Results 61 to 70 of about 24,207 (226)
, 2022 Post-translational modifications (PTMs), such as phosphorylation and ubiquitination, etc., have been reported to modulate the activities of IRF3 and IRF7.
Meifeng Li (6413150) +8 more
core +1 more source
TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma
Advanced Science, EarlyView.TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin +9 more
wiley +1 more source
IFI204 inhibits IRF7 binding with its promoter.
, 2019 (A) CHIP analysis of the specific binding of IRF7 and its promoter DNA. IFI204 or IFI204 mutant was co-transfected with IRF7 into Irf3−/−Irf7−/−MEFs, which were unstimulated (US) or stimulated by SeV.
Liu Cao (17875) +11 more
core +1 more source
Advanced Science, EarlyView.Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu +9 more
wiley +1 more source
Meq interacts with STING and IRF7.
, 2019 (A) The IFN-β-luc, IRF7-luc, or NF-κB-luc reporter was cotransfected with cGAS and STING constructs as well as Meq-Flag plasmid or empty vector into DF-1 cells. After 36 h, cells were harvested and analyzed using the dual-luciferase reporter assay.
Zengkun Xu (7411436) +14 more
core +1 more source
Advanced Science, EarlyView.FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun +13 more
wiley +1 more source
Host genetics of severe influenza: from mouse Mx1 to human IRF7 [PDF]
Current Opinion in Immunology, 2016 Influenza viruses cause mild to moderate respiratory illness in most people, and only rarely devastating or fatal infections. The virulence factors encoded by viral genes can explain seasonal or geographic differences at the population level but are unlikely to account for inter-individual clinical variability.
Michael J Ciancanelli +3 more
openaire +2 more sources
IFI204 promotes the nuclear retention of IRF7.
, 2019 (A) Immunoblot analysis of phosphorylation of IRF7 with rabbit mAb against phospho-IRF7-Ser437/438 (CST D6M2I) and β-actin in NIH3T3 cells infected by lentivirus-mediated shIFI204 or shNC as negative control.
Liu Cao (17875) +11 more
core +1 more source
Frontiers in Cellular and Infection MicrobiologyInterferon regulatory factor 7 (IRF7)-mediated type I interferon antiviral response is crucial for regulating the host following viral infection in chickens.
Zhiyuan Wang +9 more
doaj +1 more source
Large Oncosomes Induce Pro‐Metastatic Stromal‐Myeloid Reprogramming
Advanced Science, EarlyView.Large oncosomes systemically reprogram bone marrow mesenchymal stem cells through innate nucleic acid sensing, driving inflammatory and immunosuppressive remodeling that supports a metastasis‐permissive bone marrow environment, revealing a novel tumor‐host communication axis in cancer. ABSTRACT Bone metastasis can be facilitated by systemic remodeling,
Taylon Felipe Silva +18 more
wiley +1 more source