Results 91 to 100 of about 91,971,061 (239)

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

Activation of the interferon induction cascade by influenza A viruses requires viral RNA synthesis and nuclear export [PDF]

, 2014
This work is supported by grants from the Wellcome Trust (grants 087751/A/08/Z) and MRC (G1001726/1).We have examined the requirements for virus transcription and replication and thus the roles of input and progeny genomes in the generation of interferon
Randall, Richard E, Smith, Matt, Killip, Marian J, Jackson, David, Randall, Richard E; id_orcid   +4 more
core   +1 more source

Late phase inhibition of murine cytomegalovirus replication by synergistic action of interferon-gamma and tumour necrosis factor [PDF]

, 1994
We have shown previously that the antiviral function of CD4+ T lymphocytes against murine cytomegalovirus (MCMV) is associated with the release of interferon- (IFN-).
Koszinowski, Ulrich H., Lucin, Pero, Messerle, Martin, Polic, Bojan, Jonjic, Stipan, Hengel, Hartmut   +5 more
core   +1 more source

Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3

, 2011
Kaposi's sarcoma-associated herpesvirus (KSHV) encodes four viral interferon regulatory factors (vIRF-1-4). We investigated the mechanism and consequences of vIRF-2-mediated inhibition of interferon-response element signalling following type 1 interferon
Hindle, Laura, L. M. Butler, K. Shah, Hindle, L, Lowry, K, S. A. Chanas, Mutocheluh, Mohamed, K. Lowry, Lowry, K., Shah, K., Chanas, Simon, Chanas, SA, D. J. Blackbourn, Areste, C., M. Mutocheluh, Aresté, C, Butler, Lucilla, Butler, LM, Shah, K, Blackbourn, DJ, L. Hindle, Blackbourn, David, C. Aresté, Chanas, S. A., Lowry, Kym, Mutocheluh, M, Blackbourn, D. J., Mutocheluh, M., Evans, DJ, Evans, David J., D. J. Evans, Hindle, L., Evans, D. J., Butler, L. M., Evans, D. J.; id_orcid   +34 more
core   +2 more sources

Development and characterization of a new cell line derived from European eel Anguilla anguilla kidney

Biology Open, 2019
A new cell line derived from the kidney of European eel, Anguilla anguilla, has been established and characterized. This cell line, designated as EK (eel kidney), has been maintained in Leibovitz's L-15 supplemented with 10% fetal bovine serum for over ...
Bin Chen, Zaiyu Zheng, Jinxian Yang, Hongshu Chi, He Huang, Hui Gong   +5 more
doaj   +1 more source

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source

Protective Role of the Host Innate Immune System in Prion Pathogenesis [PDF]

, 2019
Prion diseases, including human Creutzfeldt-Jakob disease, are infectious, intractable central neurodegenerative diseases, which are also zoonoses that commonly infect not only higher organisms but also a wide variety of animals.Pathogenic prions induce
石橋, 大輔
core   +1 more source

Chicken IRF10 suppresses the cGAS-STING-IFN antiviral signaling pathway by targeting IRF7

Frontiers in Immunology
IntroductionThe innate immune cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING)-interferon (IFN) signaling axis is a cornerstone of antiviral innate immunity in chickens, with chicken interferon regulatory factor 7 (chIRF7) serving as
Sen Jiang, Sen Jiang, Sen Jiang, Sen Jiang, Jingyu He, Jingyu He, Jingyu He, Jingyu He, Kun Wang, Kun Wang, Kun Wang, Kun Wang, Mengjia Lv, Mengjia Lv, Mengjia Lv, Mengjia Lv, Hongjian Han, Hongjian Han, Hongjian Han, Hongjian Han, Bingjie Sun, Bingjie Sun, Bingjie Sun, Bingjie Sun, Nanhua Chen, Nanhua Chen, Nanhua Chen, Nanhua Chen, Wanglong Zheng, Wanglong Zheng, Wanglong Zheng, Wanglong Zheng, Jianzhong Zhu, Jianzhong Zhu, Jianzhong Zhu, Jianzhong Zhu   +35 more
doaj   +1 more source

Biomimetic Hybrid‐Membrane Nanoreactor for Deep‐Seated Photodynamic Immunotherapy of Hepatocellular Carcinoma via Dual Catalysis‐Enhanced ROS Amplification and cGAS‐STING Activation

Advanced Functional Materials, EarlyView.
UCNP@MnOx‐Hyp@HRM (UMHM) enables tumor targeting and accumulation. Under 808 nm NIR irradiation, PDT/CDT synergistically triggers ICD and cGAS–STING immunity for deep hepatocellular carcinoma therapy. ABSTRACT Photodynamic therapy (PDT) is promising against hepatocellular carcinoma (HCC).
Wen Li, Jianzhang Luo, Pei Lu, Dongqing Liu, Huijun Yi, Xiaoyuan Yi, Bixia Chi, Wen Chen, Qingyu Zeng, Feifei He, Liyan Wang   +10 more
wiley   +1 more source

Atom‐Efficient Cerium‐Based Molecular Cages as Biocompatible Reactive Oxygen Scavengers

Advanced Healthcare Materials, EarlyView.
Discrete mixed‐valent cerium molecular cages organize accessible redox centers within confined coordination environments and scavenge superoxide, hydrogen peroxide, and hydroxyl radicals. Encapsulation of the lead cage in an ROS‐responsive DTP nanoplatform enables lesion‐associated delivery, attenuates macrophage oxidative stress and inflammation, and ...
Chao Li, Chunbai Xiang, Ye Xu, Yu Liu, Keze Hong, Fanchu Zeng, Gelin Xu, Zhao‐Xi Wang, Jonathan L. Sessler, Ping Gong   +9 more
wiley   +1 more source