Results 131 to 140 of about 24,207 (226)

Glial Dysfunction and Memory Impairments in a Model of Pediatric Obstructive Sleep Apnea

Glia, Volume 74, Issue 11, November 2026.
Generation and analysis of an snRNA‐seq atlas of the hippocampus in POSA. Validation of reduced protein expression of six genes across four cell types. Cellular‐level investigation of aberrant glial function in POSA using transgenic reporter mice. ABSTRACT Pediatric obstructive sleep apnea (POSA) is a common childhood disease that often causes aberrant
Michael R. Williamson, Jorge Botas, Mahyar J. Hedayatpour, Thea Zlatkov, Akdes Serin Harmanci, Christopher J. Yates, Kenneth Nobleza, Roshan Ailani, Adam C. Adler, Farrah Kheradmand, Hyun Kyoung Lee, Benjamin Deneen, Hyun‐Hwan Jeong, Arvind Chandrakantan   +13 more
wiley   +1 more source

IRF7 drives macrophages to kill bacteria and improves septic outcomes via autophagy

JCI Insight
Sepsis contributes substantially to mortality rates worldwide, yet clinical trials that have focused on its underlying pathogenesis have failed to demonstrate benefits.
Guiming Chen, Kangxin Li, Haihua Luo, Lianxu Zhao, Yong Jiang   +4 more
doaj   +1 more source

Dengue Virus Pathogenesis: Innate Immune Signaling and Cell Death Receptor Pathways

Immunity, Inflammation and Disease, Volume 14, Issue 11, November 2026.
ABSTRACT Background The infection caused by the dengue virus (DENV) involves a complicated interaction between viral replication and the body's immune responses. As the first line of defense, the innate immune response limits viral replication but can also lead to immunopathology if it is improperly regulated.
Farjana Islam
wiley   +1 more source

Novel ZNFX1 Variants Associated With Refractory Anemia and Interstitial Lung Disease

Molecular Genetics &Genomic Medicine, Volume 14, Issue 11, November 2026.
We identified three novel ZNFX1 variants in a child with refractory anemia and interstitial lung disease. Integrated transcriptomic, structural, and selected interferon‐stimulated gene expression analyses supported the molecular diagnosis and expanded the mutational and clinical spectrum of ZNFX1 deficiency, highlighting associated immune dysregulation.
Lu Jiang, Chan Huang, Xiaohan Hu, Xueqian Wang, Jiawei Chen, Canhong Zhu, Xiaozhong Li, Aiqing Zhang   +7 more
wiley   +1 more source

Fibroblast IRF7-mediated chondrocyte apoptosis affects the progression of collapse in steroid-induced osteonecrosis of the femoral head

Journal of Orthopaedic Surgery and Research
Purpose The objective of this study was to identify potential genes implicated in the “peri-collapse” synovium of osteonecrosis of the femoral head through coding gene sequencing and to further clarify their specific mechanisms via in vitro experiments ...
Han Longfei, Fang Weihua, Han Mingli, Zhuang Zhikun, He Mincong, Wei Qiushi   +5 more
doaj   +1 more source

Probiotics as a Strategy for Mitigating Viral Infections in Poultry: Immunomodulatory Mechanisms and Therapeutic Potential

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
Probiotics—particularly Lactobacillus acidophilus, L. casei and L. plantarum—may mitigate NDV, AIV and IBV infections by modulating immunity, supporting gut microbiome and barrier function, and enhancing vaccine responses, although stronger strain‐specific, safety, mechanistic and field‐based evidence is needed. ABSTRACT Poultry viral infections remain
Elmer Nayra Ametefe, Daniel Saka, Juliet Nuerkie Anang, Lourraine Sena Doh, Leonard Kofi Adjorlolo   +4 more
wiley   +1 more source

IRF7 orchestrates maladaptive smooth muscle cell phenotype switching in atherosclerosis

Precision Clinical Medicine
Abstract Background Smooth muscle cells (SMCs) exhibit remarkable plasticity, undergoing extensive phenotypic switching to generate a highly heterogeneous population within atherosclerotic plaques.
Cai, Rundong, Chen, Xin, Zhang, Hongxia, Wang, Qi, Xie, Wanrong, Pan, Xinghua, Liang, Chun, Zhu, Haiying   +7 more
openaire   +3 more sources

Stage-specific antiviral roles of IFIH1, IRF7, and MAVS in the interferon-mediated response to DHAV-3 infection

Poultry Science
Duck hepatitis A virus genotype 3 (DHAV-3) is the predominant causative agent of duck viral hepatitis in East Asia, yet its mechanisms of immune evasion remain unclear.
Huihui Li, Yi Tang, Shuisheng Hou, Suyun Liang   +3 more
doaj   +1 more source

Microbial Characteristics of Weissella cibaria HRL3 and Its Immunostimulatory Effects via TLR3/TLR9‐Dependent IFN‐α Production

Journal of Food Science, Volume 91, Issue 11, November 2026.
ABSTRACT Rhinacanthus nasutus (L.) Kurz is a medicinal plant whose roots, stems, and leaves are commonly used in tea and traditional Chinese medicine; however, the beneficial effects of its flowers remain to be investigated. In this study, the lactic acid bacteria (LAB) found in the flowers of R.
Fumie Niitsuma, Hiroka Sasahara, Akihiro Masaki, Ayaha Toritani, Minako Tsukamoto, Tomoya Takahashi, Sachi Tanaka   +6 more
wiley   +1 more source

IFN-β is induced in a dose-dependent manner by bat IRF7.

, 2014
(A) Sendai virus (SeV) induced higher IFN-β induction with an increasing dose of bat IRF7. Bat PaKiT03 cells (2×105 per well) were cotransfected with 0, 10, 50 or 100 ng pCAGGS-bat IRF7 (left to right, last three bars) and bat IFN-β promoter plasmid.
Lijun Wu (152858), Ashley Mansell (80778), Zhengli Shi (203756), Michelle L. Baker (106512), Peng Zhou (116747), Paul Monaghan (270866), Lin-Fa Wang (145863), Chris Cowled (203755), Diane Green (369622)   +8 more
core   +1 more source