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IRF7: Role and Regulation in Immunity and Autoimmunity
Frontiers in Immunology, 2023 Interferon regulatory factor (IRF) 7 was originally identified as master transcriptional factor that produced IFN-I and regulated innate immune response, subsequent studies have revealed that IRF7 performs a multifaceted and versatile functions in ...
Qiangguo Gao
exaly +3 more sources
Frontiers in Genetics, 2018 During mammalian viral infections, interferon regulatory factor 7 (IRF7) partners with IRF3 to regulate the type I interferon response. In chickens, however, it is still unclear how IRF7 functions in the host innate immune response, especially given that
Huaijun Zhou, Tae Hyun Kim
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Cell ReportsSummary: Interferon regulatory factor 7 (IRF7) is a master transcriptional regulator of innate immunity. IRF7 binds as a homodimer, or heterodimer with IRF3, to promoters of type I interferons (IFN-Is) to drive their expression, which activates ...
Mathieu Quesnel-Vallières +2 more
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IRF7-deficient MDCK cell based on CRISPR/Cas9 technology for enhancing influenza virus replication and improving vaccine production [PDF]
PeerJ, 2022 The influenza virus is a cause of seasonal epidemic disease and enormous economic injury. The best way to control influenza outbreaks is through vaccination.
Oraphan Mayuramart +8 more
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OncoImmunology, 2021 Although pharmacological stimulation of TLRs has anti-tumor effects, it has not been determined whether endogenous stimulation of TLRs can lead to tumor rejection.
Diana Shah +10 more
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Role of interferon regulatory factor 7 in corneal endothelial cells after HSV-1 infection
Scientific Reports, 2021 Viral infections of the cornea including herpes simplex virus 1 (HSV-1) cause visual morbidity, and the corneal endothelial cell damage leads to significant visual impairment.
Fumie Ohtani +5 more
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Enterovirus D68 VP3 Targets the Interferon Regulatory Factor 7 To Inhibit Type I Interferon Response
Microbiology Spectrum, 2023 Enterovirus D68 (EV-D68) is a globally emerging pathogen causing severe respiratory illnesses mainly in children. The protease from EV-D68 could impair type I interferon (IFN-I) production.
Jun Kang +8 more
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Vaccines, 2020 Duck Tembusu virus (DTMUV) has recently appeared in ducks in China and the key cellular determiners for DTMUV replication in host cells remain unknown.
Zhiqiang Hu +22 more
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Functional Analysis of Chicken IRF7 in Response to dsRNA Analog Poly(I:C) by Integrating Overexpression and Knockdown. [PDF]
PLoS ONE, 2015 In order to develop novel strategies to protect against increasingly virulent bird-linked pathogens, a better understanding of the avian antiviral response mechanism is essential. Type I interferons (IFNs) are recognized as the first line of defense in a
Tae Hyun Kim, Huaijun Zhou
doaj +1 more source
OncoImmunology, 2018 Macrophages exhibit phenotypic heterogeneity under both physiological and pathological conditions. Applications targeting M2-like tumor-associated macrophages (TAMs) improve outcome in solid tumors.
Xiao Yang +8 more
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