Results 61 to 70 of about 779,562 (365)
LINE-1 derepression in senescent cells triggers interferon and inflammaging
Nature, 2018 Retrotransposable elements are deleterious at many levels, and the failure of host surveillance systems for these elements can thus have negative consequences. However, the contribution of retrotransposon activity to ageing and age-associated diseases is
M. Cecco +22 more
semanticscholar +1 more source
GIFT: Guided and Interpretable Factorization for Tensors - An Application to Large-Scale Multi-platform Cancer Analysis [PDF]
, 2018 Given multi-platform genome data with prior knowledge of functional gene sets, how can we extract interpretable latent relationships between patients and genes? More specifically, how can we devise a tensor factorization method which produces an interpretable gene factor matrix based on gene set information while maintaining the decomposition quality ...
arxiv +1 more source
Molecular Oncology, EarlyView.We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić +31 more
wiley +1 more source
Journal of Immunotoxicology, 2019 Endosulfan is a DDT-era organochlorine pesticide. Due to past and current environmental contamination, investigation of endosulfan exposure is of current importance. Acute high dose exposure precipitates neural/endocrine system damage, but the effects on
Martha Cecilia Téllez-Bañuelos +5 more
doaj +1 more source
The IFITMs Inhibit Zika Virus Replication
Cell Reports, 2016 Zika virus has emerged as a severe health threat with a rapidly expanding range. The IFITM family of restriction factors inhibits the replication of a broad range of viruses, including the closely related flaviruses West Nile virus and dengue virus. Here,
George Savidis +6 more
doaj +1 more source
Viruses, 2020 Several DNA viruses have evolved antagonists to inhibit the cyclic GMP−AMP synthase (cGAS)-stimulator of interferon genes (STING) DNA-sensing immune pathway.
Joshua B. Reus +4 more
doaj +1 more source
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis.
New England Journal of Medicine, 2010 BACKGROUND Fingolimod (FTY720), a sphingosine-1-phosphate-receptor modulator that prevents lymphocyte egress from lymph nodes, showed clinical efficacy and improvement on imaging in a phase 2 study involving patients with multiple sclerosis. METHODS In
Jeffrey A. Cohen +16 more
semanticscholar +1 more source
Interferon and Interferon Inducers in the Treatment of Malignancies [PDF]
Archives of Internal Medicine, 1970 Several laboratories have reported that viral interference, 1 interferon, 2 and interferon inducers 3,4 can inhibit the growth of oncogenic viruses in tissue culture, 5 and can alter the course of murine leukemias in animals. 6,7 It has also been shown that the double-stranded RNA, polyriboinosinic: polyribocytidylic acid (poly I:C), which among other ...
Hilton B. Levy +2 more
openaire +6 more sources
Frontiers in Microbiology, 2018 H9N2 influenza A viruses (IAV) are considered low pathogenic avian influenza viruses (LPAIV). These viruses are endemic in poultry in many countries in Asia, the Middle East and parts of Africa.
Laura Rodriguez +5 more
doaj +1 more source