Results 11 to 20 of about 91,971,061 (239)

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson’s disease [PDF]

Neural Regeneration Research
Interferon regulatory factor 7 plays a crucial role in the innate immune response. However, whether interferon regulatory factor 7-mediated signaling contributes to Parkinson’s disease remains unknown.
Shengyang Zhou, Ting Li, Wei Zhang, Jian Wu, Hui Hong, Wei Quan, Xinyu Qiao, Chun Cui, Chenmeng Qiao, Weijiang Zhao, Yanqin Shen   +10 more
doaj   +3 more sources

Reconstitution of interferon regulatory factor 7 expression restores interferon beta induction in Huh7 cells [PDF]

Journal of Virology
Abundance of essential components of double-stranded RNA (dsRNA) recognition and the subsequent interferon (IFN) response vary widely between primary human hepatocytes (PHHs) and commonly used cell culture models based on derivatives of Huh7 cells ...
Andreas Betz, Hao-En Huang, Zuguang Gu, Ombretta Colasanti, Teng-Feng Li, Jasper Hesebeck-Brinckmann, Nadine Gillich, Gnimah Eva Gnouamozi, Matthias Schlesner, Florian W. R. Vondran, Stephan Urban, Ralf Bartenschlager, Marco Binder, Volker Lohmann   +13 more
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Macrophage interferon regulatory factor 7 aggravates the progression of metabolic dysfunction-associated steatohepatitis [PDF]

Molecular Biomedicine
Metabolic dysfunction-associated steatohepatitis (MASH) represents a growing clinical burden with increasing prevalence and lacking approved pharmacological therapies.
Xuhao Ni, Qingfa Bu, Yuan Liang, Bozhou Pan, Jian Wang, Qingxiang Xu, Lei Liu, Qi Wang   +7 more
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miR-541-3p Promoted Porcine Reproductive and Respiratory Syndrome Virus 2 (PRRSV-2) Replication by Targeting Interferon Regulatory Factor 7 [PDF]

Viruses, 2022
Porcine reproductive and respiratory syndrome (PRRS) is a disease caused by PRRS virus (PRRSV), which seriously harms the pig industry. Revealing the mechanism by which PRRSV inhibits immune response will help prevent and control PRRS.
Xibao Shi, Yuanhao Yang, Xiaozhuan Zhang, Xiaobo Chang, Jing Chen, Chao Wang, Aiping Wang, Jianhua Wang, Jianru Qin, Xianlong Ye, Wei Jin, Gaiping Zhang   +11 more
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Interferon regulatory factor 7 alleviates the experimental colitis through enhancing IL-28A-mediated intestinal epithelial integrity [PDF]

Journal of Translational Medicine
Background The incidence of inflammatory bowel disease (IBD) is on the rise in developing countries, and investigating the underlying mechanisms of IBD is essential for the development of targeted therapeutic interventions. Interferon regulatory factor 7
Furong Qing, Hongbo Tian, Biyao Wang, Bingyu Xie, Lina Sui, Xiaoyan Xie, Wenji He, Tiansheng He, Yumei Li, Liangmei He, Qin Guo, Zhiping Liu   +11 more
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N-myc and STAT interactor degrades interferon regulatory factor 7 mediated type I interferon signaling to promote duck Tembusu virus replication [PDF]

Poultry Science
: N-myc and STAT interactor (NMI) is an interferon-induced protein, which plays a variety of biological functions by participating in signal transduction and transcriptional activation, it has been reported to regulate antiviral response of different ...
Wanshuang Luo, Wenjun Cai, Anchun Cheng, Mingshu Wang, Shun Chen, Juan Huang, Qiao Yang, Ying Wu, Di Sun, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Shaqiu Zhang, Xumin Ou, Bin Tian, Zhongqiong Yin, Renyong Jia   +16 more
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Type I interferon drives T cell cytotoxicity by upregulation of interferon regulatory factor 7 in autoimmune kidney diseases in mice [PDF]

Nature Communications
In anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) and systemic lupus erythematosus (SLE), glomerulonephritis is a severe kidney complication driven by immune cells, including T cells. However, the mechanisms underlying T cell activation
Huiying Wang, Jonas Engesser, Robin Khatri, Darius P. Schaub, Hans-Joachim Paust, Zeba Sultana, Saskia-Larissa Jauch-Speer, Anett Peters, Anna Kaffke, Stefan Bonn, Tobias B. Huber, Hans-Willi Mittrücker, Christian F. Krebs, Ulf Panzer, Nariaki Asada   +14 more
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Infectious bursal disease virus affecting interferon regulatory factor 7 signaling through VP3 protein to facilitate viral replication [PDF]

Frontiers in Cellular and Infection Microbiology
Interferon regulatory factor 7 (IRF7)-mediated type I interferon antiviral response is crucial for regulating the host following viral infection in chickens.
Zhiyuan Wang, Yang Chen, Yanyan Chen, Rui Chen, Weiwei Wang, Shichen Hu, Yihai Li, Hongjun Chen, Ping Wei, Xiumiao He   +9 more
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Avian leukosis virus p15 interacts with interferon regulatory factor 7 to antagonize the cGAS-STING signaling pathway and promote viral replication [PDF]

Journal of Virology
Cyclic GMP-AMP synthase (cGAS) recognizes viral DNA within the cytoplasm and initiates innate antiviral response through the cGAS-STING pathway. However, viruses have evolved diverse strategies to counteract the cGAS-STING signaling pathway.
Zhouhao Cui, Kui Shen, Moru Xu, Yongxiu Yao, Hongxia Shao, Aijian Qin, Kun Qian   +6 more
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Evaluation of the peripheral blood T and B cell subsets and IRF‐7 variants in adult patients with severe influenza virus infection

Health Science Reports, 2022
Background and Aims Influenza virus is one of the leading infections causing death among human being. Despite known risks, primary immune deficiency due to Interferon Regulatory Factor‐7 (IRF7) gene defect was reported as a possible cause of the risk ...
Nursel Çalık Başaran, Çağman Tan, Lale Özışık, Begüm Özbek, Ahmet Çağkan İnkaya, Şehnaz Alp, Ebru Ortaç Ersoy, Deniz Çağdaş Ayvaz, İlhan Tezcan   +8 more
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