Results 61 to 70 of about 1,191,146 (396)

A Systematic Review of therapeutic agents for the treatment of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) [PDF]

, 2019
Background The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) was first described in 2012 and attracted a great international attention due to multiple healthcare associated outbreaks.
Al-Ali, Anfal Y., Al-Tawfiq, Jaffar A., Momattin, Hisham   +2 more
core   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

COVID-19 and emerging viral infections: The case for interferon lambda

Journal of Experimental Medicine, 2020
The Viewpoint discusses the benefits and potential limitations of using interferon lambda (IFN-λ, a type III interferon) to prevent, limit, and treat COVID-19.
L. Prokunina-Olsson, Noémie Alphonse, Ruth E Dickenson, J. Durbin, J. Glenn, R. Hartmann, S. Kotenko, Helen M. Lazear, T. O'Brien, Charlotte Odendall, O. Onabajo, H. Piontkivska, D. Santer, N. Reich, A. Wack, I. Zanoni   +15 more
semanticscholar   +1 more source

Oral contraceptives combined with interferon β in multiple sclerosis [PDF]

, 2015
Objective: To test the effect of oral contraceptives (OCs) in combination with interferon b (IFN-b) on disease activity in patients with relapsing-remitting multiple sclerosis (RRMS).
Barletta, Valeria T., De Angelis, Floriana, De Giglio, Laura, Gallo, Valentina, Marinelli, Fabiana, Marini, Stefano, Pagano, Veronica A., Pantano, Patrizia, Piattella, Maria C., Pozzilli, Carlo, Tomassini, Valentina   +10 more
core   +3 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

LINE-1 derepression in senescent cells triggers interferon and inflammaging

Nature, 2018
Retrotransposable elements are deleterious at many levels, and the failure of host surveillance systems for these elements can thus have negative consequences. However, the contribution of retrotransposon activity to ageing and age-associated diseases is
M. Cecco, Takahiro Ito, Anna P. Petrashen, Amy E Elias, Nicholas Skvir, Steven W. Criscione, Alberto Caligiana, Alberto Caligiana, Greta Brocculi, Greta Brocculi, E. Adney, J. Boeke, O. Le, C. Beauséjour, J. Ambati, Kameshwari Ambati, M. Simon, A. Seluanov, V. Gorbunova, P. Slagboom, S. Helfand, N. Neretti, J. Sedivy   +22 more
semanticscholar   +1 more source

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

Journal of Experimental Medicine, 2020
Heterozygous missense mutations in COPA underlie constitutive interferon signaling through STING, thereby defining a novel type I interferonopathy and emphasizing the importance of the ER–Golgi axis in interferon homeostasis.
A. Lepelley, M. Martin-Niclós, M. Le Bihan, J. Marsh, C. Uggenti, G. Rice, V. Bondet, D. Duffy, Jonny Hertzog, J. Rehwinkel, S. Amselem, Siham Boulisfane-El Khalifi, M. Brennan, Edwin Carter, L. Chatenoud, S. Chhun, Aurore Coulomb l’Hermine, Marine Depp, M. Legendre, K. Mackenzie, J. Marey, C. McDougall, K. McKenzie, T. Molina, B. Neven, L. Seabra, C. Thumerelle, M. Wislez, N. Nathan, N. Manel, Y. Crow, M. Frémond   +31 more
semanticscholar   +1 more source

Interferon β-1a in relapsing multiple sclerosis: four-year extension of the European IFNβ-1a Dose-C omparison Study [PDF]

, 2004
Background: Multiple sclerosis (MS) is a chronic disease requiring long-term monitoring of treatment. Objective: To assess the four-year clinical efficacy of intramuscular (IM) IFNb-1a in patients with relapsing MS from the European IFNb-1a Dose-C ...
Achiti, J., Arbizu, T., Arnulf, I., Aubertin, P., Bamborschke, P., Belliard, S., Berger, E., Blanc, S., Brassat, D., Brochet, B., Cahagne, V., Casado, A., Cesaro, P., Chan, A., Clanet, M., Confavreux, C., Dalecky, A., Damier, P., de Keyser, Jacques, de Marco, A., Defer, G., Degos, F., Dengler, R., Dose, A., Edan, G., Engles, A., Fernandez, O., Flachenecker, A., Gayou, A., Gelderblom, H., Grunwald, F., Grupe, A., Hartung, H.P., Heesen, C., Heidenreich, F., Heinzlef, O., Hohlfeld, R., Kappos, L., Kassim, N., Koehler, A., Koerner, A., Kristoferitsch, W., Kunze, K., Kyriallis, K., Lau, G., Lecanuet, P., Lindert, A., Liu, A., Lubetzki, C., Luenemann, J., Lyon-Caen, O., Magnier, C., Martin, A, Martinez-Yelamos, A., Matzke, A., Maurer, A., Mekies, C., Menck, A., Montalban, X., Moulin, A., Nolden, A., Nos, A., Pantzaris, A., Papacostas, S., Pelletier, J., Petereit, H., Pez, D., Piette, A., Riche, G., Rieckmann, P., Romero, F., Rouanet, M., Rouant, F., Roullet, E., Rumbach, L., Sailer, 27449, Schaeffer, S., Schlederer, A., Schrieber, A., Seeldrayers, P., Senard, A., Stankoff, B., Steiner, A., Stingle, A., Storch-Hagenlocher, A., Storch-Hagenlocher, B., Suchet, L., Tamayo, J.A., Tamman, D., Thalamas, C., Vermersch, P., Vogt-Schaden, A., Vuilleman, C., Weilbach, A., Weiler, C., Windhagen, A., Zorgdrager, A., Zschenderlein, R., Zwanniken, G.   +98 more
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response

mBio, 2018
Although Toxoplasma virulence mechanisms targeting gamma interferon (IFN-γ)-induced cell-autonomous antiparasitic immunity have been extensively characterized in mice, the virulence mechanisms in humans remain uncertain, partly because cell-autonomous ...
Hironori Bando, Youngae Lee, Naoya Sakaguchi, Ariel Pradipta, Ji Su Ma, Shun Tanaka, Yihong Cai, Jianfa Liu, Jilong Shen, Yoshifumi Nishikawa, Miwa Sasai, Masahiro Yamamoto   +11 more
doaj   +1 more source