Results 81 to 90 of about 779,562 (365)

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

Molecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song, Zhe Wang, Guangji Zhang, Jiangxue Hou, Kaiqi Liu, Shuning Wei, Yan Li, Chunlin Zhou, Dong Lin, Min Wang, Hui Wei, Jianxiang Wang, Tao Cheng, Yingchang Mi   +13 more
wiley   +1 more source

An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection

Journal of Experimental Medicine, 1993
Tuberculosis, a major health problem in developing countries, has reemerged in recent years in many industrialized countries. The increased susceptibility of immunocompromised individuals to tuberculosis, and many experimental studies indicate that T ...
J. Flynn, J. Chan, Karla J. Triebold, D. Dalton, T. A. Stewart, B. Bloom   +5 more
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Gene expression analysis reveals a strong signature of an interferon induced pathway in childhood lymphoblastic leukemia as well as in breast and ovarian cancer [PDF]

Oncogene vol 24 p 6367 (2005), 2005
On the basis of epidemiological studies, infection was suggested to play a role in the etiology of human cancer. While for some cancers such a role was indeed demonstrated, there is no direct biological support for the role of viral pathogens in the pathogenesis of childhood leukemia. Using a novel bioinformatic tool, that alternates between clustering
arxiv  

The use of restricted mean survival time to estimate treatment effect under model misspecification, a simulation study [PDF]

arXiv, 2023
The use of the non-parametric Restricted Mean Survival Time endpoint (RMST) has grown in popularity as trialists look to analyse time-to-event outcomes without the restrictions of the proportional hazards assumption. In this paper, we evaluate the power and type I error rate of the parametric and non-parametric RMST estimators when treatment effect is ...
arxiv  

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Cytokine Research in Depression: Principles, Challenges, and Open Questions

Frontiers in Psychiatry, 2019
Cytokines have been implicated in the pathology of depression. Currently, the evidence is based on cross-sectional studies and meta-analytic research comparing blood concentrations of T helper type 1 (TH1), T helper type 2 (TH2), pro-inflammatory or anti-
Hubertus Himmerich, Hubertus Himmerich, Olivia Patsalos, Nicole Lichtblau, Mohammad A. A. Ibrahim, Bethan Dalton   +5 more
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood

Journal of Experimental Medicine, 2003
Systemic lupus erythematosus (SLE) is a prototype systemic autoimmune disease characterized by flares of high morbidity. Using oligonucleotide microarrays, we now show that active SLE can be distinguished by a remarkably homogeneous gene expression ...
Lynda Bennett, A. Palucka, E. Arce, E. Arce, Victoria Cantrell, Victoria Cantrell, J. Borvák, J. Banchereau, V. Pascual, V. Pascual   +9 more
semanticscholar   +1 more source

The Host Restriction Factor Interferon-Inducible Transmembrane Protein 3 Inhibits Vaccinia Virus Infection

Frontiers in Immunology, 2018
Interferons (IFNs) establish dynamic host defense mechanisms by inducing various IFN-stimulated genes that encodes many antiviral innate immune effectors. IFN-inducible transmembrane (IFITM) proteins have been identified as intrinsic antiviral effectors,
Chang Li, Chang Li, Chang Li, Chang Li, Shouwen Du, Shouwen Du, Mingyao Tian, Yuhang Wang, Jieying Bai, Peng Tan, Wei Liu, Ronglan Yin, Maopeng Wang, Ying Jiang, Yi Li, Na Zhu, Yilong Zhu, Tiyuan Li, Shipin Wu, Ningyi Jin, Ningyi Jin, Ningyi Jin, Fuchu He   +22 more
doaj   +1 more source