Results 201 to 210 of about 128,935 (252)

Interferon signaling pathways in health and disease. [PDF]

Mol Biomed
Wen C, Lan Q, Wang Y, Ni Y, Wong AST, Liu D.   +5 more
europepmc   +1 more source

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The interferon gamma (IFN-γ) receptor: a paradigm for the multichain cytokine receptor

Cytokine and Growth Factor Reviews, 1997
With the purification and cloning of the interferon gamma (IFN-gamma) receptor chains the mechanism of IFN-gamma action and the resultant signal transduction events were delineated in remarkable detail. The interferon gamma (IFN-gamma) receptor complex consists of two chains: IFN-gammaR1, the ligand-binding chain, and IFN-gammaR2, the accessory chain ...
Lara S Izotova, Jeffry R Cook, Gianni Garotta   +2 more
exaly   +3 more sources

The Molecular Cell Biology of Interferon-gamma and its Receptor

Annual Review of Immunology, 1993
The last ten years have seen an explosive growth in our understanding of IFN gamma. The cloning of the cDNAs for IFN gamma and its receptor have made available large amounts of highly purified recombinant IFN gamma and soluble IFN gamma receptor. In addition, highly specific neutralizing monoclonal antibodies have been generated to both of these ...
Robert D Schreiber
exaly   +3 more sources

Enrichment and initial characterization of the solubilized receptor for mouse gamma interferon

Biochemical and Biophysical Research Communications, 1988
The work reported here constitutes a first step in characterizing the receptor for mouse gamma interferon at the biochemical level. The myelomonocytic cell line, WEHI-3, was the source of starting material. Iodinated recombinant mouse gamma interferon incubated with WEHI-3 cells, as well as membranes prepared from them, bound specifically to a single ...
Stephen W Russell, Paul P Trotta, Mitali Basu   +2 more
exaly   +3 more sources

The role of interferon-gamma and its receptors in gastrointestinal cancers

Pathology - Research and Practice, 2023
Gastrointestinal malignancies are the most prevalent type of cancer around the world. Even though numerous studies have evaluated gastrointestinal malignancies, the actual underlying mechanism is still unknown. These tumors have a poor prognosis and are frequently discovered at an advanced stage.
Zahra Mozooni, Nafiseh Golestani, Leyla Bahadorizadeh, Reyhaneh Yarmohammadi, Mohammad Jabalameli, Bahareh Shateri Amiri   +5 more
openaire   +2 more sources

The biology and biochemistry of interferon-gamma and its receptor

Gastroenterologia Japonica, 1993
Interferon-gamma (IFN gamma) is an important immunomodulatory cytokine produced by activated T cells and NK cells that plays a pivotal role in promoting host defense. IFN gamma is distinguished from IFN alpha and IFN beta by its ability to regulate a number of immune functions.
R D, Schreiber, M A, Farrar
openaire   +2 more sources

Interferon-Gamma Receptors in HIV-1 Infection

AIDS Research and Human Retroviruses, 2008
We studied in vitro production of interferon-gamma and expression of interferon-gamma receptors (R1 and R2) by the peripheral blood mononuclear cells of 24 HIV-1-infected patients and 12 healthy volunteers. Interferon-gamma production was lower in HIV-1-infected patients compared with healthy volunteers (p < 0.05), and it further declined in patients ...
Janak, Koirala, Alys, Adamski, Lori, Koch, Danielle, Stueber, Mohammed, El-Azizi, Nancy M, Khardori, Mahmood, Ghassemi, Richard M, Novak   +7 more
openaire   +2 more sources

Characterization of interferon gamma receptors on osteoclasts: Effect of interferon gamma on osteoclastic superoxide generation

Journal of Cellular Biochemistry, 2002
AbstractOsteoclasts are the primary cells responsible for bone resorption. Osteoclast formation and bone resorption activities involve processes tightly controlled by a network of cytokines. The presence of interferon gamma (IFN‐γ) receptors on osteoclasts is a necessary prerequisite for IFN‐γ to directly affect osteoclastic activity.
Su, Yang, Prema, Madyastha, William, Ries, Lyndon L, Key   +3 more
openaire   +2 more sources

High Levels of Interferon Gamma in the Plasma of Children With Complete Interferon Gamma Receptor Deficiency

Pediatrics, 2001
We have found that children with complete interferon gamma (IFNγ) receptor deficiency, unlike patients with other genetic defects predisposing them to mycobacterial diseases, have very high levels of IFNγ in their plasma. This unexpected observation provides a simple and accurate diagnostic method for complete IFNγ receptor deficiency in children with ...
C, Fieschi, S, Dupuis, C, Picard, C I, Smith, S M, Holland, J L, Casanova   +5 more
openaire   +2 more sources