Results 151 to 160 of about 854,306 (293)

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

Comparison of Tuberculin Skin Test and Interferon-Gamma Release Assay for Latent Tuberculosis Screening in Healthcare Workers. [PDF]

Cureus
Alrajhi K, Algarni A, Abulola W, Alhadad A, Fallatah S, Alrajhi M, Ghasib A, Fan H, Vali Y.   +8 more
europepmc   +1 more source

RECEIVING THE MUTANT VARIANTS OF THE MAN'S GAMMA-INTERFERON AND INVESTIGATION OF ITS PROPERTIES

, 1995
The object of investigation: the gamma-interferon of the man. The purpose of the work: obtaining the modified variants of the man's gamma-interferon with the improved medico-biological properties, using the method of the oligonucleotid-directed ...
Smirnova, Olga Yurievna
core  

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Serum hepcidin measurement is related to clinical parameters and interferon-gamma in anemia of inflammation. [PDF]

Einstein (Sao Paulo)
Maciel RO, Mendonça PDS, Mota AGM, Wong DVT, Lima Júnior RCP, Pinheiro RF, Magalhães SMM.   +6 more
europepmc   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

Single-Cell RNA Sequencing Revealed the Role of Interferon-Gamma Related Genes in Primary Sjögren's Syndrome. [PDF]

J Cell Mol Med
Shi L, Wei TC, Zhang J.
europepmc   +1 more source

Long‐Term Human Skin Platform for Modeling Chronic Inflammation, Environmental Stress, and Therapeutic Intervention

Advanced Science, EarlyView.
An advanced, long‐term human skin platform maintains native skin structure and key tissue functions for up to four weeks. The platform models chronic inflammation, aging‐related skin changes, and UVB damage, enabling drug and topical interventions—including anti‐inflammatory therapy, senolytic treatment, and sunscreen—to be evaluated in intact human ...
Purnendu Kumar Sharma, Evelien Schaafsma, Elysia Anderson, Jocelyn Chiari, Paige Thompson, Erin Galt, Sunghoon Lee, Jason Holsapple, Sai Hein, Bailey L. Coates, Jade Michaud, Sabrina Zuccaro, Lia Kent, Chris Hinojosa, Kyung‐Jin Jang   +14 more
wiley   +1 more source

Interferon-gamma autoantibodies in patients with infectious uveitis: a pilot case-control study. [PDF]

BMC Infect Dis
Opasatian A, Tayapiwatana C, Thongkum W, Yasamut U, Pathanapitoon K.   +4 more
europepmc   +1 more source

The effect of interferon gamma on conventional fractionated radiation-induced damage and fibrosis in the pelvic tissue of rabbits

, 2016
Yunyi Yang, Zi Liu, Juan Wang, Yanlan Chai, Jin Su, Fan Shi, Jiquan Wang, Shao Min Che Department of Radiation Oncology, The First Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an, Shanxi, People’s Republic of ...
Liu Z, Yang Y, Che SM, Shi F, Su J, Wang J, Chai Y   +6 more
core