Results 1 to 10 of about 293 (70)

Interferon regulatory factor 7 in inflammation, cancer and infection

Frontiers in Immunology, 2023
Interferon regulatory factor 7 (IRF7), a member of the interferon regulatory factors (IRFs) family, is located downstream of the pattern recognition receptors (PRRs)-mediated signaling pathway and is essential for the production of type I interferon (IFN-
Furong Qing, Zhiping Liu
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Enterovirus D68 VP3 Targets the Interferon Regulatory Factor 7 To Inhibit Type I Interferon Response

Microbiology Spectrum, 2023
Enterovirus D68 (EV-D68) is a globally emerging pathogen causing severe respiratory illnesses mainly in children. The protease from EV-D68 could impair type I interferon (IFN-I) production.
Jun Kang, Mengqian Huang, Jinyu Li, Keke Zhang, Cheng Zhu, Sihua Liu, Zhenwei Zhou, Tao Wang, Zhiyun Wang   +8 more
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H1N1 Influenza A Virus Protein NS2 Inhibits Innate Immune Response by Targeting IRF7

Viruses, 2022
Influenza A virus (IAV) is a globally distributed zoonotic pathogen and causes a highly infectious respiratory disease with high morbidity and mortality in humans and animals.
Bo Zhang, Minxuan Liu, Jiaxin Huang, Qiaoying Zeng, Qiyun Zhu, Shuai Xu, Hualan Chen   +6 more
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DHAV-1 Blocks the Signaling Pathway Upstream of Type I Interferon by Inhibiting the Interferon Regulatory Factor 7 Protein

Frontiers in Microbiology, 2021
Duck hepatitis A virus (DHAV), which mainly infects 1- to 4-week-old ducklings, has a fatality rate of 95% and poses a huge economic threat to the duck industry. However, the mechanism by which DHAV-1 regulates the immune response of host cells is rarely
Yalan Lai, Yalan Lai, Yalan Lai, Xiaoyan Xia, Xiaoyan Xia, Xiaoyan Xia, Anchun Cheng, Anchun Cheng, Anchun Cheng, Mingshu Wang, Mingshu Wang, Mingshu Wang, Xumin Ou, Xumin Ou, Xumin Ou, Sai Mao, Sai Mao, Sai Mao, Di Sun, Di Sun, Di Sun, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Dekang Zhu, Dekang Zhu, Renyong Jia, Renyong Jia, Renyong Jia, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu, Xin-Xin Zhao, Xin-Xin Zhao, Xin-Xin Zhao, Juan Huang, Juan Huang, Juan Huang, Qun Gao, Qun Gao, Qun Gao, Bin Tian, Bin Tian, Yunya Liu, Yunya Liu, Yunya Liu, Yanling Yu, Yanling Yu, Yanling Yu, Ling Zhang, Ling Zhang, Ling Zhang, Leichang Pan, Leichang Pan   +62 more
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MicroRNA-31 mediated by interferon regulatory factor 7 signaling facilitates control of Mycobacterium tuberculosis infection

International Journal of Medical Microbiology, 2022
Tuberculosis (TB) induced by Mycobacterium tuberculosis (M. tuberculosis) infection remains a global most deadly infectious disease. While development of more effective TB vaccines and therapeutics relies on identifications of true biomarkers designating
Zhiyi Zhang, Qiongdan Mai, Lijia Yang, Yiwei Chen, Zixu Chen, Tao Lin, Shimin Tan, Zhiying Wu, Yongjie Cai, Taimei Cui, Beiyin Ouyang, Yi Yang, Lingchan Zeng, Zhenhuang Ge, Sien Zhang, Gucheng Zeng, Jiang Pi, Lingming Chen   +17 more
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Role of interferon regulatory factor 7 in corneal endothelial cells after HSV-1 infection

Scientific Reports, 2021
Viral infections of the cornea including herpes simplex virus 1 (HSV-1) cause visual morbidity, and the corneal endothelial cell damage leads to significant visual impairment.
Fumie Ohtani, Dai Miyazaki, Yumiko Shimizu, Tomoko Haruki, Satoru Yamagami, Yoshitsugu Inoue   +5 more
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Chicken anemia virus VP1 negatively regulates type I interferon via targeting interferon regulatory factor 7 of the DNA-sensing pathway

Poultry Science, 2023
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway plays a vital role in sensing viral DNA in the cytosol, stimulating type I interferon (IFN) production and triggering the innate immune response against DNA virus
Xuelan Liu, Dexian Xi, Aiyun Xu, Yuan Wang, Tao Song, Tiantian Ma, Hong Ye, Lin Li, Fazhi Xu, Hao Zheng, Jinnian Li, Feifei Sun   +11 more
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Interferon regulatory factor 7 mediates obesity-associated MCP-1 transcription.

PLoS ONE, 2020
Hypertrophy, associated with adipocyte dysfunction, causes increased pro-inflammatory adipokine, and abnormal glucose and lipid metabolism, leading to insulin resistance and obesity-related-health problems.
Masashi Kuroda, Misa Nishiguchi, Naho Ugawa, Etsuko Ishikawa, Yasuyo Kawabata, Saya Okamoto, Waka Sasaki, Yumiko Miyatake, Mayu Sebe, Saeko Masumoto, Rie Tsutsumi, Nagakatsu Harada, Hiroshi Sakaue   +12 more
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Duck Enteritis Virus Protein Kinase US3 Inhibits DNA Sensing Signaling by Phosphorylating Interferon Regulatory Factor 7

Microbiology Spectrum, 2022
The cytosolic DNA sensing pathway mediates innate immune defense against infection by many DNA viruses; however, viruses have evolved multiple strategies to evade the host immune response. Duck enteritis virus (DEV) causes an acute and contagious disease
Rui Liu, Li Gao, Fuchun Yang, Xiaohan Li, Changjun Liu, Xiaole Qi, Hongyu Cui, Yanping Zhang, Suyan Wang, Xiaomei Wang, Yulong Gao, Kai Li   +11 more
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Augmented interferon regulatory factor 7 axis in whole tumor cell vaccines prevents tumor recurrence by inducing interferon gamma-secreting B cells

OncoImmunology, 2023
Among cancer immunotherapy, which has received great attention in recent years, cancer vaccines can potentially prevent recurrent tumors by using the exquisite power and specificity of the immune system.
Nabeel Kajihara, Yoshino Tanaka, Riko Takeuchi, Takuto Kobayashi, Masafumi Tanji, Tsukasa Ataka, Shiho Nakano, Taisho Yamada, Akinori Takaoka, Yoshinori Hasegawa, Ken-Ichiro Seino, Haruka Wada   +11 more
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