Results 141 to 150 of about 854,306 (293)

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Long-acting pegylated interferon gamma sensitizes AML cells to killing by donor T cells. [PDF]

Blood Adv
Basu V, Mannino G, Mpofu L, Struthers H, Carlson SJ, Cox GN, Spencer DH, Rettig MP, Christopher MJ.   +8 more
europepmc   +1 more source

Disentangling Heterogeneous Molecular Networks for Multi‐Omics‐Driven Cancer Driver Discovery

Advanced Science, EarlyView.
DRIVE integrates PPI topology and pan‐cancer multi‐omics profiles through dual‐view graph disentanglement, contrastive representation learning, and joint optimization. Across six PPI networks, DRIVE outperforms ten baselines and remains robust to structural and annotation perturbations.
Xinjing Gong, Ji Li, Mu Su, Peishen Yu, Te Ma, Ruiyang Zhai, Chenye Zhang, Mengyan Zhang, Yan Zhang   +8 more
wiley   +1 more source

Immunometabolic and RAAS determinants of circulating interferon gamma in an HIV and TB Zambian cohort. [PDF]

Discov Public Health
Sidambi D, Chisompola D, Lwindi P, Kaango A, Hamooya BM, Povia JP, Masenga SK.   +6 more
europepmc   +1 more source

Interferon-gamma release assays (IGRAs) - blood tests for TB infection [PDF]

Interferon-Gamma Release Assays (IGRAs) are whole-blood tests that can aid in diagnosing Mycobacterium tuberculosis infection. They do not help differentiate latent tuberculosis infection (LTBI) from tuberculosis disease.

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An ATP7A‐Mediated Endogenous Regulation Bio‐Clay Enzyme Enables Self‐Amplified Copper Accumulation for Immunogenic Pyrop

Advanced Science, EarlyView.
A self‐amplifying bio‐clay nanozyme (Bio‐Clayzyme) disrupts tumor metabolic homeostasis through endogenous copper transporter ATPase (ATP7A) downregulation, enhancing cascade catalysis and triggering immunogenic pyroptosis for effective tumor immunotherapy.
Weimin Xie, Yan Li, Guangyao Li, Ying Chen, Huaming Yang   +4 more
wiley   +1 more source

Quantitative measurement of anti-interferon-gamma autoantibodies for routine laboratory implementation. [PDF]

iScience
Cuong TH, Manbenmad V, Srisai P, Hongsa C, Wisedsuk T, Krungmee A, Surapaitoon A, Nawawishkarun P, Chantarasuk Y, Phanthanawiboon S, Nithichanon A.   +10 more
europepmc   +1 more source

Modulation of Fc gamma receptors on human mononuclear phagocytes by dexamethasone and interferon-gamma

, 1991
Human monocytes and macrophages bear three distinct classes of cell surface receptors for the Fc portion of IgG, Fc$\sb{\gamma}$RI (CD64), Fc$\sb{\gamma}$RII (CD32), and Fc$\sb{\gamma}$RIII (CD16).
Comber, Paul Gerald
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