Results 121 to 130 of about 24,207 (226)

MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions

Immunology, Volume 179, Issue 4, Page 537-553, December 2026.
MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula, Saurabh Mishra, Pugazhendhi Kannan, Annette Bellar, Amy Attaway, Nicole Welch, Srinivasan Dasarathy   +6 more
wiley   +1 more source

A conserved IRF7 responsive element is expressed in the promoter of FXR.

, 2013
(A) Analysis of the FXR promoter was performed with the on-line software TFsearch. The human FXR 5'flanking region contains an IRF7-RE at −602 base pairs with respect to the transcriptional start site ATG.
Barbara Renga (134135), Angela Zampella (186821), Stefano Fiorucci (134151), Andrea Mencarelli (134128), Sabrina Cipriani (134132), Claudio D'Amore (134144), Angela Bruno (134140), Daniela Francisci (167519), Eleonora Distrutti (134147), Adriana Carino (277117)   +9 more
core   +1 more source

P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus.

PLoS Pathogens, 2019
Interferon-inducible p200 family protein IFI204 was reported to be involved in DNA sensing, and subsequently induces the production of type I interferons and proinflammatory mediators.
Liu Cao, Yanxi Ji, Lanyi Zeng, Qianyun Liu, Zhen Zhang, Shuting Guo, Xiaolong Guo, Yongjia Tong, Xiaolu Zhao, Chun-Mei Li, Yu Chen, Deyin Guo   +11 more
doaj   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, Volume 13, Issue 62, 9 November 2026.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, Volume 13, Issue 62, 9 November 2026.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

IRF7 is a novel prognostic biomarker in kidney renal clear cell carcinoma

Scientific Reports
Interferon regulatory factor 7 (IRF7) regulates immune responses but its prognostic role in kidney renal clear cell carcinoma (KIRC) is undefined. Given KIRC’s high incidence (70–80% of renal cancers) and limited late-stage therapies, we assessed IRF7’s ...
Shuangshuang Fu, Wenhui Zhou, Wei Yin, Ying Chen, Liyuan Cao, Yusa Chen, Zheng Xiao   +6 more
doaj   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, Volume 4, Issue 4, Page 419-434, November 2026.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

Association of a functional IRF7 variant with systemic lupus erythematosus

, 2010
OBJECTIVE: Previous genome wide association study conducted in a population of European ancestry identified rs4963128, a KIAA1542 SNP 23kb telomeric to IRF7, in strong association with SLE.
Harley, JB, Shen, N, Grossman, JM, Arnett, FC, Zhao, J, Howe, HS, Guthridge, JM, Tsao, BP, Kaufman, KM, Mok, MY, Song, YW, Qian, XX, Bae, SC, Wang, J, Hahn, BH, Yu, Y, Fu, Q   +16 more
core   +1 more source

Lacticaseibacillus rhamnosus SC07 Alleviates Liver Oxidative Damage Association With PPAR Signaling and Immunometabolic Reprogramming in Female Mice With Lipid Disorders

Food Science &Nutrition, Volume 14, Issue 11, November 2026.
Lacticaseibacillus rhamnosus SC07 alleviates lipid‐driven liver oxidative damage by activating PPAR signaling to reprogram lipid metabolism and remodel immunocyte populations, thereby enhancing antioxidant defenses and restoring liver function. ABSTRACT Liver oxidative damage, often stemming from lipid metabolic dysregulation, represents a critical ...
Linxiu Wu, Tiantian Li, Shumin Ye, Peng Chen, Rongkang Hu   +4 more
wiley   +1 more source

Genotype frequencies of predicted amino acid substitutions in Sooty Mangabey IRF7.

, 2013
aaa position in SM IRF7.
Steven E. Bosinger (451757), Zachary P. Johnson (451758), Mirko Paiardini (243070), Thomas H. Vanderford (220607), Rongtuan Lin (159368), Perla M. del Rio Estrada (451763), Nirav Patel (451760), Kathryn A. Folkner (451759), John Hiscott (159374), Guido Silvestri (94156), Simon P. Jochems (451762), Tayebeh Hashempour (451761)   +11 more
core   +1 more source