Results 81 to 90 of about 24,207 (226)

IFI204 inhibits IRF7-mediated activation of type I IFNs responses.

, 2019
(A) qRT-PCR analysis of Ifnb and Ifna4 in Irf3−/−Irf7−/−MEFs transfected with IFI204, IRF3, IRF7 or IRF7-Δ247–467 mutant (IRF7Δ) as indicated. 24 hrs post-transfection, cells stimulated with HSV-1 (MOI = 1) or SeV for 12 hrs as indicated.
Liu Cao (17875), Yu Chen (29959), Shuting Guo (7490861), Yongjia Tong (7109168), Chun-Mei Li (697483), Deyin Guo (201757), Qianyun Liu (4782525), Xiaolu Zhao (776396), Yanxi Ji (7490855), Lanyi Zeng (7490858), Xiaolong Guo (582898), Zhen Zhang (86004)   +11 more
core   +1 more source

RNA‐Binding Proteins Shape Mammalian Retroelement RNA Fate: Lessons From HIV‐1, LINE‐1, and Related Reverse‐Transcribing Elements

Animal Research and One Health, EarlyView.
RNA‐binding proteins (RBPs) and RNA‐associated factors shape retroelement RNA fate by regulating RNA processing, translation, RNP assembly and remodeling, reverse transcription, nuclear trafficking, chromatin engagement, and RNA surveillance. These pathways balance productive retroviral replication or retrotransposon insertion with RNA decay ...
Mingrui Li, Zhangyuan Pan, Yongjuan Guan
wiley   +1 more source

Ro52 mediates its effects by destabilising IRF7.

, 2013
(A) HEK293T cells were transfected with 500 ng of Flag-IRF7, 1 µg of HA-ubiquitin and increasing amounts of Xpress-Ro52 (500 ng, 1 µg and 2 µg) for 18 hrs. Presence of Flag-IRF7, HA-ubiquitin, Xpress-Ro52 and β-actin was detected by immunoblotting.
Rowan Higgs (363081), Elisa Lazzari (363082), Caroline A. Jefferies (327989), Claire Wynne (363083), Alexander Espinosa (363085), Joan Ní Gabhann (363084), Marie Wahren-Herlenius (24329)   +6 more
core   +1 more source

CD14 Plays a Critical Role in Pain and Inflammation Across Multiple Models of Post‐traumatic Osteoarthritis

Arthritis &Rheumatology, EarlyView.
Objective We employed global genetic deletion of CD14 and intra‐articular CD14 blockade across multiple murine osteoarthritis (OA) models that vary in severity of pathology and rate of progression to test the hypothesis that CD14 inhibition attenuates synovial inflammation and associated pain during disease progression.
Kevin G. Burt, Sanique M. South, Natalie S. Adamczyk, Vu Nguyen, Shingo Ishihara, Cheng Zhou, Kate L. Sharp, Sung Y. Kim, Anna E. Rapp, Baofeng Hu, Lance A. Murphy, Li‐Yin Hung, De'Broski Herbert, Joshua F. Baker, Robert L. Mauck, Timothy M. Griffin, Anne‐Marie Malfait, Rachel E. Miller, Carla R. Scanzello   +18 more
wiley   +1 more source

Increased Plasma Microbial tDR‐1 in At‐Risk Individuals Is Associated With Decreased Conversion to Clinical Rheumatoid Arthritis and Reduces an In Vitro Macrophage Type 1 Interferon Response

Arthritis &Rheumatology, EarlyView.
Objective Microbial small RNAs can regulate human genes. Higher plasma concentrations of microbial transfer RNA (tRNA)‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anticyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (
Anastasiia Phothisane, Tulsi K. Joishy, Carolina Ramirez‐Becerra, Qiong Wu, Jennifer Seifert, Marie L. Feser, Jill M. Norris, M. Kristen Demoruelle, LauraKay Moss, Kevin D. Deane, V. Michael Holers, Michelle J. Ormseth   +11 more
wiley   +1 more source

A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines [PDF]

The Journal of Immunology, 2016
Abstract It has been known since the discovery of DNA vaccines >20 y ago that DNA vaccines can function as adjuvants. Our recent study reported the involvement of Aim2 as the sensor of DNA vaccines in eliciting Ag-specific Ab responses.
Suschak, John, Wang, Shixia, Fitzgerald, Katherine A, Lu, Shan   +3 more
openaire   +3 more sources

What Makes an “Ideal” Cell Line for Recombinant Adeno‐Associated Virus Production?

Biotechnology and Bioengineering, EarlyView.
Several host cell types have been used to produce rAAVs to date. Cell line‐specific traits that are beneficial in the context of rAAV manufacturing are reviewed here, with the goal of developing a consensus on the ‘ideal’ characteristics that an rAAV production host should possess (created with Biorender.com).
James Conheady, Nicholas Donohue, Alexandra Bogdanovic, Sharon Davin, Brian Glennon, Niall Barron, C. Mark Smales   +6 more
wiley   +1 more source

Interferon regulatory factor 7- (IRF7-) mediated immune response affects Newcastle disease virus replication in chicken embryo fibroblasts [PDF]

, 2014
Interferon regulatory factor 7 (IRF7) is essential for the induction of an antiviral response. Previous studies have shown that virus replication causes the activation or expression of Type I interferon (IFN) in cells, which further activates IFN ...
Tao Ren, Peng Xie, Zhaoxiong Wang, Xie, Peng, Ning, Zhangyong, Yinfeng Kang, Kang, Yinfeng, Zhangyong Ning, Minhua Sun, Gao, Shimin, Ren, Tao, Shimin Gao, Sun, Minhua, Wang, Zhaoxiong   +13 more
core   +1 more source

RAIDD Mediates TLR3 and IRF7 Driven Type I Interferon Production

Cellular Physiology and Biochemistry, 2016
Background/Aims: Viral infections represent a global health problem with the need for new viral therapies and better understanding of the immune response during infection. The most immediate and potent anti-viral defense mechanism is the production of type I interferon (IFN-I) which are activated rapidly following recognition of viral infection by host
Maney, Sathish Kumar, Xu, Haifeng C., Huang, Jun, Pandyra, Aleksandra A., Ehlting, Christian, Aguilar-Valenzuela, Renan, Pozdeev, Vitaly I., McIlwain, David R., Zimmermann, Albert, Bode, Johannes Georg, Hengel, Hartmut, Kirschning, Carsten J., Kim, Ira R., Hiscott, John, Brenner, Dirk, Häussinger, Dieter, Ohashi, Pamela S., Mak, Tak W., Lang, Karl S., Lang, Philipp A.   +19 more
openaire   +5 more sources

Nanoagonist‐mediated spatiotemporal reprogramming of macrophage phenotypes to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes the major molecular mechanisms governing TAM polarization and their coordinated interactions. It further highlights recent advances in nanoagonist‐based strategies that intervene in these pathways to reprogram TAMs, critically discussing their therapeutic potential, current limitations, and translational prospects.
Siqi Fang, Fengfeng Xiao, Ruie Chen, Cuixia Lu, Yi Ju, Mingqing Yuan, Yunlu Dai, Liewei Wen   +7 more
wiley   +1 more source