Results 51 to 60 of about 91,971,061 (239)

Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer. [PDF]

, 2016
UNLABELLED Interferon regulatory factor 3 (IRF3) is a transcription factor involved in the activation of type I alpha/beta interferon (IFN-α/β) in response to viral infection.
Ruggli, Nicolas, Gottipati, Keerthi, Holthauzen, Luis Marcelo F, Choi, Kyung H   +3 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Gene structures and promoter characteristics of interferon regulatory factor 1 (IRF-1), IRF-2 and IRF-7 from snakehead Channa argus

, 2008
Three interferon regulatory factor (IRF) genes, CaIRF-1, CaIRF-2 and CaIRF-7, and their promoters of snakehead (Channa argus) were cloned and characterized.
Guo, Qionglin, Jia, Weizhang, Guo, QL, Chinese Acad Sci, Inst Hydrobiol, Ctr Fishery Biotechnol, Wuhan 430072, Peoples R China   +2 more
core   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Differential Regulation of Human Interferon A Gene Expression by Interferon Regulatory Factors 3 and 7 [PDF]

, 2009
Differential expression of the human interferon A (IFN-A) gene cluster is modulated following paramyxovirus infection by the relative amounts of active interferon regulatory factor 3 (IRF-3) and IRF-7.
Hiscott, John, Civas, Ahmet, Lin, Rongtuan, Génin, Pierre, Ahmet Civas, Rongtuan Lin, Pierre Génin, John Hiscott   +7 more
core   +1 more source

A hyperactive mutant of interferon-regulatory factor 4

, 2022
We found that deletion of the final 30 amino acids of transcription factor IRF4's (interferon‐regulatory factor) C‐terminus creates hyperactive IRF4.
Hartmann, Enno, Porapu, Alekya, Lohoff, Michael, Menke, Lisa, Pinkenburg, Olaf, Raifer, H, Camara, B, Bieringer, Maria, Kang, Chol-Ho, Staudenraus, Daniel, Abass, E, Bruestle, Anne   +11 more
core   +1 more source

Research advances in the role of interferon regulatory factor 4(IRF4) in chronic inflammatory diseases [PDF]

, 2022
Interferon regulatory factor 4 (IRF4) is expressed in a variety of immune cells and participates in the regulation of a variety of immune responses.
LUAN Ge, WANG Ming, WANG Cheng-shuo, ZHANG Luo
core   +1 more source

TRIM21 regulation of IRF-mediated type I interferon signaling in systemic autoimmune diseases

Frontiers in Immunology
Dysregulation of type I interferon (IFN-I) signaling has been implicated in the pathogenesis of multiple systemic autoimmune diseases, including systemic lupus erythematosus, Sjögren’s syndrome, and rheumatoid arthritis.
Kailai Panlu, Yihan Wang, Xinchao Zhu, Zhiting Lin, Ting Fang, Xinyi Yao, Zhimin Xie, Xinchang Wang   +7 more
doaj   +1 more source

IRF7 as an Immune-Related Prognostic Biomarker and Associated with Tumor Microenvironment in Low-Grade Glioma

International Journal of General Medicine, 2021
Shijun Peng, Guangyu Wang, Zhihua Cheng, Zhilin Guo Department of Neurosurgery, The Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University Medical College, Shanghai, 200001, People’s Republic of ChinaCorrespondence: Zhihua Cheng; Zhilin Guo ...
Peng S, Wang G, Cheng Z, Guo Z
doaj  

Interferon Regulatory Factors IRF1 and IRF7 Directly Regulate Gene Expression in Bats in Response to Viral Infection

Cell Reports, 2020
Summary: Bat cells and tissue have elevated basal expression levels of antiviral genes commonly associated with interferon alpha (IFNα) signaling. Here, we show Interferon Regulatory Factor 1 (IRF1), 3, and 7 levels are elevated in most bat tissues and ...
Aaron T. Irving, Qian Zhang, Pui-San Kong, Katarina Luko, Pritisha Rozario, Ming Wen, Feng Zhu, Peng Zhou, Justin H.J. Ng, Radoslaw M. Sobota, Lin-Fa Wang   +10 more
doaj   +1 more source