Results 101 to 110 of about 24,207 (226)
Transcriptional induction of IRF7 and IRF9 in coronavirus infections.
, 2020 The host transcriptional response provides critical insights into host-pathogen interactions. We mined multiple independent published microarray datasets (1-5) and discovered transcriptional induction of the interferon regulatory factors IRF7 and IRF9 in vitro following infection of human cells with an isolate of the Middle East Respiratory Syndrome ...
openaire +2 more sources
, 2013 HeLa cells were stimulated with the indicated ligands for 4 and 18 hrs. Cell lysates were immunoprecipitated with an anti-Ro52 antibody and immunoblotted with an anti-IRF7 antibody, an anti-Ro52 antibody and an anti-α-actinin antibody.
Rowan Higgs (363081) +6 more
core +1 more source
Fish species-specific TRIM gene FTRCA1 negatively regulates interferon response through attenuating IRF7 transcription [PDF]
, 2019 In mammals and fish, emerging evidence highlights that TRIM family members play important roles in the interferon (IFN) antiviral immune response. Fish TRIM family has undergone an unprecedented expansion leading to generation of finTRIM subfamily, which
Wu, Min +3 more
core +1 more source
YTHDF2 in hepatocellular carcinoma: Bridging m6A modification and cancer progression
VIEW, EarlyView.Abstract YTH N6‐methyladenosine RNAbinding protein F2 (YTHDF2) is an N6‐methyladenosine (m6A) reader protein that mainly regulates the stability of methylated transcripts through mRNA decay. In the liver, YTHDF2 is involved in metabolic homeostasis, oxidative stress responses, and immune regulation.
Sijie Zang +7 more
wiley +1 more source
Cardiovascular Plasticity and Adaptation of High‐Altitude Birds and Mammals
Integrative Zoology, EarlyView.This schematic depicts the cardiovascular adaptations of mammals and birds to high‐altitude hypoxia. It highlights key phenotypic changes in oxygen transport and cardiac responses, driven by molecular mechanisms including transcriptional regulation and genetic modifications.
Huishang She, Yanhua Qu
wiley +1 more source
Decreasing IRF7 expression enhances HIV-1 and RelA transcription.
, 2015 (A) IRF7, (C and F) HIV-1, (B, D and G) IFNα and (E and H) RelA transcription in HIV-1-infected cervical tissues treated with random and IRF7 targeting siRNA were quantified by RT-PCR before (A) and (B) and on days 1 (C, D and E) and 3 (F, G and H) after
Sherrill L. Macura (762319) +5 more
core +1 more source
Allergy, EarlyView.Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri +11 more
wiley +1 more source
Allergy, EarlyView.This study described the development of an experimental model for eosinophilic gastritis (EoG). Experimental EoG recapitulates histopathological features of human disease. including foveolar elongation, fibrosis, eosinophilia, mastocytosis and shared transcriptional programs.
Anish Dsilva +7 more
wiley +1 more source
Transactivation of IFNA4 promoter and nuclear localization by Sooty Mangabey IRF7.
, 2013 (A) HEK293 cells were transfected with the luciferase reporter plasmid containing the human IFNA4 promoter, TBK1 and IRF7 constructs from human, rhesus, and sooty mangabeys, or vehicle, as indicated.
Steven E. Bosinger (451757) +11 more
core +1 more source
Dendritic Cell α‐Ketoglutarate Regulates Tfh Polarization in Allergy
Allergy, EarlyView.Allergen induces a dendritic cell metabolism shift toward glutaminolysis with α‐ketoglutarate as a regulator of Tfh subset polarization. Glutaminolysis is required for DC allergen uptake, co‐stimulatory molecule expression, and CLR expression. Modulation of glutaminolysis, JmjD3 histone demethylation, or HIF‐1α degradation alters Tfh polarization and ...
Anuj Tharakan +16 more
wiley +1 more source