Chuang YC, Ho HY, Lo YS, Lin CC, Chen MK.   +6 more
europepmc   +1 more source

Increased yield of porcine circovirus-2 by a combined treatment of PK-15 cells with interferon-gamma and inhibitors of endosomal-lysosomal system acidification [PDF]

, 2008
Delputte, Peter, Lefebvre, David, Misinzo, Gerald, Nauwynck, Hans   +3 more
core  

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Clinical course and outcomes of patients with anti-interferon-gamma autoantibody-associated adult-onset immunodeficiency: an observational cohort study. [PDF]

Ann Med
Angkasekwinai N, Wongsawat E, Vorasan N.
europepmc   +1 more source

Exploring the interactions of Interferon-gamma and polyphenols in colorectal cancer cells [PDF]

Jordan-Mahy, Nikki, Leyland, Rebecca, Owens, Kyle, Peake, Nicholas   +3 more
core  

Engineered TIGIT‐Blockade Membrane Vesicles Synergize with Microwave Ablation to Mediate Liver Metastases Eradication

Advanced Science, EarlyView.
Microwave ablation (MWA) represents a highly effective and clinically significant therapeutic modality for the treatment of liver metastases. This study develops engineered cell membrane vesicles to specifically target the transition zone of MWA for liver metastases. This strategy can inhibit VEGF‐mediated immunosuppression, block CD155/TIGIT signaling
Shaoyue Li, Weichen Xu, Yuting Shen, Xuexia Shan, Jiawei Sun, Shisi Ding, Xiaodong Hou, Shaoning Zhang, Zhiyuan Niu, Taixia Wang, Xin Guan, Xiao Li, Weiwei Ren, Dou Du, Huixiong Xu, Wenwen Yue, Liping Sun   +16 more
wiley   +1 more source

Interferon Gamma: Activity and ELISA Detection Comparisons

BioTechniques, 2008
Sara Crisafulli, Yognandan Pandya, Karlene Moolchan, Thomas B. Lavoie   +3 more
doaj   +1 more source