Results 71 to 80 of about 91,971,061 (239)

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

IRF-7 Is a Critical Regulator of Type 2 Innate Lymphoid Cells in Allergic Airway Inflammation

Cell Reports, 2019
Summary: Allergic asthma is a highly prevalent airway disease triggered by hyperresponsiveness to inhaled allergens. Interferon regulatory factor 7 (IRF7) has been shown to be highly expressed in nasal aspirates from children with asthma.
Juan He, Qiong Yang, Qiang Xiao, Aihua Lei, Xing Li, Pan Zhou, Ting Liu, Lijuan Zhang, Kun Shi, Quan Yang, Junchao Dong, Jie Zhou   +11 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Mycobacterial purified protein derivatives stimulate innate immunity: Malawians show enhanced tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses compared to those of adolescents in the United Kingdom. [PDF]

, 2004
To investigate the role of innate immunity in variable efficacy of Mycobacterium bovis BCG vaccination in Malawi and the United Kingdom, we examined 24-h tumor necrosis factor alpha, interleukin-1beta (IL-1beta), and IL-10 responses to mycobacterial ...
Elizabeth King, King, Elizabeth, Jarman, Elizabeth, Hazel M. Dockrell, Lifted Sichali, Fine, Paul E.M., Blackwell, Jenefer M., Weir, Rosemary E., Elizabeth Jarman, Sally Stenson, Nazareth, Bernadette, Warndorff, David K., Crampin, Amelia C, Black, Gillian F, Stenson, Sally, Mwaungulu, Lorren, Amelia C. Crampin, Linda Donovan, Blackwell, Jenefer M, Rosemary E. Weir, Paul E. M. Fine, Sian Floyd, Bernadette Nazareth, Fine, Paul EM, David K. Warndorff, Black, Gillian F., Crampin, Amelia C., Dockrell, Hazel M., Jenefer M. Blackwell, Floyd, Sian, Chaguluka, Steven D, Lorren Mwaungulu, Sichali, Lifted, Donovan, Linda, Steven D. Chaguluka, Warndorff, David K, Weir, Rosemary E, Chaguluka, Steven D., Dockrell, Hazel M, Ngwira, Bagrey, Bagrey Ngwira, Gillian F. Black   +41 more
core   +1 more source

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Interferon-α action in cytokine profile in eosinophilic nasal polyp cultures

, 2021
Introduction Chronic rhinosinusitis is currently classified into two types: chronic rhinosinusitis without nasal polyps and chronic rhinosinusitis with nasal polyps.
Júlio Cláudio Sousa (12651722), Eddie Fernando Cândido Murta (12651734), Márcia Antoniazi Michelin (12651737), Renata Margarida Etchbehere (12651725), Letícia Montes Stark (12651731), Eduardo Arthur Rodovalho Alves (12651728)   +5 more
core   +1 more source

IRF7 Protects Against Severe Influenza A Infection Independently of TLR7 Recognition in Mice

Viruses
Influenza A virus (IAV) remains a major cause of respiratory morbidity and mortality worldwide. However, the precise role of the RNA sensor Toll-like receptor 7 (TLR7) and its downstream signaling mediator, interferon regulatory factor 7 (IRF7), during ...
Ana Karina Nisperuza Vidal, Chenxiao Wang, Michaela J. Allen, Xiaofeng Ding, Jefferson Fernandes Evangelista, Yilin Chen, Mst Shamima Khatun, Micaela R. Boxer Wachler, Calder R. Ellsworth, Mohammad Islamuddin, Robert Blair, Jay K. Kolls, Derek A. Pociask, Xuebin Qin   +13 more
doaj   +1 more source

Influenza Vaccination Responses in Disabled Stroke Patients: A Single‐Center Prospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao, Sureerat Suwatcharangoon, Pintip Ngamjanyapron, Kobporn Boonnak, Thanitta Suangtamai, Porpon Rotjanapan   +5 more
wiley   +1 more source

Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding.

, 2002
Interferon regulatory factor 7 (IRF7) is an interferon-inducible transcription factor required for induction of delayed early interferon alpha genes and the onset of a potent antiviral state.
Marié, Isabelle, Prakash, Arun, Caillaud, Alexandre, Smith, Eric, Levy, David E, Masumi, Atsuko, Hovanessian, Ara G   +6 more
core   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source