Results 51 to 60 of about 24,207 (226)
IRF-7 Is a Critical Regulator of Type 2 Innate Lymphoid Cells in Allergic Airway Inflammation
Cell Reports, 2019 Summary: Allergic asthma is a highly prevalent airway disease triggered by hyperresponsiveness to inhaled allergens. Interferon regulatory factor 7 (IRF7) has been shown to be highly expressed in nasal aspirates from children with asthma.
Juan He +11 more
doaj +1 more source
Myeloid neddylation targets IRF7 and promotes host innate immunity against RNA viruses.
PLoS Pathogens, 2021 Neddylation, an important type of post-translational modification, has been implicated in innate and adapted immunity. But the role of neddylation in innate immune response against RNA viruses remains elusive. Here we report that neddylation promotes RNA
Min Zhao +22 more
doaj +1 more source
Grass Carp (Ctenopharyngodon idella) KAT8 Inhibits IFN 1 Response Through Acetylating IRF3/IRF7
Frontiers in Immunology, 2022 Post-translational modifications (PTMs), such as phosphorylation and ubiquitination, etc., have been reported to modulate the activities of IRF3 and IRF7.
Meifeng Li +9 more
doaj +1 more source
, 2019 (A and B) Schematic diagram to show the regions of IFI204 interacting with IRF7 (upper panels in A and B). Co-immunoprecipitation (IP, with anti-Flag) and immunoblot (IB, with anti-HA) analysis of HEK293T cells that were transfected with plasmids ...
Liu Cao (17875) +11 more
core +1 more source
Bat IRF7 interacts with bat MyD88. (A) Binding of bat IRF7 to bat MyD88.
, 2014 HEK293T cells were transfected with GFP-tagged IRF7 and FLAG-tagged MyD88 (human or bat, as indicated). At 24 h post-transfection, whole cell lysate was prepared and immunoprecipitated with anti-FLAG antibody M2.
Lijun Wu (152858) +8 more
core +1 more source
Advanced Science, EarlyView.Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi +7 more
wiley +1 more source
Information of IRF7 knockdown siRNA.
, 2015 Information of IRF7 knockdown siRNA.
Tae Hyun Kim (91783) +1 more
core +1 more source
Advanced Science, EarlyView.A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo +10 more
wiley +1 more source
Differential Expression Patterns of Irf3 and Irf7 in Pediatric Lymphoid Disorders
The International Journal of Biological Markers, 2007 Interferon regulatory factors (IRFs) are multifunctional transcriptional factors. To define the role of IRFs in lymphoid disorders, we determined the expression patterns of IRF3 and IRF7 by immunohistochemistry in 5 normal lymph nodes, 12 reactive hyperplastic lymph nodes, and 27 pediatric lymphomas.
H S, Park +9 more
openaire +2 more sources
TRIM21 Promotes Rabies Virus Production by Degrading IRF7 through Ubiquitination
International Journal of Molecular Sciences, 2023 Rabies, a highly fatal zoonotic disease, is a significant global public health threat. Currently, the pathogenic mechanism of rabies has not been fully elucidated, and no effective treatment for rabies is available. Increasing evidence shows that the tripartite-motif protein (TRIM) family of proteins participates in the host’s regulation of viral ...
Boyue Zhang +9 more
openaire +2 more sources