Results 221 to 230 of about 128,935 (252)

[Characterization of the receptor for murine gamma interferon].

Giornale di batteriologia, virologia ed immunologia, 1987
Rabbits immunized with murine cells EL-4 expressing high number of interferon-gamma (IFN-gamma) receptors produce antibodies which inhibit the specific binding of murine 125I-IFN-gamma to the surface of target cells. Moreover to define the M.W. of the IFN-gamma receptor we have performed cross-linking experiments using 125I-IFN-gamma.
F, Cofano, A, Fassio, L, Fava, G, Cavallo, S, Landolfo   +4 more
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Soluble interferon-γ receptors encoded by poxviruses

Comparative Immunology, Microbiology and Infectious Diseases, 1996
Poxviruses encode a broad range of proteins that counteract the formidable attack of the immune response initiated in the host after infection, among which are proteins that mimic the extracellular binding domain of host cytokine receptors and are secreted from virus-infected cells.
A, Alcamí, G L, Smith
openaire   +2 more sources

The interferon gamma receptor.

Lymphokine research, 1988
Interferon-gamma (IFN gamma) can regulate in vitro and in vivo a number of functions on a variety of cell types including some with no known immune functions. Recent work has indicated that IFN gamma exerts its effects upon interaction with a specific receptor on the cell surface. An IFN gamma receptor has been detected in a large variety of cell types
openaire   +1 more source

[Analysis of the gamma interferon receptor in mice].

Giornale di batteriologia, virologia ed immunologia, 1986
Natural murine interferon-gamma (IFN-gamma) produced by the T lymphoma, L12R4, stimulated with phorbol myristic acetate was purified by anti-murine IFN-gamma immunoadsorbent and labeled with 125I to study its binding to receptors of mouse cells. By adding increasing concentrations of unlabeled natural murine IFN-gamma in competition binding assays we ...
F, Cofano, A, Fassio, G, Cavallo, S, Landolfo   +3 more
openaire   +1 more source

Distribution of interferon‐γ receptor in human tissues

European Journal of Immunology, 1992
AbstractInterferon‐γ (IFN‐γ) is produced by activated T lymphocytes and plays a regulatory role in immune responses. The nature and location of cells that express the IFN‐γ receptor (R) and respond to this lymphokine are not well documented. The distribution of human IFN‐γ‐R (HuIFN‐γ‐R) was, therefore, investigated in situ by immunohistochemistry ...
VALENTE, Guido, OZMEN L, NOVELLI F, GEUNA M, PALESTRO G, FORNI G, GAROTTA G.   +6 more
openaire   +3 more sources

The gene for the ligand binding chain of the human interferon gamma receptor

Immunogenetics, 1997
In order to characterize the gene encoding the ligand binding (1(st); alpha) chain of the human IFN-gamma receptor, two overlapping cosmid clones were analyzed. The gene spans over 25 kilobases (kb) of the genomic DNA and has seven exons. The extracellular domain is encoded by exons 1 to 5 and by part of exon 6. The transmembrane region is also encoded
Merlin, G., van der Leede, Bas-Jan Martin, McKune, Keith, Knezevic, Nikola, Bannwarth, Wilhelm, Romquin, Nicole, Viegas-Pequignot, Evani, Kiefer, Hansruedi, Aguet, M., Dembic, Zlatko   +9 more
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The Interferon-γ Receptor: A Comparison with Other Cytokine Receptors

Journal of Interferon Research, 1990
During the past few years, identification of cytokine receptors has become a major goal in cytokine research. A great deal has been learned from the plethora of receptor structures that have been elucidated recently. Although, evidently, the complexity of the cytokine network extends to the signaling pathways involved, some of these pathways have now ...
openaire   +3 more sources

Photoaffinity labeling of an interferon-gamma receptor on the surface of cultured fibroblasts

Biochemical and Biophysical Research Communications, 1984
Highly purified native and recombinant 125I-interferon-gamma was acylated with the photoreactive cross-linking reagent, N-succinimidyl-6(4'-azido-2'-nitrophenylamino) hexanoate. Derivatized interferon covalently labeled a cell surface component with an aggregate Mr = 230,000 +/- 7,000 (n = 7).
P, Anderson, C, Nagler
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Signal Transduction through Interferon–Gamma Receptor on Human Eosinophils

International Archives of Allergy and Immunology, 1999
<b>Background: </b>We reported on the constitutive interferon–γ receptor (IFN–γR) expression on eosinophils. But signal transduction through IFN–γR on eosinophils remains to be elucidated. In this study, we examined the involvement of the Jak/Stat pathway in the signaling of eosinophils after IFN–γR conjugation by the ligand binding.
K, Ochiai, C, Ishihara, H, Tomioka
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Structural elements required for receptor recognition of human interferon-gamma

Pharmacology & Therapeutics, 1994
Interferon (IFN)-gamma is a central factor in numerous immune responses. Recently the three-dimensional structure of human and rabbit IFN-gamma has been elucidated. This review attempts to bring together the structure and function information into a working model of IFN-gamma: receptor interaction. Based on mutagenesis studies, and corroborated by work
D L, Lundell, S K, Narula
openaire   +2 more sources