Results 121 to 130 of about 854,306 (293)

Diagnostic Value of Interferon-Gamma Assay in Tuberculosis Pericardial Effusions: Study on A Cohort of Iranian Patients

Acta Medica Iranica, 2013
Tuberculosis pericarditis as a potentially fatal complication of tuberculosis requires effective diagnosis and treatment. We evaluated the efficacy of interferon-gamma (IFN-gamma) and adenosine deaminase (ADA) for diagnosing tuberculosis pericarditis in ...
Hamid Emadi Koochak, Setareh Davoudi, Abbas Salehi Omran, Reyhaneh Mohsenipour, Keveh Hajifathalian, Behtash Saeidi, Ali Akbar Amirzargar, Maryam Sotoudeh, Soroush Seifirad   +8 more
doaj  

Human macrophages degrade tryptophan upon induction by interferon-gamma

, 2010
Human peripheral blood mononuclear cells, monocytes-macrophages and T-cells were stimulated with human recombinant interferon-gamma, interferon-alpha and phytohemagglutinin.
Werner, Ernst R., Szabo, Gyongyi, Bitterlich, Gabriele, Fuchs, Dietmar, Reibnegger, Gilbert, Dierich, Manfred P., Wachter, Helmut, Hausen, Arno   +7 more
core   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

The influence of genetic variants of IL-6 (-174 G/C) and INFγ (+ 874 A/T) and their impact on anemic Sudanese children with kidney failure

BMC Research Notes
Objectives To investigate the influence of genetic variants IL-6 (-174 G/C) and interferon-gamma (IFNγ) (+ 874 A/T) on beta-globin gene expression, inflammation markers such as C-reactive protein (CRP), and their diagnostic impact on anemic Sudanese ...
Abier Abdelaziz Makkawi Abdelrahman Makkawi, Salah Eldin GumaaElzaki GumaaElzaki, Nahla Allam Allam, Nadia Madani Mohammed Ahmed Mohammed, Nazik Elmalaika Obaid Seid Ahmed Husain Husain   +4 more
doaj   +1 more source

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

Evaluation of Interferon-Gamma, Vitamin E, and Electrolytes (Sodium, Potassium, Chloride) Levels as Potential Biomarkers in Iraqi Breast Cancer Women

Proceedings of the International Conference on Applied Innovations in IT
The primary objective of this study is to evaluate the potential of interferon-gamma, vitamin E, and electrolyte levels (sodium, potassium, and chloride) as biomarkers for breast cancer diagnosis.
Muqdad Khamis Abd, Abdulsalam Tawfeeq Salih Alsamarai, Ahmed Zuhair Alsammarraie   +2 more
doaj   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Pulmonary catabolism of interferon-gamma evaluated by lung perfusion of both normal and smoke-exposed rats

, 1995
The role of the lungs in the catabolism of rat recombinant interferon-gamma, either in normal rats or in rats subjected to an acute cigarette smoking episode, was evaluated using an isolated and perfused lung preparation.
Aldinucci, C., CARLO ALDINUCCI, Pessina, G. P., LUANA PAULESU, Ricci, L., Luzzi, E., Bocci, V., Corradeschi, F., FAUSTO CORRADESCHI, GIAN PAOLO PESSINA, ENRICO LUZZI, VELIO BOCCI   +11 more
core   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Multi‐Tissue Crosstalk Regulating Meniscus Healing Under Inflammation and Physiological Loading

Advanced Science, EarlyView.
Using a novel Meniscus‐on‐a‐chip (MoC) model integrated with a meniscus‐specific bioreactor, this study investigated the roles of multi‐tissue crosstalk that regulates injury, healing, and degeneration of the meniscus injury under inflammation and pathophysiological loading.
Hun Jin Jeong, Elen Zhu, Min Seo Kang, Ming Wang, Sam Comito, Chang H. Lee   +5 more
wiley   +1 more source