Results 111 to 120 of about 91,971,061 (239)

Avian Reovirus σA Protein Inhibits Type I Interferon Production by Abrogating Interferon Regulatory Factor 7 Activation. [PDF]

J Virol, 2023
Gao L, Liu R, Luo D, Li K, Qi X, Liu C, Zhang Y, Cui H, Wang S, Gao Y, Wang X.   +10 more
europepmc   +1 more source

Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability

Advanced Science, EarlyView.
Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang, Tsz Kwan Yau, Joyce Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan   +6 more
wiley   +1 more source

Single‐cell transcriptomics reveals IRF7 regulation of the tumor microenvironment in isocitrate dehydrogenase wild‐type glioma

MedComm
Mutations in isocitrate dehydrogenase (IDH) are important markers of glioma prognosis. However, few studies have examined the gene expression regulatory network (GRN) in IDH‐mutant and wild‐type gliomas.
Jinwei Li, Shengrong Long, Zhang Yang, Wei Wei, Shuangqi Yu, Quan Liu, Xuhui Hui, Xiang Li, Yinyan Wang   +8 more
doaj   +1 more source

Blood Cell‐Camouflaged Liquid Metal Nanoconjugates Orchestrate Treg Depletion and STING‐Amplified Photothermal Immunity for Metastatic Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Whole‐blood biomimetic engineering transforms liquid metal nanoparticles into a tripartite immunotherapeutic platform that orchestrates regulatory T‐cell depletion, photothermal‐induced immunogenic cell death, and activation of the stimulator of interferon genes pathway.
Nina Sang, Eijiro Miyako
wiley   +1 more source

Investigation of interferon regulatory factor, interferon alpha and beta levels in patients with Familial Mediterranean Fever

, 2023
Tıp Fakültesi, İç Hastalıkları Ana Bilim DalıAilevi Akdeniz Ateşi (AAA, Familial Mediterraean Fever; FMF) periyodik ateş ve serozal inflamasyon ile karakterize ataklarla kendini gösteren otoinflamatuar bir hastalıktır.
Kelici, Melike Yerliyurt
core   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Molecular cloning and characterization of crucian carp (Carassius auratus L.) interferon regulatory factor 7

, 2003
Interferon (IFN) can induce an antiviral state via interferon-regulatory transcription factors (IRFs), which bind to and control genes directed by the interferon-stimulated response element (ISRE).
Cheng-yu Hu, Yi-bing Zhang, Guo-ping Huang, Li-hua Wei, Qi-ya Zhang, Jing Zhang, Gui, JF, Chinese Acad Sci, Inst Hydrobiol, Dept Fish Genet & Breeding, Wuhan 430072, Hubei Province, Peoples R China, Jian-fang Gui   +7 more
core  

Expression regulation of zebrafish interferon regulatory factor 9 by promoter analysis

, 2013
We previously showed that a fish interferon (IFN) regulatory factor 9 (IRF9) homologue, crucian carp Carassius auratus IRF9, displays constitutively nuclear localization and involvement in fish IFN-dependent JAK-STAT signaling; however, little is known ...
Zhang, Yi-Bing, Zhang, Jian-She, Shi, Jun, Gui, Jian-Fang, Zhang, YB (reprint author), Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China.   +4 more
core   +1 more source

The CXCL5/CXCR2 Axis Attenuates Ferroptosis in Intrahepatic Cholangiocarcinoma Through the Positive Feedback Loop Between PTGS2 Transcriptional Activation and Neutrophil Recruitment

Advanced Science, EarlyView.
The CXCL5/CXCR2 axis directly inhibits ferroptosis in ICC cells by activating the NF‐κB/PTGS2 pathway. Meanwhile, the CXCL5/CXCR2 axis recruits N2 TANs, and the activated PTGS2 promotes the secretion of TNF‐α from the recruited N2 TANs via the CCL2/CCL7/CCR2 pathway, thereby activating the NF‐κB/PTGS2 axis and forming a positive feedback loop, which ...
Chanqi Ye, Kefeng Lin, Shuyao Yang, Yan Zhang, Wenli Gao, Jiaqi Chen, Ying Dong, Rui Bai, Yang Tian, Minghao Wang, Zhijun Yuan, Yuxiao Ma, Yuqin He, Ruyin Chen, Wenguang Fu, Qi Jiang, Qiong Li, Jian Ruan   +17 more
wiley   +1 more source

Targeting IRF7 to overcome gemcitabine resistance in pancreatic ductal adenocarcinoma

iScience
Summary: Interferon regulatory factor 7 (IRF7), a central transcription factor in interferon signaling, contributes to gemcitabine (GEM) resistance in pancreatic ductal adenocarcinoma (PDAC). We investigated how IRF7 mediates this resistance and explored
Gang-Hua Yang, Hao-Qi Yan, Zheng-Yang Lu, Qin-Hong Xu, Zheng Wang, Shuo Zhao   +5 more
doaj   +1 more source