Results 141 to 150 of about 179,738 (255)

Cockroach‐Derived Leucokinin VIII Peptide Accelerates Diabetic Skin Wound Healing by Enhancing Keratinocyte Filopodia Formation

Advanced Science, EarlyView.
This study identifies the cockroach‐derived peptide leucokinin VIII as a potent accelerator of diabetic wound healing. By activating the FAK‐ACTG1 axis, the peptide drives keratinocyte migration and filopodia formation. Delivered via a developed PLGA‐PEG‐PLGA thermosensitive hydrogel for sustained release, this approach significantly hastens wound ...
Zhengshan Qin, Jinchuan Wu, Xiehua Xiao, Xirui Wang, Nianhui Ding, Xin Zhao, Lu Ma, Jie Li, Lunkun Ma, Cehua Ou, Ning Ma, Jianguo Feng   +11 more
wiley   +1 more source

Tracheobronchial infectious diseases in adult-onset immunodeficiency with anti-interferon-gamma autoantibodies. [PDF]

BMC Infect Dis
Liang X, Ma N, Liang S, Huang X, Liang H, Wu S, Ning Y, Pang H, Zhang Z, Chen N, Hong L, He Z.   +11 more
europepmc   +1 more source

One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy

Advanced Science, EarlyView.
This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu, Ben Huang, Lingyan Wang, Qiang Guo, Cuiping Jiang, Ruicheng Qi, Shuyao Wang, Lin‐Tai Da, Wenjie Peng   +8 more
wiley   +1 more source

Pustular reaction in adult-onset immunodeficiency due to anti-interferon-gamma autoantibodies. [PDF]

Front Immunol
Julanon N, Danpanichkul P, Choonhakarn C, Chaowattanapanit S, Anunnatsiri S, Chetchotisakd P, Kiratikanon S, Rujiwetpongstorn R, Tovanabutra N, Chiewchanvit S, Chaiwarith R, Phinyo P, Chuamanochan M.   +12 more
europepmc   +1 more source

CRISPR/Cas9‐Based Vanadium MXene‐Free Radical Spatiotemporally Controlled Nanoreactor for Photothermal‐Induced Multi‐Effect Synergistic Antitumor Therapy

Advanced Science, EarlyView.
In this study, a MXene‐based V4C3 nanoplatform, VARH, was constructed, which achieved a photothermal conversion efficiency of 44.21% in the NIR‐II window. This platform integrated photothermal therapy, chemodynamic therapy, and thermodynamic therapy with CRISPR/Cas9‐mediated heat shock protein 90 knock‐out technology.
Zi‐Jian Huang, Feng‐Ming Li, Yi‐Fan Tu, Ke‐Ke Feng, Cheng‐Lei Li, Shi‐Cheng Tian, Yong‐Shan Hu, Jing‐Wei Shao, Zhen‐Hua Liu   +8 more
wiley   +1 more source

Prevention of secondary infections by interferon-gamma in ICU-acquired sustained immune suppression in France: study protocol of the PLATINIUM randomised trial. [PDF]

BMJ Open
Hernandez Padilla AC, Daix T, Hotchkiss RS, Monneret G, Tadie JM, Jeannet R, Plateker O, Vaidie J, Durand-Zaleski I, Magne J, Giraudeau B, François B.   +11 more
europepmc   +1 more source

Interferon: Gamma winners [PDF]

Nature, 1981
openaire   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Cutaneous Opportunistic Mycobacterial and Fungal Infections in Adult-Onset Immunodeficiency Due to Anti-Interferon-Gamma Autoantibodies-Decoding Skin Involvement Patterns. [PDF]

Open Forum Infect Dis
Rujiwetpongstorn R, Pinyo P, Prinyaroj N, Chaiwarith R, Kiratikanon S, Tovanabutra N, Chiewchanvit S, Choonhakarn C, Chaowattanapanit S, Chuamanochan M, Meesing A.   +10 more
europepmc   +1 more source

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source