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The Interferon-Inducible GTPases

Annual Review of Cell and Developmental Biology, 2006
Mammalian cells respond to interferons (IFNs) secreted during infection by the transcriptional upregulation of as many as a thousand genes. This remarkable transition prepares cells and organisms for resistance to infection, and many IFN-regulated gene products are players in well-understood resistance programs.
Martens, Sascha, Howard, Jonathan
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Interferon-Induced Sarcoidosis

Journal of Computer Assisted Tomography, 2003
Interferons have been used as therapy of both malignant and nonmalignant diseases and commonly in the treatment of hepatitis C virus infection. Although the most commonly encountered side effects of interferon therapy include nonspecific constitutional symptoms, pulmonary involvement is rare.
Ami N, Rubinowitz   +2 more
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Interferon-Induced Sarcoidosis

JCR: Journal of Clinical Rheumatology, 2006
Rheumatologists are increasingly asked to see patients with hepatitis C who exhibit a variety of clinical and serologic features that mimic systemic rheumatic disease. Treatment with interferons, now the standard of care, can precipitate a variety of inflammatory conditions, including sarcoidosis.
Mittie K, Doyle   +2 more
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Interferons and Interferon Inducers

JAMA: The Journal of the American Medical Association, 1973
The fascinating field of the interferons is thoroughly reviewed and brought up to date in this fine volume in the series, Frontiers of Biology . Though a multiauthored presentation, it contains surprisingly little redundancy, a compliment to the editor, N. B. Finter.
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The Effect of Interferon and Interferon Inducers on Avian Influenza

Journal of Infectious Diseases, 1971
The effects of interferon and interferon inducers on infection due to avian influenza virus in six-week-old chickens was studied after intratracheal administration of virus. Influenza A, avian type 5 T/ONT/6828 was shown to be as sensitive as bovine vesicular stomatitis virus to the antiviral activity of chicken interferon, polyriboinosinic ...
J, Portnoy, T C, Merigan
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Interferons and interferon-induced antiviral proteins in the testis

Journal of Reproductive Immunology, 1998
Despite the dramatic development of sexually transmissible diseases, the antiviral capabilities of testicular cells have not yet been explored. Interferons (IFNs) are proteins playing a key role in the antiviral defense system, their activity being mediated by several IFN-induced proteins.
N, Dejucq, M O, Liénard, B, Jégou
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Interferons and Interferon Inducers

Drugs, 1982
Interferons are broadly antiviral, naturally occurring substances, whose exact mechanism of action on virus infections is unknown. Major limitations on the quantities of interferon available for clinical trials have inhibited its development as a therapeutic agent. The variable nature of virus infections in certain patient populations has also produced
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