Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA [PDF]
, 2009 U1-snRNA is an integral part of the U1 ribonucleoprotein pivotal for pre-mRNA splicing. Toll-like receptor (TLR) signaling has recently been associated with immunoregulatory capacities of U1-snRNA.
Pfeilschifter, Josef (Prof. Dr.) +3 more
core +1 more source
Epstein-Barr Virus LF2: an Antagonist to Type 1 Interferon [PDF]
, 2009 Upon viral infection, the major defense mounted by the host immune system is activation of the interferon (IFN)-mediated antiviral pathway, which is mediated by IFN regulatory factors (IRFs).
Shin, Young Chul +8 more
core +1 more source
Interferon regulatory factor-7 modulates experimental autoimmune encephalomyelitis in mice
Journal of Neuroinflammation, 2011 Background Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) with unknown etiology. Interferon-β (IFN-β), a member of the type I IFN family, is used as a therapeutic for MS and the IFN signaling pathway is implicated ...
Salem Mohammad +4 more
doaj +1 more source
IKKε isoform switching governs the immune response against EV71 infection
Communications Biology, 2021 Chang et al. show that Enterovirus 71 (EV71) infection upregulates IKKε isoform 2 (IKKε v2), which in turn activates interferon regulatory factor 7 (IRF7).
Ya-Ling Chang +6 more
doaj +1 more source
Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection [PDF]
, 2012 Abnormal prion protein (PrP Sc) generated from the cellular isoform of PrP (PrP C) is assumed to be the main or sole component of the pathogen, called prion, of transmissible spongiform encephalopathies (TSE).
Yamaguchi, Naohiro +7 more
core +1 more source
IRF1 (interferon regulatory factor 1) [PDF]
, 2008 Review on IRF1 (interferon regulatory factor 1), with data on DNA, on the protein encoded, and where the gene is ...
Palladinetti, P +5 more
core +1 more source
IRF4 (interferon regulatory factor 4) [PDF]
, 2009 Review on IRF4 (interferon regulatory factor 4), with data on DNA, on the protein encoded, and where the gene is ...
Rasi, S, Gaidano, G
core +1 more source
Transcriptional responses of tumor cell lines to interferon-alpha [PDF]
, 2013 Interferon is an antiviral and antiproliferative cytokine therapeutically applied to treat hepatitis infection and cancer expansion. The beneficial effects of interferon-alpha are dependent on efficient signaling by activation of defined JAK-STAT pathway
Siegrist, Fredy
core +1 more source
Of Mice and Men and Cattle: Functions of the Pneumovirus Nonstructural Proteins NS1 and NS2 in Interferon Escape [PDF]
, 2003 Bovine respiratory syncytial virus (BRSV), family Paramyxoviridae, subfamily Pneumovirinae, is a major etiological agent of respiratory tract disease in calves. A peculiarity of pneumoviruses is the presence of two unique nonstructural protein genes, NS1
Bossert, Birgit
core +1 more source
Agricultura Tropica et Subtropica, 2021 The interferon regulatory factor gene family encodes transcription factors with multiple biological functions, which include reproduction, cell differentiation and immunity.
Durosaro Samuel Olutunde +3 more
doaj +1 more source