Results 161 to 170 of about 5,868,061 (290)

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Interferon Regulatory Factor 9 [PDF]

, 2020
openaire   +1 more source

Interferon-alpha reduces human hippocampal neurogenesis and increases apoptosis via activation of distinct STAT1-dependent mechanisms

, 2018
BACKGROUND: In humans, interferon-a treatment for chronic viral hepatitis is a well-recognized clinical model for inflammation-induced depression, but the molecular mechanisms underlying these effects are not clear.
Sandrine Thuret (119458), ImmunoPsychiatry Consortium MRC (16249067), Neil Harrison (4462381), Alessandra Borsini (8670870), Annamaria Cattaneo (3859357), Carmine M Pariante (13380282), Patricia A Zunszain (16249070), Chiara Malpighi (16249064)   +7 more
core  

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Interferon Regulatory Factor 1 [PDF]

, 2020
openaire   +1 more source

PRELIMINARY INVESTIGATION ON CRUCIAN CARP INTERFERON REGULATORY FACTOR 1 ROLE IN FISH INTERFERON SYSTEM

, 2008
More attention has been paid to fish interferon (IFN) system since it played a key role in fish innate immune system. The interferon regulatory factor (IRF) family comprises transcription factors that regulate the expression of interferon and IFN ...
Shi Jun, Shi Yan (syan800@yahoo.com.cn), Zhao Zhe, Zhang Qi-Ya, Zhang Yi-Bing, Gui Jian-Fang (jfgui@ihb.ac.cn), Chinese Acad Sci, State Key Lab Freshwater Ecol and Biotechnol, Inst Hydrobiol, Wuhan 430072, Peoples R China, Zhu Xin-Ping, Shi Yan   +8 more
core  

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Repression of interferon regulatory factor-4 (IRF4) hyperactivation restricts murine lupus

Signal Transduction and Targeted Therapy, 2023
Shijun He, Huihua Ding, Li Chen, Yiwei Shen, Yuting Liu, Fenghua Zhu, Xiaoqian Yang, Nan Shen, Zemin Lin, Jianping Zuo   +9 more
doaj   +1 more source

Interferon regulatory factor 1: a key transcriptional node orchestrating macrophage polarization: mechanisms and therapeutic potential. [PDF]

Front Immunol
Cao S, Feng S, Gao Y, Sun Z, Bai S, Su X.   +5 more
europepmc   +1 more source

Interferon Regulatory Factor 5 [PDF]

, 2020
openaire   +1 more source