Results 81 to 90 of about 91,971,061 (239)

Interferon regulatory factor 3 in adaptive immune responses.

, 2014
Interferon regulatory factor (IRF) 3 plays a key role in innate responses against viruses. Indeed, activation of this transcription factor triggers the expression of type I interferons and downstream interferon-stimulated genes in infected cells.
Ysebrant De Lendonck, Laure, Martinet, Valérie, Goriely, Stanislas   +2 more
core   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Interferon regulatory factor 7: a key cellular mediator of LMP-1 in EBV latency and transformation [PDF]

, 2001
Interferon regulatory factor 7 (IRF-7) was cloned within the biological context of Epstein–Barr virus (EBV) latency, and has an intimate relation with EBV. EBV latent membrane protein 1 (LMP-1) regulates IRF-7 both by inducing the expression of IRF-7 and
Zhang, Luwen, Pagano, Joseph S.
core  

Bunyaviruses and the type I interferon system [PDF]

, 2009
The family Bunyaviridae contains more than 350 viruses that are distributed throughout the world. Most members of the family are transmitted by arthopods, and several cause disease in man, domesticated animals and crop plants. Despite being recognized as
Richard M. Elliott, Weber, F., Richard Elliott, Elliott, Richard Michael, Friedemann Weber, Weber, F, Elliott, R.M.   +6 more
core   +1 more source

Genome-wide analysis reveals the MORC3-mediated repression of PD-L1 expression in head and neck cancer

Frontiers in Cell and Developmental Biology
IntroductionProgrammed death-ligand 1 (PD-L1) plays essential roles in the negative regulation of anti-tumor immunity. However, the regulatory mechanisms of PD-L1 expression need further exploration.
Wenxuan Fu, Wenxuan Fu, Xiaomeng Chang, Xiaomeng Chang, Xiaomeng Chang, Kun Ye, Kun Ye, Zige Zheng, Zige Zheng, Qianyi Lai, Qianyi Lai, Minyang Ge, Minyang Ge, Yan Shi, Yan Shi, Yan Shi   +15 more
doaj   +1 more source

CSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio   +19 more
wiley   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

IRF7 is a novel prognostic biomarker in kidney renal clear cell carcinoma

Scientific Reports
Interferon regulatory factor 7 (IRF7) regulates immune responses but its prognostic role in kidney renal clear cell carcinoma (KIRC) is undefined. Given KIRC’s high incidence (70–80% of renal cancers) and limited late-stage therapies, we assessed IRF7’s ...
Shuangshuang Fu, Wenhui Zhou, Wei Yin, Ying Chen, Liyuan Cao, Yusa Chen, Zheng Xiao   +6 more
doaj   +1 more source

Expression, polymorphism of IRF5 gene and association with serum cytokine levels in pig

Italian Journal of Animal Science, 2018
Interferon regulatory factor 5 (IRF5) gene is a crucial transcription factor in immune system and has shown its functionally diverse roles in the regulation of antiviral responses.
Yang Liu, Rui Xie, Hejun Li, Zhengzheng Hu, Shiwei Wang, Zongjun Yin   +5 more
doaj   +1 more source