Results 91 to 100 of about 24,207 (226)

Vaginal host–microbe signatures linked to placental outcomes in mares

Equine Veterinary Journal, EarlyView.
Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule, Babiche Heil, Jamie K. Norris, Kristene Gedye, Xiaoxiao Lin, Ward De Spiegelaere, Peter Daels, Pouya Dini   +7 more
wiley   +1 more source

SMAD3 and IRF7 siRNA reduce target transcript expression in ΔSTING, ΔIFNAR and ΔIRF7 cell lines.

, 2021
tHF, ΔSTING (A-B), ΔIFNAR (C-D) or ΔIRF7 (E-F) cell lines were transfected with negative control, miR-UL22A mimic or SMAD3 or IRF7 siRNA for 48 hours after which cells were additionally mock transfected or transfected with ISD90 for 16 hours.
Andrew H. Pham (11302575), Jennifer Mitchell (243882), Sara Botto (210516), Kara M. Pryke (11302578), Meaghan H. Hancock (3338148), Victor R. DeFilippis (8496240)   +5 more
core   +1 more source

Interferon regulatory factor-7 modulates experimental autoimmune encephalomyelitis in mice

Journal of Neuroinflammation, 2011
Background Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) with unknown etiology. Interferon-β (IFN-β), a member of the type I IFN family, is used as a therapeutic for MS and the IFN signaling pathway is implicated ...
Salem Mohammad, Mony Jyothi T, Løbner Morten, Khorooshi Reza, Owens Trevor   +4 more
doaj   +1 more source

Impact of Single‐Cell RNA Reference Selection for the Deconvolution of Breast Cancer Spatial Transcriptomics Datasets

International Journal of Cancer, EarlyView.
ABSTRACT Spot‐based spatial transcriptomics (ST) allows for unbiased gene expression analysis within tissue architecture, overcoming the limitations of single‐cell RNA sequencing (scRNA‐seq) by preserving spatial context. However, the high spatial resolution in ST leads to cellular heterogeneity within spots, requiring computational deconvolution to ...
Stefan Altendorfer, Scott J. Walker, Carsten O. Daub   +2 more
wiley   +1 more source

The VAD domain of bat IRF7 is functionally conserved with that of human IRF7.

, 2014
A. The full length human and bat IRF7 functional domain and a truncation mutant of bat IRF7 (Δ225–331, bat_tIRF7) are illustrated schematically. (B) Deletion of the VAD domain of bat IRF7 abolishes IFN transactivation.
Lijun Wu (152858), Ashley Mansell (80778), Zhengli Shi (203756), Michelle L. Baker (106512), Peng Zhou (116747), Paul Monaghan (270866), Lin-Fa Wang (145863), Chris Cowled (203755), Diane Green (369622)   +8 more
core   +1 more source

Interferon Regulatory Factor 5 Represses Expression of the Epstein-Barr Virus Oncoprotein LMP1: Braking of the IRF7/LMP1 Regulatory Circuit [PDF]

, 2005
We have reported evidence for a positive regulatory circuit between interferon regulatory factor 7 (IRF7) and the Epstein-Barr virus (EBV) oncoprotein 1 (LMP1) (S. Ning, A. M. Hahn, and J. S. Pagano, J. Virol. 77:9359-9368, 2003).
Huye, L. E., Ning, S., Pagano, J. S.
core   +1 more source

IRF7 orchestrates proinflammatory macrophage polarization and joint destruction in rheumatoid arthritis

Arthritis Research & Therapy
Objectives Rheumatoid arthritis (RA) involves synovial inflammation driven by pathogenic macrophages, whose polarization is regulated by transcription factors (TFs).
Huatao Liu, Changhua Wu, Guojian Li, Xiaoshuai Peng, Zhaoqiang Zhang, Zepeng Su, Jiajie Lin, Xinglang Wang, Huiyong Shen, Yanfeng Wu, Wenjie Liu, Peng Wang, Guan Zheng   +12 more
doaj   +1 more source

Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Research Progress and Precision Diagnosis‐Therapy Under the Integrated Neuro–Immune–Metabolic–Microbiota Axis Framework

iMetaMed, EarlyView.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is increasingly recognized as a systemic disorder rather than a purely local prostate disease. The diagram illustrates the transition from the traditional local prostate‐centered model to a multi‐axis systemic framework involving clinical heterogeneity, local prostatic inflammation, systemic ...
Kun Wang, Jinfei Liu, Qiangsheng Wang, Lei Fan, Ziang Li, Xuexin Yu, Yonghao Chen, Xiaofan Lu, Guiyi Liao, Jialin Meng, Yu Guan   +10 more
wiley   +1 more source

Characterization of IRF7 expression in the overexpression cell line.

, 2015
(A) Two different primer sets, specific to each endogenous or vector driven gene, were designed in the downstream region of the IRF7 CDS to differentiate between native versus construct driven expression.
Tae Hyun Kim (91783), Huaijun Zhou (244952)   +1 more
core   +1 more source

Intersection of systemic lupus erythematosus and autoimmune thyroid disease: Shared pathophysiology, epidemiology, diagnosis, and management

Rheumatology &Autoimmunity, EarlyView.
A proposed mechanistic framework of systemic lupus erythematosus (SLE) and autoimmune thyroid disease (AITD) pathogenesis. In Stage 1, genetically susceptible individuals harbor risk variants within major histocompatibility complex (HLA) and non‐HLA loci that impair central and peripheral immune tolerance mechanisms within the thymic and peripheral ...
Elisa Elisa, Awalia Awalia, Deasy Ardiany, Henry Sutanto   +3 more
wiley   +1 more source