Results 141 to 150 of about 24,207 (226)

Cellular Senescence Dysregulates Antiviral Interferon Responses in Idiopathic Pulmonary Fibrosis

Aging Cell, Volume 25, Issue 11, November 2026.
Senescent idiopathic pulmonary fibroblasts (IPF) lung fibroblasts are transcriptomically uncoupled from a functional response to virus relative to healthy (HLF) lung fibroblasts. HLF lung fibroblasts require viral effectors STAT1 or IRF3 to enact a viral response while IPF lung fibroblasts do not rely on these axes in response to virus.
Jun‐Wei B. Hughes, Yasmina Reisser, Franziska Hornung, Tyler A. U. Hilsabeck, Fiona Senchyna, Ana L. Coelho, Tsung‐Che Ho, Kevin Schneider, David Furman, Cory M. Hogaboam, Claude Jourdan Le Saux, Pierre‐Yves Desprez, Stefanie Deinhardt‐Emmer   +12 more
wiley   +1 more source

Repositioning Non‐Ablative Fractional Lasers ‐ Molecular and Histological Insights from a scoping review

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 11, Page 1548-1558, November 2026.
Summary Near‐infrared non‐ablative fractional lasers (NAFL) are established for skin rejuvenation and scar treatment and have attracted interest for their expanding therapeutic potential. This scoping review aims to revisit and reposition NAFL within a fluence‐dependent continuum of tissue modulation, based on evidence from 27 studies of lasers ...
Guy Erlich, Uwe Paasch, Kevin Jacobsen, Merete Haedersdal, Uffe Høgh Olesen   +4 more
wiley   +1 more source

Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

, 2012
Breast cancer metastasis is a key determinant of long-term patient survival. By comparing the transcriptomes of primary and metastatic tumor cells in a mouse model of spontaneous bone metastasis, we found that a substantial number of genes suppressed in ...
Slaney, Clare Y., Gould, Jodee, Hertzog, Paul, Samarajiwa, Shamith, De Weerd, Nicole, Clare Y Slaney, Anderson, Robin, Withana, Nimali, Nicole A de Weerd, Smyth, Mark John, Sam Forster, Bradley N Bidwell, Andrews, Daniel, Argani, Pedram, Parker, Belinda S., Anderson, Robin L., Mangan, Niamh, Nimali P Withana, Mark J Smyth, Robin L Anderson, Jodee Gould, Paul J Hertzog, Niamh E Mangan, Mangan, Niamh E., Pedram Argani, Cao, Yuan, Yuan Cao, Shamith A Samarajiwa, Parker, Belinda, Forster, Sam, Mikeska, Thomas, Thomas Mikeska, Hertzog, Paul J., Bidwell, Bradley, Sherene Loi, Andreas Möller, Samarajiwa, Shamith A., Müller, Andreas, Loi, Sherene, Withana, Nimali P., Daniel Andrews, Smyth, Mark J., Belinda S Parker, Slaney, Clare, Bidwell, Bradley N., De Weerd, Nicole A.   +45 more
core   +1 more source

Deficiency of Tlr7 and Irf7 in mice increases the severity of COVID-19 through the reduced interferon production

Communications Biology
Toll-like receptor 7 (Tlr7) deficiency-accelerated severe COVID-19 is associated with reduced production of interferons (IFNs). However, the underlying mechanisms remain elusive.
Chenxiao Wang, Mst Shamima Khatun, Calder R. Ellsworth, Zheng Chen, Mohammad Islamuddin, Ana Karina Nisperuza Vidal, Mohammad Afaque Alam, Shumei Liu, Janet E. Mccombs, Nicholas J. Maness, Robert V. Blair, Jay K. Kolls, Xuebin Qin   +12 more
doaj   +1 more source

Repositionierung nicht‐ablativ fraktionierter Laser – Scoping Review molekularer und histologischer Effekte

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 11, Page 1548-1559, November 2026.
Zusammenfassung Nicht‐ablative fraktionierte Laser (NAFL), die im nahen Infrarotlicht emittieren, sind zur Hautverjüngung sowie Narbenbehandlung etabliert und wegen neuer therapeutischer Potentiale interessant. Dieser Scoping‐Review bildet die Grundlage, NAFL anhand eines fluenzabhängigen Kontinuums der Gewebemodulation anhand von 27 relevanten Studien
Guy Erlich, Uwe Paasch, Kevin Jacobsen, Merete Haedersdal, Uffe Høgh Olesen   +4 more
wiley   +1 more source

IRF7 Gene [PDF]

, 2020
openaire   +1 more source

Bank1 deficiency reduces the nuclear translocation of IRF7.

, 2016
Levels of IRF7 protein in the (A) cytosol and the (B) nucleus following TLR7 agonist stimulation for the indicated times was detected by immunoblot on purified splenic B cells.
Marta E. Alarcón-Riquelme (192882), Ying-Yu Wu (394718), Ryuji Iida (452407), Ramesh Kumar (244395), Harini Bagavant (3168090)   +4 more
core   +1 more source

Interferon regulatory factor 7 alleviates the experimental colitis through enhancing IL-28A-mediated intestinal epithelial integrity

Journal of Translational Medicine
Background The incidence of inflammatory bowel disease (IBD) is on the rise in developing countries, and investigating the underlying mechanisms of IBD is essential for the development of targeted therapeutic interventions. Interferon regulatory factor 7
Furong Qing, Hongbo Tian, Biyao Wang, Bingyu Xie, Lina Sui, Xiaoyan Xie, Wenji He, Tiansheng He, Yumei Li, Liangmei He, Qin Guo, Zhiping Liu   +11 more
doaj   +1 more source

IRF7 wt Allele [PDF]

, 2020
openaire   +1 more source

IRF7 controls spontaneous autoimmune germinal center and plasma cell checkpoints

Journal of Experimental Medicine
How IRF7 promotes autoimmune B cell responses and systemic autoimmunity is unclear. Analysis of spontaneous SLE-prone mice deficient in IRF7 uncovered the IRF7 role in regulating autoimmune germinal center (GC), plasma cell (PC), and autoantibody responses and disease.
Adam J. Fike, Kristen N. Bricker, Michael V. Gonzalez, Anju Maharjan, Tien Bui, Keomonyroth Nuon, Scott M. Emrich, Julia L. Weber, Sara A. Luckenbill, Nicholas M. Choi, Renan Sauteraud, Dajiang J. Liu, Nancy J. Olsen, Roberto Caricchio, Mohamed Trebak, Sathi Babu Chodisetti, Ziaur S.M. Rahman   +16 more
openaire   +3 more sources