Results 111 to 120 of about 24,207 (226)
IRF7 binds to the an IRF7-RE located in the FXR promoter.
, 2013 (A) Electrophoretic Mobility shift assay (EMSA). Nuclear extracts from Raw264.7 cells left untreated or stimulated with CpG were incubated in the presence of a wild type or a mutated IRF7 biotin-labeled probe.
Barbara Renga (134135) +9 more
core +1 more source
eLife, 2018 Type I interferon (IFN-I) responses are critical for the control of RNA virus infections, however, many viruses, including Dengue (DENV) and Chikungunya (CHIKV) virus, do not directly activate plasmacytoid dendritic cells (pDCs), robust IFN-I producing ...
Brian Webster +12 more
doaj +1 more source
Spatial Transcriptomics Identifies Characteristic Immunological Niches in Atopic Dermatitis
Allergy, EarlyView.Spatially organized immune niches containing mature migratory dendritic cells (mmDCs) and CD4+ T cells in atopic dermatitis lesions support localized T cell activation and may contribute to disease persistence. Spatial transcriptomics identifies conserved immune niches in atopic dermatitis lesions, characterized by close co‐localization of CD4+ T cells
Lina Gross +11 more
wiley +1 more source
Understanding extracellular vesicles in antiaging
Periodontology 2000, EarlyView.Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad +3 more
wiley +1 more source
Meq inhibits the phosphorylation and nuclear translocation of IRF7.
, 2019 (A) DF-1 cells were left untreated or transfected with the empty vector or Meq-Flag plasmid and treated with IFN stimulatory DNA (ISD) for 12 h. Cell lysates were left untreated or treated with calf intestine alkaline phosphatase (CIP) for 1 h, and ...
Zengkun Xu (7411436) +14 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Downregulation of mitotically associated long non‐coding RNA (MANCR) disturbs transcriptome and proteome in endothelial cells, possibly leading to endothelial and vascular dysfunction in preeclampsia. Abstract Preeclampsia (PE) is a hypertensive disorder during pregnancy, which is characterized by a wide spectrum of endothelial ...
Si‐Yan Zhang, Chi Zhou, Jing Zheng
wiley +1 more source
Veterinary ResearchBats are natural hosts for various highly pathogenic viruses, which pose a considerable threat to humans and animals. However, they rarely display signs of disease infection from these viruses. The expression of IRF7-induced IFN-β plays a crucial role in
Jie Wang +11 more
doaj +1 more source
Advanced Oncology, Volume 1, Issue 1, December 2026.Messenger RNA constructs encoding nontumor antigens are proposed to sensitize cold tumors to checkpoint blockade. Observational survival estimates favor vaccination but are heterogeneous, and bias‐focused analyses find no significant difference once time‐zero is aligned. Epitope spreading remains undemonstrated in humans. This review separates what the
Sarfaraz K. Niazi
wiley +1 more source
A genetic screen to identify deubiquitinases as regulators of IRF7
Abstract Virus infection rapidly induces the production and secretion of interferons (IFNs), amplifying antiviral responses in infected and neighboring uninfected cells. IFN regulatory factor 7 (IRF7), the ‘master transcription factor,’ is pivotal in IFN induction, particularly in myeloid cells.
Shumin Fan +5 more
openaire +1 more source
Computational and Systems Oncology, Volume 6, Issue 1, December 2026.ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and HER2 expression. This lack of receptors limits targeted therapies and contributes to high rates of recurrence.
Md Naiyem Islam +3 more
wiley +1 more source