Results 71 to 80 of about 24,207 (226)

MicroRNA-31 mediated by interferon regulatory factor 7 signaling facilitates control of Mycobacterium tuberculosis infection

International Journal of Medical Microbiology, 2022
Tuberculosis (TB) induced by Mycobacterium tuberculosis (M. tuberculosis) infection remains a global most deadly infectious disease. While development of more effective TB vaccines and therapeutics relies on identifications of true biomarkers designating
Zhiyi Zhang, Qiongdan Mai, Lijia Yang, Yiwei Chen, Zixu Chen, Tao Lin, Shimin Tan, Zhiying Wu, Yongjie Cai, Taimei Cui, Beiyin Ouyang, Yi Yang, Lingchan Zeng, Zhenhuang Ge, Sien Zhang, Gucheng Zeng, Jiang Pi, Lingming Chen   +17 more
doaj   +1 more source

SpaCut: Transcript‐Aware Morphology Fusion for Robust Cell Segmentation in Subcellular Spatial Transcriptomics

Advanced Science, EarlyView.
Subcellular spatial transcriptomics enables high‐resolution mapping of gene expression within tissues, but accurate cell segmentation is essential for assigning transcripts to individual cells. We present SpaCut, a deep learning framework that integrates transcriptomic features with nucleus‐guided morphological information to precisely delineate cell ...
Yongheng Li, Fangfang Zhu, Wenwen Min
wiley   +1 more source

Expression of Irf3 and Irf7 in tumour cells drives pancreatic cancer development and progression

, 2023
Background: The interferon regulatory factors 3 and 7 (Irf3 and Irf7) are transcription factors downstream of the Toll-like receptor 3 (Tlr3) signalling pathway.
Beyer, Georg, Kleeff, Jörg, Steiger, Katja, Straub, Tobias, Imhof, Axel, Mayerle, Julia, Mahajan, Ujjwal M, Regel, Ivonne, Benitz, Simone, Lisiecki, Hannah, Schotta, Gunnar, Fahr, Lisa, Mutter, Jurik, Michalski, Christoph W, Terrasi, Andrea, Lauber, Kirsten   +15 more
core   +1 more source

Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors.

PLoS ONE, 2010
Ro52 is a member of the TRIM family of single-protein E3 ligases and is also a target for autoantibody production in systemic lupus erythematosus and Sjögren's syndrome.
Rowan Higgs, Elisa Lazzari, Claire Wynne, Joan Ní Gabhann, Alexander Espinosa, Marie Wahren-Herlenius, Caroline A Jefferies   +6 more
doaj   +1 more source

Integrated Multiomic Analysis Reveals an EBV‐Associated MIF–SPP1+ Macrophage Axis Linking Tumor Stemness and Immune Dysfunction in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
This study maps how Epstein–Barr virus reshapes the cellular ecosystem of nasopharyngeal carcinoma. It identifies SPP1+ macrophages as partners of stemness‐associated tumor cells and dysfunctional T cells, links tumor‐derived MIF to macrophage recruitment and programming, and shows that macrophage‐derived SPP1 promotes tumorsphere formation and impairs
Guo‐Ying Liu, Shu‐Hui Lv, Shui‐Qing He, Yao‐Fei Jiang, Xing‐Si Peng, Jian‐Cong Sun, Fen He, Hai‐Yan Qin, Nian Lu, Wei‐Xin Bei, Lin‐Yu Zhao, Wan‐Qin Shen, Ze‐Yu Zhao, Lin Wang, Yan‐Qun Xiang, Wang‐Zhong Li   +15 more
wiley   +1 more source

A Bi‐Adjuvant Senolytic Nanovaccine Modulating Dendritic Cell Senescence Ameliorates Aging‐Related Metabolic Dysfunction

Advanced Science, EarlyView.
An active biomaterial‐based bi‐adjuvant nanovaccine restores the immunocompetence of aged dendritic cells to overcome senescent cell tolerance. Accompanied by the downregulation of mitotic kinases Aurka/b and attenuation of senescence‐associated PI3K/AKT phosphorylation, the nanovaccine enhances antigen‐presenting capacity and promotes potent cytotoxic
Qingxu Song, Xiaoxue Du, Wenbo Dong, Ying Wang, Xiaojing Wang, Qiliang Yin   +5 more
wiley   +1 more source

Regulation of the Transcriptional Activity of the IRF7 Promoter by a Pathway Independent of Interferon Signaling [PDF]

, 2005
Genes containing an interferon (IFN)-stimulated response element (ISRE) can be divided into two groups according to their inducibility by IFN and virus infection: one induced only by IFN and the other induced by both IFN and virus infection.
Ning, Shunbin, Huye, Leslie E., Pagano, Joseph S.   +2 more
core   +1 more source

Suppressed activation of the IRF7 and TLR9 by JAK2V617F gold nanoparticles

Immunogenetics
Abstract Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-MPNs) are characterized by the overproduction of myeloid cells and a lack of response to cytokine signaling, along with genomic instability and the accumulation of nucleic acids in the cytoplasm.
Berkay Tokcan, Esra Nur Demirtaş, Selçuk Sözer   +2 more
openaire   +2 more sources

siRNAs to Knockdown Antiviral Chemokine-related Genes in FRhK-4 Cells

Journal of Food Protection, 2023
The objective of this study was to generate small interfering RNA (siRNA) to knockdown antiviral chemokine-related genes in fetal rhesus monkey kidney (FRhK-4) cells.
Eunyoung Park, Yoonjeong Yoo, Sangeun Park, Changsun Choi, Yohan Yoon   +4 more
doaj   +1 more source

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source