Results 31 to 40 of about 91,971,061 (239)

Cloning and Expression of irf7 Gene in Spotted Knifejaw (Oplegnathus punctatus) Under Virus Infection

Progress in Fishery Sciences, 2023
Interferon regulatory factor (irf7) is an immune regulatory factor that plays an important role in the antiviral process. To explore the role of irf7 in Oplegnathus punctatus (Temminck & Schlegel, 1844) under viral infection, we cloned the coding DNA ...
Yu SONG, Kaimin LI, Wenteng XU, Songlin CHEN, Lei WANG   +4 more
doaj   +1 more source

CD25(+) Natural Regulatory T Cells Are Critical in Limiting Innate and Adaptive Immunity and Resolving Disease following Respiratory Syncytial Virus Infection [PDF]

, 2010
Regulatory CD4(+) T cells have been shown to be important in limiting immune responses, but their role in respiratory viral infections has received little attention.
Harker, JA, Johansson, C, Cecilia Johansson, Tregoning, John S, Jürgen Schwarze, Atabani, Sowsan F, Lee, Debbie C P, Atabani, SF, Lee, DC, Harker, James A E, Peter J. M. Openshaw, Schwarze, J, Harker, JAE, James A. E. Harker, Openshaw, Peter J M, Tregoning, JS, Lee, DCP, Johansson, Cecilia, John S. Tregoning, Openshaw, PJ, Schwarze, Jürgen, Openshaw, PJM, Debbie C. P. Lee, Sowsan F. Atabani   +23 more
core   +1 more source

Interferon regulatory factor 7 regulates glioma stem cells via interleukin-6 and Notch signalling [PDF]

, 2012
Inflammatory microenvironment signalling plays a crucial role in tumour progression (i.e. cancer cell proliferation, survival, angiogenesis and metastasis) in many types of human malignancies.
Yin, J, Lee, SH, Song, MS, Lee, JH, Jeon, HM, Kim, SH, Beck, S, Park, JB, Kim, JK, Kim, H, Kang, SH, Nam, DH, Lim, YC, Jin, X, Pian, X, Chae, YS, Choi, YJ, Choi, YK, Chung, YG, Sohn, YW   +19 more
core   +1 more source

GDF15 Suppresses Lymphoproliferation and Humoral Autoimmunity in a Murine Model of Systemic Lupus Erythematosus

Journal of Innate Immunity, 2022
Growth and differentiation factor 15 (GDF15), a divergent member of the transforming growth factor-β superfamily, has been associated with acute and chronic inflammatory conditions including autoimmune disease, i.e., type I diabetes and rheumatoid ...
Georg Lorenz, Andrea Ribeiro, Ekatharina von Rauchhaupt, Vivian Würf, Christoph Schmaderer, Clemens D. Cohen, Twinkle Vohra, Hans-Joachim Anders, Maja Lindenmeyer, Maciej Lech   +9 more
doaj   +1 more source

Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo [PDF]

, 2008
The early systemic production of interferon (IFN)-alphabeta is an essential component of the antiviral host defense mechanisms, but is also thought to contribute to the toxic side effects accompanying gene therapy with adenoviral vectors.
György Fejer, Hildenbrand, B., Schleicher, U, Hildenbrand, Bernd, Marina A Freudenberg, Fejer, G., Greber, U., Ruzsics, Zsolt, Drechsel, Lisa, Fejer György, Imelli, N., Imelli, N, Ruzsics, Z., Krug Anne, Christian Bogdan, Keck, S., Zsolt Ruzsics, Lisa Drechsel, Hildenbrand Bernd, Drechsel, L., Simone Keck, Schleicher, Ulrike, Bogdan, C, Liese, J., Freudenberg, M., Bogdan, C., Schleicher Ulrike, Bogdan Christian, Ulrike Schleicher, Keck Simone, Krug, A., Fejer, György, Schleicher, U., Bogdan, Christian, Greber Urs F., Freudenberg, M A, Nicola Imelli, Krug, A, Greber, Urs F., Drechsel Lisa, Keck, S, Liese Jan, Krug, Anne, Jan Liese, Drechsel, L, Ruzsics, Z, Ruzsics Zsolt, Hildenbrand, B, Imelli, Nicola, Freudenberg, Marina A., Freudenberg Marina A., Bernd Hildenbrand, Urs F Greber, Fejer, G, Liese, J, Keck, Simone, Anne Krug, Greber, U F, Imelli Nicola, Liese, Jan   +59 more
core   +2 more sources

Molecular mechanisms of IL-18BP regulation in DLD-1 cells: pivotal direct action of the STAT1/GAS axis on the promoter level [PDF]

, 2008
Interleukin (IL)-18, formerly known as interferon (IFN)-γ-inducing factor, is a crucial mediator of host defence and inflammation. Control of IL-18 bioactivity by its endogenous antagonist IL-18 binding protein (IL-18BP) is a major objective of ...
Jens Paulukat, Heiko Mühl, Malte Bachmann, Josef Pfeilschifter, Pfeilschifter, Josef, Bachmann, Malte, Mühl, Heiko, Paulukat, Jens   +7 more
core   +1 more source

IRF7: role and regulation in immunity and autoimmunity

Frontiers in Immunology, 2023
Interferon regulatory factor (IRF) 7 was originally identified as master transcriptional factor that produced IFN-I and regulated innate immune response, subsequent studies have revealed that IRF7 performs a multifaceted and versatile functions in ...
Wei Ma, Wei Ma, Gang Huang, Zhi Wang, Li Wang, Qiangguo Gao   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Topical Application of a Vitamin A Derivative and Its Combination With Non-ablative Fractional Laser Potentiates Cutaneous Influenza Vaccination

Frontiers in Microbiology, 2018
Skin contains a large number of antigen presenting cells, making intradermal (ID) injection one of the most effective ways for vaccine administration. However, although current adjuvants may cause severe local reactions and inflammations in the skin, no ...
Peiyu Li, Peiyu Li, Peiyu Li, Ji Wang, Ji Wang, Miao Cao, Qiwen Deng, Shibo Jiang, Shibo Jiang, Mei X. Wu, Mei X. Wu, Lu Lu   +11 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source