Results 201 to 210 of about 50,514 (354)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Interferon signaling and STING pathway in head and neck cancers: unlocking immune secrets and therapeutic frontiers. [PDF]

Cancer Cell Int
Zolfaghari K, Yazdi M, Mohammadioun S, Tajafrooz F, Malekfarnood H, Saleki K, Rezaei N.   +6 more
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Ferroptosis triggers anti-tumor immunity via promoting chaperone-mediated autophagic degradation of SHP2. [PDF]

Redox Biol
Zhu J, Li X, Chen W, Zuo Z, Gong Q, Hu J, Huang K, Liu W, Gu Y, Xu Q, Guo W.   +10 more
europepmc   +1 more source

Autoantibodies against cerebral gray matter in patients with insulin dependant diabetes mellitus [PDF]

, 1990
Kömpf, D., Schaper, J., Schuhose, C., Scriba, Peter Christian, Stöcker, W., Vieregge, P.   +5 more
core  

Autocrine cell suicide in a Burkitt lymphoma cell line (Daudi) induced by interferon α: involvement of tumor necrosis factor as ligand for the CD95 receptor [PDF]

, 2001
Heinz Gisslinger, Razelle Kurzrock, Bettina Gisslinger, Shuwei Jiang, Shuren Li, Irene Virgolini, W. Woloszczuk, Michael Andreeff, Moshe Talpaz   +8 more
openalex   +1 more source

Single‐Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma

Advanced Science, EarlyView.
KYNA regulates the tumor immune microenvironment in glioblastoma. KYNA reprograms the balance between T cell exhaustion and activation to suppress glioblastoma progression through inhibiting exhaustion‐associated markers (such as PD‐1, LAG3, and TOX) and enhancing immune activation and cytotoxicity markers including granzymes GZMA and GZMB.
Di Chen, Liming Sun, Jiajun Chen, Zi Ye, Xuqiang Zhu, Hongjiang Li, Lixin Wu, Guohua Zhao, Qinghao Zhang, Guangyi Jiang, Yuchen Ji, Yake Xue, Hongwei Li, Ruokun Chen, Hongwei Zheng, Rong Zeng, Dongming Yan, Yong Zhang, Xueyuan Li, Jing Yan   +19 more
wiley   +1 more source

Book Review: Interferons and Interferon Inducers [PDF]

Proceedings of the Royal Society of Medicine, 1973
openaire   +1 more source

PGE1 Suppresses the Expression of M2 Markers on Macrophages Through Prostaglandin Receptors. [PDF]

Cells
Tsuchiya H, Hanaki T, Yoshida J, Obora M, Fujiwara Y, Nanba D.   +5 more
europepmc   +1 more source

A fluorescent lectin-agarose bead immunoassay for pancreatic autoantigen involved in Crohn´s disease [PDF]

, 1990
Horbach, E., Kaiser, D., Otte, M., Rögener, W., Scriba, Peter Christian, Stöcker, W.   +5 more
core