Pseudomonas aeruginosa Modulates the Antiviral Response of Bronchial Epithelial Cells
Frontiers in Immunology, 2020 Cystic fibrosis (CF) patients frequently acquire Pseudomonas aeruginosa infections that have been associated with a bad prognosis and an increased rate of pulmonary exacerbations.
Michael Sörensen +15 more
doaj +1 more source
Stratification of Systemic Lupus Erythematosus Patients Using Gene Expression Data to Reveal Expression of Distinct Immune Pathways [PDF]
, 2020 Systemic lupus erythematosus (SLE) is the tenth leading cause of death in females 15-24 years old in the US. The diversity of symptoms and immune pathways expressed in SLE patients causes difficulties in treating SLE as well as in new clinical trials.
arxiv +1 more source
Interferon-Gamma at the Crossroads of Tumor Immune Surveillance or Evasion
Frontiers in Immunology, 2018 Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major effector of immunity, has been used in the treatment of several diseases ...
F. Castro +4 more
semanticscholar +1 more source
Interferons and Interferon Regulatory Factors in Malaria [PDF]
Mediators of Inflammation, 2014 Malaria is one of the most serious infectious diseases in humans and responsible for approximately 500 million clinical cases and 500 thousand deaths annually. Acquired adaptive immune responses control parasite replication and infection-induced pathologies.
Sin Yee Gun +3 more
openaire +4 more sources
Interferon beta in multiple sclerosis: experience in a British specialist multiple sclerosis centre [PDF]
, 2003 Background: The efficacy of interferon beta (IFN beta) is well established in relapsing-remitting multiple sclerosis (MS). However, the use of this drug in clinical practice is complex, especially because it is only partially effective, its long term ...
Dubois, B.D. +7 more
core +2 more sources
Acute respiratory viral infections: Topical issues of diagnosis, prevention and treatment in therapeutic practice [PDF]
Терапевтический архив, 2016 Objective: to assess the efficacy and safety of the medication Grippferon with loratadine for the prevention of acute respiratory viral infections (ARVI) and influenza during the epidemics.
D I Trukhan, A L Mazurov, L A Rechapova
doaj +1 more source
Modulation of Functional Activities of Chicken Heterophils by Recombinant Chicken IFN-γ [PDF]
, 2001 The objective of the present studies was to examine the in vitro effects of recombinant chicken interferon-γ (rChIFN-γ) on shape change, phagocytosis, and the oxidative/nonoxidative killing activities of day-old chicken heterophils.
B. Kaspers +12 more
core +1 more source
The Role of Atypical Ubiquitin Chains in the Regulation of the Antiviral Innate Immune Response
Frontiers in Cell and Developmental Biology, 2020 It is well established that polyubiquitin chains, in particular those linked through K48 and K63, play a key role in the regulation of the antiviral innate immune response.
Mariska van Huizen, Marjolein Kikkert
doaj +1 more source
Prediction uncertainty and optimal experimental design for learning dynamical systems [PDF]
Chaos 26, 063110 (2016), 2015 Dynamical systems are frequently used to model biological systems. When these models are fit to data it is necessary to ascertain the uncertainty in the model fit. Here we present prediction deviation, a new metric of uncertainty that determines the extent to which observed data have constrained the model's predictions.
arxiv +1 more source
Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation [PDF]
, 2016 Since the discovery of the endocannabinoid system consisting of cannabinoid receptors, endogenous ligands, and biosynthetic and metabolizing enzymes, interest has been renewed in investigating the promise of cannabinoids as therapeutic agents.
McCoy, Kathleen L.
core +4 more sources