Results 41 to 50 of about 24,207 (226)

The neddylation of mammalian IRF7 prevents its dimerization with IRF5.

, 2021
(A-C) After BMDMs were cultured from Nedd8F/F and Nedd8ΔMye mice or 24 h after HEK-293T cells were transfected with the indicated mammalian expression vectors, the cells were pretreated with or without MLN4924 (0.5 μM, 3 h), followed by SeV infection for
Chunmei Hou (291664), Qingyang Wang (460264), Qianqian Cheng (4872292), Tao Zou (662198), Xiqin Yang (4623160), Jia He (89641), Chunxiao Niu (11419937), Zhenjie Ye (11419940), Jie Dong (12143), Xiaoyao Feng (11419928), Daohai Cheng (11419934), Min Zhao (66793), Zhuo Shen (9136182), Cheng Qin (703381), Lin Wei (70005), Xueying Zhang (460267), Lijiao Deng (11419931), Yaolin Zhang (6000809), Jiyan Zhang (460271), Jiayang Jin (11419925), Ge Li (65539), Gencheng Han (291658), Xueting Zhang (8160114)   +22 more
core   +1 more source

Promotive role of IRF7 in ferroptosis of colonic epithelial cells in ulcerative colitis by the miR-375-3p/SLC11A2 axis

Biomolecules & Biomedicine, 2023
Ferroptosis is implicated in the progression of ulcerative colitis (UC), and interferon regulatory factor 7 (IRF7) contributes to cell death. This study probed the mechanism of IRF7 in ferroptosis of colonic epithelial cells (ECs) in mice with dextran ...
Zepeng Chen, Qinglong Gu, Ruichao Chen
doaj   +1 more source

Zebrafish RPZ5 Degrades Phosphorylated IRF7 To Repress Interferon Production [PDF]

Journal of Virology, 2019
The phosphorylation of IRF7 is helpful for host IFN production to defend against viral infection; thus, it is a potential target for viruses to mitigate the antiviral response. We report that the fish RPZ5 is an IFN negative regulator induced by fish viruses and degrades the phosphorylated IRF7 activated by TBK1, leading to IFN suppression and ...
Long-Feng, Lu, Xiao-Yu, Zhou, Can, Zhang, Zhuo-Cong, Li, Dan-Dan, Chen, Shu-Bo, Liu, Shun, Li   +6 more
openaire   +2 more sources

Kaempferol Alleviates Injury in Human Retinal Pigment Epithelial Cells via STAT1 Ubiquitination-Mediated Degradation of IRF7

Frontiers in Bioscience-Landmark
Background: Retinal pigment epithelial (RPE) cells have a pivotal function in preserving the equilibrium of the retina and moderating the immunological interaction between the choroid and the retina.
Hongjun Zhang, Can Liu, Cao Gu, Jun Jiang, Yu Gao   +4 more
doaj   +1 more source

Interferon regulatory factor 7 mediates obesity-associated MCP-1 transcription.

PLoS ONE, 2020
Hypertrophy, associated with adipocyte dysfunction, causes increased pro-inflammatory adipokine, and abnormal glucose and lipid metabolism, leading to insulin resistance and obesity-related-health problems.
Masashi Kuroda, Misa Nishiguchi, Naho Ugawa, Etsuko Ishikawa, Yasuyo Kawabata, Saya Okamoto, Waka Sasaki, Yumiko Miyatake, Mayu Sebe, Saeko Masumoto, Rie Tsutsumi, Nagakatsu Harada, Hiroshi Sakaue   +12 more
doaj   +1 more source

IRF7-Associated Immunophenotypes Have Dichotomous Responses to Virus/Allergen Coexposure and OM-85-Induced Reprogramming

, 2021
High risk for virus-induced asthma exacerbations in children is associated with an IRF7lo immunophenotype, but the underlying mechanisms are unclear. Here, we applied a Systems Biology approach to an animal model comprising rat strains manifesting high ...
J.F. Lauzon-Joset (23516071), J. Leffler (23482825), M. Serralha (23382898), E. de Jong (23506834), Claus Christophersen (23290996), Alexander Larcombe (23288176), P.G. Holt (23516074), D.H. Strickland (23516077), A. Bosco (17343231)   +8 more
core  

Mechanistic Study on IRF7-mediated Regulation of Learning and Memory Function by Aerobic Exercise in Aged Mice

Shengwu huaxue yu shengwu wuli jinzhan
ObjectiveTo explore the mechanism by which aerobic exercise improves hippocampal neuroinflammation and learning and memory ability in brain-aged mice via interferon regulatory factor 7 (IRF7).MethodsA total of 60 male specific pathogen-free (SPF) C57BL ...
ZHENG Min-Yan, HUANG Xiao-Han, WEI Chang-Ling, ZHANG Yuan-Ting, JIN Yu, LI Xue   +5 more
doaj   +1 more source

Regulation of IRF7 through cell type-specific protein stability [PDF]

Biochemical and Biophysical Research Communications, 2006
Interferon regulatory factor 7 (IRF7) is a key component of the cellular response to virus infection that culminates in physiologically relevant IFNalpha production. We studied molecular mechanisms governing responses to respiratory viral infection that are characterized by transient induction and subsequent shut-off of interferon (IFN) gene expression.
Arun, Prakash, David E, Levy
openaire   +2 more sources

Ro52 ubiquitinates IRF7.

, 2013
(A) HEK293T cells were transfected with 1 µg of the indicated constructs for 18 hrs. Presence of Flag-IRF7, HA-ubiquitin, Xpress-Ro52 and β-actin was detected by immunoblotting.
Rowan Higgs (363081), Elisa Lazzari (363082), Caroline A. Jefferies (327989), Claire Wynne (363083), Alexander Espinosa (363085), Joan Ní Gabhann (363084), Marie Wahren-Herlenius (24329)   +6 more
core   +1 more source

NFATC3 promotes IRF7 transcriptional activity in plasmacy­­toid dendritic cells [PDF]

Journal of Experimental Medicine, 2016
Plasmacytoid dendritic cells (pDCs) rapidly produce large amounts of type 1 interferon (IFN) after Toll-like receptor 7 and 9 engagements. This specialized function of type 1 IFN production is directly linked to the constitutive expression of IRF7, the master transcription factor for type 1 IFN production.
Musheng Bao, York Wang, Ying Liu, Peiqing Shi, Hongbo Lu, Wenwen Sha, Leiyun Weng, Shino Hanabuchi, Jun Qin, Joel Plumas, Laurence Chaperot, Zhiqiang Zhang, Yong-Jun Liu   +12 more
openaire   +2 more sources